Open Access Published since January 1, 1994

Heterocyclic Communications

ISSN: 2191-0197

Editor-in-chief: Maged Henary

Impact Factor: 2.000

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Topical/Special Issues:

Special Issue: Undergraduate Research in the Synthesis of Biologically Active Small Molecules and Their Applications

Objective
Heterocyclic Communications (HC) is an open-access, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.

Topics

Development of novel synthetic methods
Significant improvement of known synthetic methods
Chemistry of natural products
Superior biological activity of novel heterocyclic compounds, rational design and synthesis of new drug candidates targeting specific biological receptors
Application of heterocyclic compounds as probes for biomolecules in biophysical and bioanalytical chemistry
Development of new substrates and catalysts in materials chemistry

Article formats
Preliminary Communications, Original Research Articles, Review Articles

Your Benefits

It is with a great deal of sadness to inform you of the death of one of our associate editors Professor Hidetoshi Yamada. We deeply thank for his support, work, and contribution to the journal.

Since 1st January 2019 Heterocyclic Communications has changed the publishing model to Open Access.

Articles accepted for publication in Heterocyclic Communications are subject to an Article Processing Charge of €1500

Your benefits:

Significant developments in heterocyclic chemistry
Synthetic routes to heterocyclic compounds with high biological activity
Imperative topics including theoretical analysis
Cutting-edge trends
Easy traceability through detailed experimental descriptions
Long-time preservation of the content (archiving) with Portico

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Heterocyclic Communication was previously published by Freund Publishing House Ltd.

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Volume 28 Issue 1

January 2022

Research Articles

Open Access February 11, 2022

Sono and nano: A perfect synergy for eco-compatible Biginelli reaction

Marzieh Tahmasbi, Nadiya Koukabi, Ozra Armandpour

Page range: 1-10

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Abstract

In this study, we evaluated the performance of nano-γ-Fe 2 O 3 –SO 3 H catalyst in the Biginelli reaction and synthesized 3,4-dihydropyrimidine-2-(1 H )-ones. This reaction was carried out under solvent-free and ultrasonic irradiation conditions and belonged to one-pot multicomponent reactions (MCRs) with an adopted aromatic aldehyde, ethyl acetoacetate, and urea as starting materials for the beginning of the reaction. The synthesized materials were efficient in synthesizing 3,4-dihydropyrimidine-2-(1 H )-ones via the Biginelli reaction under reaction conditions. Thus, the advantages of using nano-γ-Fe 2 O 3 –SO 3 H in the Biginelli reaction are short reaction time, high efficiency, green method, solvent free, and cost-effective. Furthermore, nano-γ-Fe 2 O 3 –SO 3 H as a heterogeneous catalyst can be recycled five times without significantly reducing catalytic activity. Graphical abstract

Open Access February 14, 2022

Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Soumaya Bellili, Nicholas J. Coltman, Nikolas J. Hodges, Fatma Allouche

Page range: 11-17

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Abstract

This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N -(5-cyano-3-methyl-1-phenyl-1 H -pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 precursors. The action of chlorosulfonyl isocyanate (CSI) with aminopyrazolo[3,4- d ]pyrimidines 2 was found to produce triazolopyrimidinones 5 . The MTT test that quantifies mitochondrial reductive function demonstrated that in both cell lines tested (PE/CA-PJ41 and HePG2 cells), the benzamide compounds 4 are moderately toxic with PE/CA-PJ41 cells and more sensitive than HePG2 cells.

Open Access February 15, 2022

“Click” assembly of novel dual inhibitors of AChE and MAO-B from pyridoxine derivatives for the treatment of Alzheimer’s disease

Zhao Jia, Huiyun Wen, Saipeng Huang, Yane Luo, Juanjuan Gao, Ruijie Wang, Kaikai Wan, Weiming Xue

Page range: 18-25

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Abstract

This study fast synthesizes numerous functionalized pyridoxines using click chemistry and assayed in vitro as inhibitors of the acetylcholinesterase (AChE), butyrylcholinesterase, and two monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the obtained compounds demonstrate good AChE and selective MAO-B inhibitory activities in the micromolar range, especially one compound, called 4k5 , exhibits excellent inhibitory performance against AChE (IC 50 = 0.0816 ± 0.075 μM) and MAO-B (IC 50 = 0.039 ± 0.003 μM). Finally, a docking study is carried out, demonstrating potential binding orientations and interactions of the compounds in terms of the AChE and MAO-B active sites.

Open Access March 19, 2022

Synthesis of 2,2-difluoro-2-arylethylamines as fluorinated analogs of octopamine and noradrenaline

Atsushi Tarui, Erika Kamata, Koji Ebisu, Yui Kawai, Ryota Araki, Takeshi Yabe, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote

Page range: 26-34

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Abstract

Abstrtact A series of 2,2-difluoro-2-arylethylamines was synthesized as fluorinated analogs of octopamine and noradrenaline with the expectation of bioisosteric OH/F exchanges. The syntheses of these compounds were performed by a Suzuki–Miyaura cross-coupling reaction of 4-(bromodifluoroacetyl)morpholine with aryl boronic acids to produce the intermediate 2,2-difluoro-2-arylacetamides, followed by transformation of difluoroacetamide to difluoroethylamine.

Open Access March 23, 2022

Cyclization of N-acetyl derivative: Novel synthesis – azoles and azines, antimicrobial activities, and computational studies

Eman O. Hamed, Mohamed G. Assy, Nabil H. Ouf, Doaa A. Elsayed, Magda H. Abdellattif

Page range: 35-43

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Abstract

2-Pyridone is considered as one of the most famous efficient pharmaceutical compounds. Many approaches were discovered to synthesize 2-pyridone. In this present research, chloroacetylation of benzylamine at simple conditions, EtONa/EtCOONa produced N -benzyl-2-chloroacetamide 2 . Compound 2 was allowed to react with different reagents. These reagents are acetylacetone, ethyl cyanoacetate, ethyl acetoacetate, and diethyl malonate, creating 2-pyridone derivatives with a good yield. The structures of the prepared compounds were elucidated by spectral data (IR, 1 HNMR, and 13 CNMR). The synthesized compound was tested for its antimicrobial activity against the Gram-positive ( Staphylococcus aureus ) and the Gram-negative ( Escherichia coli ) bacteria. In addition, the antifungal activities of the compounds were tested against two fungi ( Candida albicans and Aspergillus flavus ). Molecular docking studies were applied using the Autodock vina method. Theoretical methods prove all the experimental results by using molecular docking using Autodock vina and by ADEMT studies. The docking results represent that compound 20 had the best docking free energy, and it is the effective compound toward the selected bacterial and fungal proteins. ADME studies showed that the only compound 18 could cross the blood–brain barrier, and compound 15 was predicted to be soluble.

Open Access April 25, 2022

Two independent and consecutive Michael addition of 1,3-dimethylbarbituric acid to (2,6-diarylidene)cyclohexanone: Flying-bird-shaped 2D-polymeric structure

Nader Noroozi Pesyan, Saman Mousavi, Ertan Şahin

Page range: 44-50

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Abstract

Two independent and consecutive intermolecular Michael addition of 1,3-dimethylbarbituric acid to 2,6-diarylidenecyclohexanone as an α,β-unsaturated ketone leads to synthesis of a new type of meso form 5,5′-((2-oxocyclohexane-1,3-diyl)bis(arylmethylene))bis(1,3-dimethylpyrimidine-2,4,6(1 H ,3 H ,5 H )-trione) in good yield. These compounds showed a 2D-polymeric structure via intermolecular H-bonds. Structure elucidation is carried out by 1 H NMR, 13 C NMR, FT-IR, and X-ray diffraction analyses. A plausible reaction mechanism is discussed. Graphical abstract

Open Access April 27, 2022

Ionic liquid-catalyzed synthesis of (1,4-benzoxazin-3-yl) malonate derivatives via cross-dehydrogenative-coupling reactions

Ali Sharifi, Maryam Moazami, Mohammad Saeed Abaee, Mojtaba Mirzaei

Page range: 51-57

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Abstract

A convenient C(sp 3 )–C(sp 3 ) oxidative dehydrogenative coupling reaction of 1,4-benzoxazin-2-ones with malonate esters was developed under mild conditions to obtain the respective ester malonates in high yields. Reactions take place in [omim]FeCl 4 , acting as both the solvent and the catalyst. Under [omim]Cl/FeCl 3 -DDQ conditions, derivatives of 1 coupled with malonate 2 to give the target molecules within 1–2 h time periods. The ionic liquid was recovered and reused in the next reactions without losing its efficiency. Graphical abstract

Open Access May 10, 2022

Synthesis of novel triiodide ionic liquid based on quaternary ammonium cation and its use as a solvent reagent under mild and solvent-free conditions

Mahnaz Sakhdari, Nadiya Koukabi, Mohammad Ali Zolfigol

Page range: 58-66

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Abstract

In this article, for the first time, N,N,N -triethyl-3-iodopropan-1-aminium triiodide [N 2223I ] [I 3 ] was synthesized and utilized as both a reagent and a solvent in combination with H 2 O 2 (35%) to convert aromatic compounds into their corresponding iodo derivatives. The iodination was accomplished in the absence of organic solvents, and in most instances, water was the sole extraction solvent used. The consumed reagent N,N,N -triethyl-3-iodopropan-1-aminium iodide was comfortably recycled. Graphical abstract

Open Access May 10, 2022

Eelectrosynthesis of benzothiazole derivatives via C–H thiolation

Reza Ahdenov, Ali Asghar Mohammadi, Somayeh Makarem, Salman Taheri, Hoda Mollabagher

Page range: 67-74

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Abstract

Benzothiazole derivatives are essential intermediates in synthesizing a wide variety of medical and pharmaceutical compounds, and there is a great demand for a simple and efficient method to synthesize benzothiazoles under mild reaction conditions. Organic electrosynthesis as an energy-efficient process represents an environmentally benign and safer method than traditional methods for organic synthesis. Herein, we present bromine-free and straightforward synthesis of 2-amino benzothiazole derivatives via the reaction of aniline derivatives and ammonium thiocyanate using electrosynthesis in the presence of sodium bromide both as an electrolyte and as a brominating agent at room temperature in isopropyl alcohol (i-PrOH) as a solvent. The reaction of ammonium thiocyanate via C–H thiolation routes, using various aniline derivatives, resulted in a simple, green, and bromine-free synthesis of 2-amino benzothiazole in moderate to good yields under mild reaction conditions. Riluzole drug can be produced using the same procedure in moderate yields. Graphical abstract

Open Access June 15, 2022

Synthesis of fluoro-rich pyrimidine-5-carbonitriles as antitubercular agents against H37Rv receptor

Khushal M. Kapadiya, Kishor M. Kavadia, Vijay M. Khedkar, Piyush V. Dholaria, Amita J. Jivani, Ranjan C. Khunt

Page range: 75-83

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Abstract

The purpose of this study was to prepare various derivatives of 4-amino-2-(3-fluoro-5-(trifluoromethyl)phenyl)-6-arylpyrimidine-5-carbonitrile ( 6a–6h ) using a three-step procedure. The derivatives were screened in vitro for activity against Mycobacterium tuberculosis strain H37Rv . The activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL (μM). Eight compounds showed activity against Mtb H37Rv, and among them, 6f showed the best value of MIC, IC 50 (53 μM) and IC 90 (62 μM). Minimum bactericidal concentration of compound 6f was higher than its MIC and was more time-dependent than the concentration. Compound 6f was more active against M. tuberculosis H37Rv under low oxygen than metronidazole and did not show good potency in different treatments and non-tuberculous mycobacteria. Furthermore, a molecular docking study against mycobacterial enoyl-ACP reductase (InhA) could provide valuable insights into the plausible mechanism of action, which could set the theme for lead optimization. Graphical abstract

Open Access June 15, 2022

Syntheses, crystal structure, thermal behavior, and anti-tumor activity of three ternary metal complexes with 2-chloro-5-nitrobenzoic acid and heterocyclic compounds

Zhongyu Zhang, Meng Chen, Mingqiong Tong, Wan Sun, Pingxuan Dong, Xinfeng Song, Xiaoyue Wang

Page range: 84-94

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Abstract

Three complexes, namely complex ( 1 ), complex ( 2 ), and complex ( 3 ), were synthesized and characterized by X-ray diffraction, thermogravimetric study, and elemental study. Complex ( 1 ) comprises discrete binuclear clusters, where two oxygen atoms of 2-chloro-5-nitrobenzoic acid bridge the two copper atoms. Complex ( 2 ) is a six-coordination structure consisting of four nitrogen atoms and two oxygen atoms in 2-chloro-5-nitrobenzoic acid and 1,10-phenanthroline to furnish a twisted octahedron. Complex ( 3 ) is a six-coordination structure consisting of four oxygen atoms and two nitrogen atoms from the 2-chloro-5-nitrobenzoic acid, methanol, and 2,2′-dipyridyl to furnish a distorted octahedral geometry. Metal complexes’ anti-tumor activity was also investigated by the MTT assay. Of the complexes tested, complex ( 1 ) could induce apoptosis in these A549 lung cancer and Caco-2 colon adenocarcinoma cells and complex ( 2 ) could induce apoptosis in Caco-2 colon adenocarcinoma cells. CCDC for complex ( 1 ) was 1543354, CCDC for complex ( 2 ) was 1546991, and CCDC for complex ( 3 ) was 1543417.

Open Access August 15, 2022

Synthesis of enhanced lipid solubility of indomethacin derivatives for topical formulations

Murad Abualhasan, Nidal Jaradat, Raghad Maslamani, Dana Nofal, Linda Omar

Page range: 124-129

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Abstract

Indomethacin is a nonselective nonsteroidal anti-inflammatory drug with serious side effects such as depression, hallucination, and gastrointestinal irritation. This study aims to enhance indomethacin lipid solubility of indomethacin derivative to use it for the topical formulation since topical formulation may lower the unwanted side effects. The lipid solubility was achieved by adding various alkyl groups (methyl, ethyl, propyl, and isopropyl) to the drug via an ester linkage. The measured log p of these compounds was higher compared to the underivatized indomethacin. Furthermore, an ointment of each ester was formulated and was tested on mice skin using Franz diffusion. The best absorption was observed for methyl indomethacin with threefold increase in permeability compared to indomethacin. This study approves using derivatized indomethacin as a topical formulation with improved efficacy compared to the present gel formulation in the market.

Open Access September 27, 2022

Novel benzodioxatriaza and dibenzodioxadiazacrown compounds carrying 1,2,4-oxadiazole moiety

Besra Özer, Yaşar Dürüst

Page range: 139-148

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Abstract

A series of benzo (dibenzo)dioxadiaza and triazamacrocyclic ether compounds carrying 1,2,4-oxadiazole group has been successfully synthesized through N -substitution with 3- p -phenylsubstituted-5-chloromethyl-1,2,4-oxadiazoles. The structures of all the novel macrocycles were confirmed by spectral/physical data including HRMS measurements. Graphical abstract

Review Article

Open Access July 21, 2022

Chemical constituents of plants from the genus Carpesium

Ning-Ning Shi, Cong-Cong Hou, Yan Liu, Kun-Yao Li, Sheng-Dan Mi, Bin-Liang Tong, Man-Li Zhang

Page range: 95-123

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Abstract

Carpesium (Family – Compositae) is a genus with 24 species of mainly perennial herbs. Several species of this genus have served as folk medicine in China and Korea for their antipyretic, anti-inflammatory, analgesic, antifungal, antibacterial, and cytotoxic activity properties. Chemical constituents are mostly sesquiterpenes, diterpenes, glycosides, and several other types of compounds. This article summarizes the literature on the isolated and identified constituents from various Carpesium species and their various biological activities.

Volume 24 (2018)

Volume 23 (2017)

Volume 22 (2016)

Volume 21 (2015)

Volume 20 (2014)

Volume 19 (2013)

Volume 18 (2012)

Volume 17 (2011)

Volume 16 (2010)

Volume 15 (2009)

Volume 14 (2008)

Volume 13 (2007)

Volume 12 (2006)

Volume 11 (2005)

Volume 10 (2004)

Volume 9 (2003)

Volume 8 (2002)

Volume 7 (2001)

Volume 6 (2000)

Volume 5 (1999)

Volume 4 (1998)

Volume 3 (1997)

Volume 2 (1996)

Volume 1 (1995)

5-year Impact Factor	1.436
Cite Score	2.7
Impact Factor	2.000
Journal Citation Indicator	0.38
SCImago Journal Rank	0.300
Source Normalized Impact per Paper	0.661

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Manuscripts should be submitted to the journal via online submission system Editorial Manager available for this journal at https://www.editorialmanager.com/hcc In case of problems, please contact the Editorial Office of this journal at Izabela.Zarczynska@degruyter.com.

EDITORIAL POLICY

Unpublished material: Submission of a manuscript implies that the work described is not copyrighted, published or submitted elsewhere, except in abstract form. The corresponding author should ensure that all authors approve the manuscript before its submission.
Ethical conduct of research: The authors must describe and confirm safeguards to meet ethical standards when applicable. See Editorial Policy for details.
Conflict of interest: When authors submit a manuscript, they are responsible for recognizing and disclosing financial and/or other conflicts of interest that might bias their work and/or could inappropriately influence his/her judgment. If no specified acknowledgement is given, the Editors assume that no conflict of interest exists. Authors are encouraged to fill in the ICMJE Conflicts of Interest Form (available here) and send it in the electronic format to the Managing Editor.
Copyright: All authors retain copyright, unless – due to their local circumstances – their work is not copyrighted. The copyrights are governed by the Creative-Commons Attribution Only license (CC-BY) which is compliant with Plan-S. We may also publish a paper under CC-BY-NC-ND license on author's request. The corresponding author grants the journal the license to use of the article, by signing the License To Publish. Scanned copy of license should be sent to the journal, as soon as possible.
Authorship: Authorship should be limited to those who have made a significant contribution to the conception, design, execution, or interpretation of the reported study. All those who have made significant contributions should be listed as co-authors. Where there are others who have participated in certain substantive aspects of the research project, they should be named in an Acknowledgement section. The corresponding author should ensure that all appropriate co-authors (according to the above definition) and no inappropriate co-authors are included in the author list of the manuscript, and that all co-authors have seen and approved the final version of the paper and have agreed to its submission for publication.
Peer Review process: Our standard policy requires each paper to be reviewed by at least two Referees and the peer-review process is single-blind. The Editors reserve the right to decline the submitted manuscript without review, if the studies reported are not sufficiently novel or important to merit publication in the journal. Manuscripts deemed unsuitable (insufficient originality or of limited interest to the target audience) are returned to the author(s) without review. The Editor seeks advice from experts in the appropriate field. Research articles and communications are refereed by a minimum of two reviewers, review papers by at least three. Authors are requested to suggest persons competent to review their manuscript. However, please note that this will be treated only as a suggestion, and the final selection of reviewers is exclusively the Editor's decision. The final decision of acceptance in made by Managing Editor or, in case of conflict, by the Editor-in-Chief.
Scientific Misconduct: This journal publishes only original manuscripts that are not also published or going to be published elsewhere. Multiple submissions/publications, or redundant publications (re-packaging in different words of data already published by the same authors) will be rejected. If they are detected only after publication, the journal reserves the right to publish a Retraction Note. In each particular case Editors will follow COPE’s Core Practices and implement the advices.

Editorial

Editor-in Chief
Maged Henary, Department of Chemistry, Georgia State University, Atlanta, USA (mhenary1@gsu.edu)

Managing Editor
Izabela Żarczynska
Izabela.Zarczynska@degruyter.com

Honorary Editor
Lucjan Strekowski, Georgia State University, Atlanta, USA (lucjan@gsu.edu)

Associate Editors
Alfons Baumstark, Georgia State University, Atlanta, USA (abaumstark@gsu.edu)
Naresh Gunaganti, Northeastern University, Boston, USA (naresh.gunaganti@gmail.com)
Yuliang Li, Chang’an University, China (yulianglee175@chd.edu.cn)
Ajay Mallia, Georgia Gwinnett College, Lawrenceville, USA (amallia@ggc.edu)
Sarbjit Singh, University of Nebraska Medical Center, Nebraska, USA (sarbjit.singh@unmc.edu)
Kun Zhao, Chubu University, Kasugai, Japan (kunzhao13@gmail.com)
Wei Zhu, Northwestern University, Evanston, USA (wei.zhu@northwestern.edu)

Assistant Editor
Headar Abuirqeba, Catholic University of America, Washington DC, USA

Editorial Board
S. Abu-Orabi, Association of Arab Universities, Amman, Jordan (abuorabi@excite.com)
S. Achilefu, Washington University, St. Louis, USA (achilefus@mir.wustl.edu)
E.B. Arevalo-Garcia, Educational Research Institute, Warsaw, Poland (ebarevalog@gmail.com)
M. Brimble, University of Auckland, Auckland, New Zealand (m.brimble@auckland.ac.nz)
R.A. Bunce, Oklahoma State University, Stillwater, USA (rab@okstate.edu)
D. Das, Johns Hopkins School of Medicine, Baltimore, USA (ddas7@jhmi.edu)
M. Elliott, University of Cardiff, Cardiff, UK (elliottmc@cardiff.ac.uk)
D.C. Gautam, University of Rajasthan, Jaipur, India (drdcgautam@yahoo.co.in)
M.W. Germann, Georgia State University, Atlanta, USA (mwg@gsu.edu)
S. Gozem, Georgia State University, Atlanta, USA (sgozem@gsu.edu)
D. Hamelberg, Georgia State University, Atlanta, USA (dhamelberg@gsu.edu)
H. Kiyota, Okayama University, Okayama, Japan (kiyota@okayama-u.ac.jp)
K. Kiec-Kononowicz, Jagiellonian University, Kraków, Poland (mfkonono@cyf-kr.edu.pl)
M. Kumar, University of Rajasthan, Jaipur, India (mahendrakpathak@gmail.com)
H. Nishino, Kumamoto University, Kumamoto, Japan (nishino@sci.kumamoto-u.ac.jp)
T. Okano, Jikei University, Tokyo, Japan (okano@jikei.ac.jp)
S.S. Panda, Augusta University, Augusta, USA (sipanda@augusta.edu)
S.E. Patterson, UMN Center for Drug Design, Minneapolis, USA (patte219@umn.edu)
J. Reddy, Dr. Jagath Reddy's Heterocyclics, Hyderabad, India (jagathreddy@heterocyclics.com)
S. Routier, University of Orléans, Orléans, France (sylvain.routier@univ-orleans.fr)
A. Rykowski, University of Podlasie, Siedlce, Poland (rykowski@ap.siedlce.pl)
F. Saczewski, Medical University of Gdansk, Gdansk, Poland (saczew@amg.gda.pl)
S.W. Schneller, University of Auburn, Auburn, USA (schnest@auburn.edu)
B.C.G. Söderberg, University of West Virginia, Morgantown, USA (bjorn.soderberg@mail.wvu.edu)
V. Traven, Russian University of Chemical Technology, Moscow, Russia (traven@muctr.edu.ru)
B. Wang, Georgia State University, Atlanta, USA (wang@gsu.edu)
K. Weisz, Ernst Moritz Arndt University, Greifswald, Germany (weisz@uni-greifswald.de)
P.-F. Xu, Lanzhou University, Lanzhou, China (xupf@lzu.edu.cn)
P. Zajdel, Jagiellonian University Medical College, Kraków, Poland (pawel.zajdel@uj.edu.pl)
N. Zaware, Mount Sinai School of Medicine, New York, USA (nzaware@gmail.com)
A. Zawisza, University of Łódź, Łódź, Poland (aniazawisza@poczta.onet.pl)

Language Editors
Stephen Hill, The ōbex project, UK
Alison Jones, The ōbex project, UK
Joanna Cave, The ōbex project, UK
Rosie Madge, The ōbex project, UK
Martin Owton, The ōbex project, UK
Hugh Patrick, The ōbex project, UK
Nour Tanbouza, The ōbex project, UK
Amy Catherine Angie Verhagen, The ōbex project, UK
Rebecca Williams, The ōbex project, UK
Rachel Whiteside, The ōbex project, UK

Publisher
DE GRUYTER Poland
Bogumiła Zuga 32A Str.
01-811 Warsaw, Poland
T: +48 22 701 50 15

Editorial Contact
Izabela Żarczynska
Izabela.Zarczynska@degruyter.com

(Deutsch)

Type: Journal
Language: English
Publisher: De Gruyter
First published: January 1, 1994
Publication Frequency: 6 Issues per Year
Audience: researchers in the field of heterocyclic, bioorganic, bioinorganic and medicinal chemistry