This article reports on the current status and key findings of a growing body of empirical research on humility; argues for further interdisciplinary, collaborative research between empirical psychology and practical theology; and outlines several generative future research trajectories. Scientific studies of humility could be quite relevant to practical theology, particularly informing research on spiritual formation, intercultural competence, theological education, leadership development, and clinical care. At the same time, we argue for increased attention to theology and spirituality in psychological research on humility, particularly given the strong role of religious and spiritual traditions/communities in promoting humility as a virtue and recent feminist practical theological critiques of humility constructions. Engagement between social scientists and theologians enables sharper reflection upon the moral values implicit in the expanding body of empirical research on humility. Such collaborative, interdisciplinary work is essential in shaping research-based interventions in clinical and religious practice.