The aim of the present study was to analyze the link between the five moral codes proposed in the Moral Foundations Theory and moral judgment of disparagement humor. We presented racist, sexist, homophobic, religion-disparaging and neutral jokes to a group of 108 participants, asking them whether they found laughing at a particular joke moral or immoral. Additionally, participants rated the level of amusement and disgust evoked by each joke. We also measured participants’ moral foundations profiles (Care, Fairness, Loyalty, Authority, and Sanctity). The results confirmed that Care and Fairness were significantly linked to moral judgment of racist, sexist and homophobic jokes, whereas Loyalty, Authority and Sanctity were associated with moral judgment of religion-disparaging jokes. Moreover, these relationships were mediated by emotional responses of amusement and disgust (except for racist jokes, for which we observed no mediating role of amusement).