Background: Pesticides, particularly when misused, can cause serious morbidity and mortality. There is limited literature on pesticide exposures among adolescents. Objective: The purpose of this study was to describe adolescent pesticide exposures reported to poison centers and compare them to adult exposures. Subjects: Pesticide exposures reported to Texas poison centers during 2000–2013 where the patient was age 13 years or greater. Methods: Cases were divided into adolescents (13–19 years) and adults (20 years or more). The distribution of the cases was determined for various factors, and comparisons were made between the two age groups. Results: There were 2772 adolescent and 33,573 adult pesticide exposures. The most common types of pesticide among adolescent and adult cases, respectively, were insecticides (71% vs. 76%), herbicides (6% vs. 9%), repellents (11% vs. 8%), and rodenticides (10% vs. 5%). Adolescent patients were 56% male and 43% female; adult patients were 45% male and 55% female. The most common exposure routes among adolescent and adult cases, respectively, were dermal (29% vs. 38%), inhalation (22% vs. 33%), ingestion (47% vs. 29%), and ocular (14% vs. 13%). The exposure reason for adolescent and adult exposures, respectively, were unintentional (82% vs. 89%), intentional (13% vs. 7%), adverse reaction (2% vs. 3%), and other/unknown (3% vs. 1%). Conclusion: Compared to adult exposures, adolescent pesticide exposures were more likely to involve repellents and rodenticides, involve males, occur by ingestion, and be intentional.