Drug Metabolism and Personalized Therapy

Published by De Gruyter

Volume 6 Issue 3-4

Issue of Drug Metabolism and Personalized Therapy

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Contents
Journal Overview

December 1, 1988

Page range: I-IV

December 1, 1988

THE BIOCHEMISTRY OF ENDOGENOUS ORGANOSULPHUR COMPOUNDS

S.P. James,

Page range: 167-182

December 1, 1988

SULPHUR COMPOUNDS USED IN MEDICINE

M. Mitchard,

Page range: 183-202

December 1, 1988

SULPHOCONJUGATION AND SULPHOHYDROLYSIS

G.M. Powell,, G.F. White,, C.G. Curtis,, FA. Rose,

Page range: 203-218

December 1, 1988

SPECIES, ORGAN AND CELLULAR VARIATION IN THE FLAVIN-CONTAINING MONOOXYGENASE

E. Hodgson,, P.E. Levi,

Page range: 219-234

December 1, 1988

CYTOCHROME P-450 AND FAD-MONOOXYGENASE MEDIATED S- AND N-OXYGENATIONS

L.A. Damani,, A.A. Houdi,

Page range: 235-244

December 1, 1988

BIOLOGICAL CONSEQUENCES OF DRUG SULPHOXIDATION

S.C. Mitchell,

Page range: 245-252

December 1, 1988

PHARMACOGENETICS OF THE S-OXIDATION OF S-CARBOXYMETHYL-L-CYSTEINE

R.H. Waring,

Page range: 253-264

December 1, 1988

α -ΑΜΑΝΙΤΙΝ: A POSSIBLE SUICIDE SUBSTRATE-LIKE TOXIN INVOLVING THE SULPHOXIDE MOIETY OF THE BRIDGED CYCLOPEPTIDE

D. Michelot,, R. Labia,

Page range: 265-274

December 1, 1988

MECHANISM OF THE NEUROTOXIC AND HEPATOTOXIC EFFECTS OF CARBON DISULFIDE

R.R. Dalvi,

Page range: 275-284

December 1, 1988

STUDIES ON POSSIBLE SULFADIMETHOXINE TOXICITY TO LIVER AND LIVER DRUG METABOLIZING ENZYME SYSTEM OF GOATS, QUAIL AND RATS

R.R. Dalvi,, S.J. Trivedi,

Page range: 285-294

December 1, 1988

EFFECT OF SULPHYDRYL DRUGS ON PARACETAMOL-INDUCED HEPATOTOXICITY IN MICE

J.H.K. Yeung,

Page range: 295-302

December 1, 1988

INHIBITION OF RAT RENAL C-S LYASE: ASSESSMENT USING KIDNEY SLICE METHODOLOGY

I.S. Blagbrough,, B.W. Bycroft,, D.C. Evans,, P.N. Shaw,

Page range: 303-316

December 1, 1988

MECHANISM OF THIOAMIDE ANTITHYROID DRUG ASSOCIATED HYPOPROTHROMBINEMIA

J J. Lipsky,, M.O. Gallego,

Page range: 317-326

December 1, 1988

THIOLYTIC CLEAVAGE AND BINDING OF THE ANTITUMOUR AGENT CI-921 IN BLOOD

P. Kestell,, J.W. Paxton,, I.G.C. Robertson,, P.C. Evans,, RA. Dormer,, B.C. Baguley,

Page range: 327-336

December 1, 1988

S-OXYGENATION OF 7α-THIOMETHYLSPIRONOLACTONE BY THE FLAVIN-CONTAINING MONOOXYGENASE

John R. Cashman,, Sandra Pena,

Page range: 337-348

December 1, 1988

DNA-BINDING OF SULFUR-CONTAINING METABOLITES FROM 35S-iPENTACHLOROBUTADIENYL)-L-CYSTEINE IN BACTERIA AND ISOLATED RENAL TUBULAR CELLS

S. Vamvakas,, DA. Müller,, W. Dekant,, D. Henschler,

Page range: 349-358

December 1, 1988

THE EFFECT OF DIURNAL RHYTHMS ON THE HEPATOTOXICITY OF THIOACETAMIDE IN MALE AND FEMALE RATS

G.M. Lawrence,, A.C.H. Beesley,

Page range: 359-370

December 1, 1988

INVOLVEMENT OF GLUTATHIONE IN THE METABOLISM OF THE ANILINOACRIDINE ANTITUMOUR AGENTS CI-921 AND AMSACRINE

I.G.C. Robertson,, P. Kestell,, R.A. Dormer,, J.W. Paxton,

Page range: 371-382

December 1, 1988

THE EFFECT OF TWO SULPHUR-CONTAINING PESTICIDES, FENITROTHION AND ENDOSULFAN, ON GLUTATHIONE (GSH) CONTENT AND ON GSH S-TRANSFERASE AND γ-GLUTAMYL TRANSPEPTIDASE ACTIVITIES IN MIDGUT GLAND OF THE AMERICAN RED CRAYFISH PROCAMBARUS CLARKII

Amparo Blat,, Mar M. Almar,, Francisco J. Romero,

Page range: 383-394

December 1, 1988

THE TOXICITY OF DISULPHIDES TO ISOLATED HEPATOCYTES AND MITOCHONDRIA

S.D. Jatoe,, V. Lauriault,, L.G. McGirr,, Ρ J. O'Brien,

Page range: 395-412

December 1, 1988

MECHANISM OF INHIBITION OF HEPATIC BIOACTIVATION OF PARACETAMOL BY DIMETHYL SULFOXIDE

E.H. Jeffery,, K. Arndt,, W.M. Haschek,

Page range: 413-424

December 1, 1988

S-OXIDATION OF THIORIDAZINE TO PSYCHOACTIVE METABOLITES: AN ORAL DOSE-PROPORTIONALITY STUDY IN HEALTHY VOLUNTEERS

B.S. Chakraborty,, E.M. Hawes,, G. McKay,, J.W. Hubbard,, E.D. Korchinski,, K.K. Midha,, M.G. Choc,, W.T. Robinson,

Page range: 425-438

December 1, 1988

APPLICATION OF HIGH RESOLUTION H-NMR SPECTROSCOPY TO THE DETECTION OF PENICILLAMINE AND ITS METABOLITES IN HUMAN URINE

J.K. Nicholson,, J.A. Walshe,, I.D. Wilson,

Page range: 439-446

December 1, 1988

HPLC-ANALYSIS OF S-CARBOXYMETHYLCYSTEINE AND ITS SULPHOXIDE METABOLITES

J. Brockmöller,, Z.J. Simane,, I. Roots,

Page range: 447-456

December 1, 1988

About this journal

Objective

Drug Metabolism and Personalized Therapy (DMPT) is the official journal of the European Society of Pharmacogenomics and Personalised Therapy (ESPT). DMPT offers up-to-date research articles, reviews and opinion papers from the broad field of personalized therapy and pharmacogenomics. Specifically, it covers the following fields: pharmacogenetics, pharmacogenomics and drug metabolism research, dealing with established, new and potential drugs, herbal medicinal products, environmentally toxic chemicals, the mechanisms by which drugs and herbs can interact with each other and with biological systems, and the pharmacological and toxicological consequences of these interactions, as well as drug metabolism and excretion. More generally, it is concerned with the area of therapeutic individualization, particularly on the basis of pharmacogenetics, with regards to the use of pharmaceuticals and herbal medicine, including traditional medicine.
DMPT is an international scientific single-blind peer-review journal, which is issued quarterly with 8-10 articles per issue. The Journal publishes only English-language articles.

Please submit your manuscript here

Topics

drug metabolizing enzymes
pharmacogenetics and pharmacogenomics
biochemical pharmacology
molecular pathology
clinical pharmacology
pharmacokinetics and drug-drug interactions
immunopharmacology
neuropsychopharmacology
herbal medicine and traditional medicine

Article formats
Research Articles, Reviews and Mini Reviews, Opinion Papers, Short Communications, letters to the Editor, Case Reports, Editorials

Volume 6 Issue 3-4

Issue of Drug Metabolism and Personalized Therapy

TABLE OF CONTENTS

EDITORIAL

THE BIOCHEMISTRY OF ENDOGENOUS ORGANOSULPHUR COMPOUNDS

SULPHUR COMPOUNDS USED IN MEDICINE

SULPHOCONJUGATION AND SULPHOHYDROLYSIS

SPECIES, ORGAN AND CELLULAR VARIATION IN THE FLAVIN-CONTAINING MONOOXYGENASE

CYTOCHROME P-450 AND FAD-MONOOXYGENASE MEDIATED S- AND N-OXYGENATIONS

BIOLOGICAL CONSEQUENCES OF DRUG SULPHOXIDATION

PHARMACOGENETICS OF THE S-OXIDATION OF S-CARBOXYMETHYL-L-CYSTEINE

α -ΑΜΑΝΙΤΙΝ: A POSSIBLE SUICIDE SUBSTRATE-LIKE TOXIN INVOLVING THE SULPHOXIDE MOIETY OF THE BRIDGED CYCLOPEPTIDE

MECHANISM OF THE NEUROTOXIC AND HEPATOTOXIC EFFECTS OF CARBON DISULFIDE

STUDIES ON POSSIBLE SULFADIMETHOXINE TOXICITY TO LIVER AND LIVER DRUG METABOLIZING ENZYME SYSTEM OF GOATS, QUAIL AND RATS

EFFECT OF SULPHYDRYL DRUGS ON PARACETAMOL-INDUCED HEPATOTOXICITY IN MICE

INHIBITION OF RAT RENAL C-S LYASE: ASSESSMENT USING KIDNEY SLICE METHODOLOGY

MECHANISM OF THIOAMIDE ANTITHYROID DRUG ASSOCIATED HYPOPROTHROMBINEMIA

THIOLYTIC CLEAVAGE AND BINDING OF THE ANTITUMOUR AGENT CI-921 IN BLOOD

S-OXYGENATION OF 7α-THIOMETHYLSPIRONOLACTONE BY THE FLAVIN-CONTAINING MONOOXYGENASE

DNA-BINDING OF SULFUR-CONTAINING METABOLITES FROM 35S-iPENTACHLOROBUTADIENYL)-L-CYSTEINE IN BACTERIA AND ISOLATED RENAL TUBULAR CELLS

THE EFFECT OF DIURNAL RHYTHMS ON THE HEPATOTOXICITY OF THIOACETAMIDE IN MALE AND FEMALE RATS

INVOLVEMENT OF GLUTATHIONE IN THE METABOLISM OF THE ANILINOACRIDINE ANTITUMOUR AGENTS CI-921 AND AMSACRINE

THE EFFECT OF TWO SULPHUR-CONTAINING PESTICIDES, FENITROTHION AND ENDOSULFAN, ON GLUTATHIONE (GSH) CONTENT AND ON GSH S-TRANSFERASE AND γ-GLUTAMYL TRANSPEPTIDASE ACTIVITIES IN MIDGUT GLAND OF THE AMERICAN RED CRAYFISH PROCAMBARUS CLARKII

THE TOXICITY OF DISULPHIDES TO ISOLATED HEPATOCYTES AND MITOCHONDRIA

MECHANISM OF INHIBITION OF HEPATIC BIOACTIVATION OF PARACETAMOL BY DIMETHYL SULFOXIDE

S-OXIDATION OF THIORIDAZINE TO PSYCHOACTIVE METABOLITES: AN ORAL DOSE-PROPORTIONALITY STUDY IN HEALTHY VOLUNTEERS

APPLICATION OF HIGH RESOLUTION H-NMR SPECTROSCOPY TO THE DETECTION OF PENICILLAMINE AND ITS METABOLITES IN HUMAN URINE

HPLC-ANALYSIS OF S-CARBOXYMETHYLCYSTEINE AND ITS SULPHOXIDE METABOLITES

BOOK REVIEW