Current Directions in Biomedical Engineering

Open Access Published by De Gruyter

Volume 1 Issue 1

Issue of Current Directions in Biomedical Engineering

Contents
Journal Overview

Research Article

Open Access September 12, 2015

Development and characterization of superparamagnetic coatings

I. Kuschnerus, K. Lüdtke-Buzug

Page range: 1-4

Superparamagnetic iron oxides (SPIOs) are used as tracer for the new imaging technique Magnetic Particle Imaging. The stability of ferrofluids for medical application has a great importance, in addition to the particle size. The shell material, which protects the iron core prior from agglomeration and sedimentation, can be degraded by various processes. Another important aspect of stability is the constant performance of magnetisation. Therefore, the measurement of the magnetisation of the particles must be controlled in order to ensure the stability of the samples.

Research Article

Open Access September 12, 2015

Open Access September 12, 2015

A novel coaxial nozzle for in-process adjustment of electrospun scaffolds’ fiber diameter

Electrospun mats and their dependence on process parameters

A. Becker, H. Zernetsch, M. Mueller, B. Glasmacher

Page range: 104-107

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Abstract

Electrospinning is a versatile method of producing micro- and nanofibers deposited in mats used as scaffolds for tissue engineering. Depending on the application, single or coaxial electrospinning can be used. Coaxial electrospinning enables the use of a broad spectrum of materials, the fabrication of hollow or core/shell fibers and an automatisation of the entire electrospinning process. In this regard, the design of coaxial nozzles plays a major role in a standardized as well as tailor-made scaffold fabrication. For this purpose an optimised coaxial nozzle has been designed and fabricated. Furthermore, tests have been carried out to validate the new nozzle design. With the use of the costum-made nozzle polymer concentration could be varied in a gradual manner. The variation in polymer concentration lead to fiber diameters between 0.75 to 3.25 μm. In addition, an increase in rotating velocity lead to an increase in fiber alignment as well as a slight decrease in fiber diameter. The demonstrated modifications of coaxial electrospinning proved to be a powerful tool for in-process adjustments of scaffold fabrication.

Research Article

Open Access September 12, 2015

Open Access September 12, 2015

Open Access September 12, 2015

Open Access September 12, 2015

Measuring different oxygenation levels in a blood perfusion model simulating the human head using NIRS

Preliminary results of model evaluation measurements

K. Rackebrandt, H. Gehring

Page range: 371-375

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Abstract

The oxygenation, perfusion and metabolism of the brain - segmented in both hemispheres - can be estimated from the oxygenation and hemoglobin levels of the venous blood in the cerebral efferent vessels. We present a phantom based model to simulate the anatomical target region which was connected to hemodynamic perfusion circuit to provide different oxygenation rates inside of the simulated target vessel (measurement cell) reproducible. A triple-wavelength (770, 808 and 850 nm) multi-distance NIRS sensor (6 photodiodes, linearly arranged, separated 6 mm each) was used to detect these different saturation levels. The results illustrate the capability to measure the optical property variation of hemoglobin due to oxygenation and deoxygenation processes in a specific vessel. Based on these first results a series of measurements is introduced to correlate the amount of reflected light to the actual oxygen saturation of the blood.

Research Article

Open Access September 12, 2015

Open Access September 12, 2015

Open Access September 12, 2015

Open Access September 12, 2015

Simulation of varying femoral attachment sites of medial patellofemoral ligament using a musculoskeletal multi-body model

Multi-body-model simulation of medial patellofemoral ligament attachment sites

A. Geier, T. Tischer, R. Bader

Page range: 547-551

Diagnostic Imaging
Biosignal Processing, Biomechanics, Image Processing, Modelling and Simulation
Information and Communication in Medicine, Telemedicine and e-Health
Surgery, Minimum Invasive Interventions, Endoscopy and Image Guided Therapy
Diagnostic and Therapeutic Instrumentation, Clinical Engineering
Micro- and Nanosystems in Medicine, Active Implants, Biosensors
Neuroengineering, Neural Systems, Rehabilitation and Prosthetics
Biomaterials, Cellular and Tissue Engineering, Artificial Organs
Biomedical Engineering for Audiology, Ophthalmology, Emergency and Dental Medicine

Article formats
Conference Proceedings Papers