This is an attempt to construct a strong numerical method for transportdiffusion equations with nonlinear reaction terms, which relies on the idea of the Modified Method of Characteristics that is explicit but stable and is second-order accurate in time. The method consists in convective-diffusive splitting of the equations along the characteristics. The convective stage of the splitting is straightforwardly treated by a quasi-monotone and conservative modified method of characteristics, while the diffusive-reactive stage can be approximated by an explicit scheme with an extended real stability interval. A numerical comparative study of the new method with Characteristics Crank-Nicholson and Classical Characteristics Runge-Kutta schemes, which are used in many transport-diffusion models, is carried out for several benchmark problems, whose solutions represent relevant transport-diffusion-reaction features. Experiments for transport-diffusion equations with linear and nonlinear reactive sources demonstrate the ability of our new algorithm to better maintain the shape of the solution in the presence of shocks and discontinuities.