journal: BioInorganic Reaction Mechanisms

Eingestellt

Veröffentlicht von 1. November 2003 bis 1. Dezember 2013

BioInorganic Reaction Mechanisms

ISSN: 2191-2491

Editor-in-Chief: Ivana Ivanovic-Burmazovic

Über diese Zeitschrift

The demand for new catalytic and biorelevant processes that can offer solutions for more efficient energy use, organic syntheses, utilization of alternative fuels and manipulation of pathological and disease states is constantly increasing. The elucidation of the reaction paths, intermediates and mechanisms behind the desired reactivity of metal centers in bio/inorganic molecules and materials is absolutely essential and deserves a special scientific platform to be properly addressed. BioInorganic Reaction Mechanisms offers this important platform as the primary specialized international journal in the field of reactions and mechanisms of inorganic and bioinorganic systems. In dealing widely with reactions of metal centers, this quarterly, peer-reviewed journal will accept papers pertaining to the areas of coordination chemistry, organometallic chemistry, main group chemistry and bioinorganic chemistry. It publishes original papers reporting the results of original significant studies in the general area of kinetics and mechanisms of bioinorganic reactions in solution, and also of studies designed to define reaction pathways or mechanisms via detection and characterization of intermediates by spectroscopic or structural means, as well as via utilization of theoretical/computational approaches. Papers dealing with advances in the determination or processing of data pertaining to mechanistic studies are also welcome.

About BIRM – the forum for your specialist studies in the broad field of inorganic and bioinorganic reactions and mechanisms:

BIRM accepts papers pertaining to the areas of coordination chemistry, organometallic chemistry, main group chemistry and bioinorganic chemistry. It publishes papers relating to mechanistic studies in the broadest sense, not solely detailed examinations of reaction kinetics.

The journal publishes both full papers, reporting the results of substantial independent study, short communications, reporting the results of completed studies of lesser scope than full papers, and short topical reviews. Those authors contemplating a review article should contact the editors initially. A size limit will apply to short communications.

Previously published by Old City Publishing.

Publication ceased end of 2013.

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Fachgebiete

Band 9 Heft 1-4

Dezember 2013

Öffentlich zugänglich 8. Januar 2014

Cover and Frontmatter

Seiten: i-iii

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Editorial

8. Januar 2014

Special issue on Medicinal Redox Inorganic Chemistry

Ivana Ivanović-Burmazović

Seiten: 1-2

Reviews

9. August 2013

Texaphyrins and water-soluble zinc(II) ionophores: development, mechanism of anticancer activity, and synergistic effects

Christian Preihs, Darren J. Magda, Jonathan L. Sessler

Seiten: 3-14

Mehr

Abstract

Texaphyrins, first prepared by Sessler and coworkers in the 1980s, represent early examples of expanded porphyrins. This class of pentaaza, oligopyrrolic macrocycles demonstrates excellent tumor localization and metal-chelating properties. In biological milieus, texaphyrins act as redox mediators and are able to produce reactive oxygen species. Furthermore, texaphyrins have been shown to upregulate zinc in vivo , an important feature that inspired us to develop new zinc ionophores that might allow the same function to be elicited but via a simpler chemical means. In this review, the basic properties of texaphyrins and the zinc ionophores they helped spawn will be discussed in the cadre of developing an understanding that could lead to the preparation of new, redox-active anticancer agents.

9. September 2013

Macrophage activation by apoptotic cells

Bernhard Brüne, Andreas von Knethen

Seiten: 15-25

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Abstract

Macrophages sense exogenous/endogenous danger signals due to their high functional plasticity and adjust their output signals accordingly. These comprise immune responses with the formation of reactive oxygen species, nitric oxide and pro-inflammatory cytokines, with the assumption that reactive species compose a redox signalling network. However, alternatively polarised macrophages suppress toxic radical formation, producing anti-inflammatory signatures associated with tissue repair, immune modulation, and angiogenesis. To change their mediator profile, we describe macrophage subsets and their response to apoptotic cells, focusing on reactive oxygen/nitrogen species and signalling mechanisms, and how apoptotic cells polarise macrophages to adopt an immune-regulatory, pro-angiogenic, and tumour-promoting phenotype.

8. Januar 2014

The redox properties of the unique heme in cystathionine β-synthase

Ernesto Cuevasanta, Sebastián Carballal, Martín Graña, Beatriz Alvarez

Seiten: 27-34

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Abstract

Cystathionine β-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and H 2 O or H 2 S. Human CBS has a non-catalytic heme bound to cysteine and histidine. The heme environment is conserved among several eukaryotic species but does not resemble any other protein. Fe(III)-CBS is relatively unreactive; however, reduction to Fe(II)-CBS can be achieved by strong chemical and biochemical reductants. Once reduced, Fe(II)-CBS can react with CO, which leads to a carbonylated and inactive species. Fe(II)-CBS can also be reoxidized by oxygen back to Fe(III)-CBS, thus forming superoxide radical. Kinetic considerations favor reoxidation unless this occurs under very low oxygen concentrations.

8. Januar 2014

The complex mechanistic aspects of redox-active compounds, commonly regarded as SOD mimics

Ines Batinic-Haberle, Artak Tovmasyan, Ivan Spasojevic

Seiten: 35-58

Mehr

Abstract

This review aims to clarify (1) what is a true mimic of superoxide dismutase family of enzymes, SOD; and (2) whether such compound could act as SOD mimic in a complex biological milieu. Several groups of compounds (metalloporphyrins, metallocorroles, Mn biliverdins, Mn cyclic polyamines, Mn salens, and metal oxides and salts) have been described. Their ability to catalyze the dismutation of O 2 ·– , [ k cat (O 2 ·– )], thermodynamic property that supports high catalytic ability ( E 1/2 ), kinetic factors that facilitate the catalysis, and the stability of compounds, which assures the integrity of metal coordination sphere where reactions of interest occur have been discussed. The other possible in vivo actions of those compounds, such as peroxynitrite and hypochlorite reduction, peroxidase-like activity, thiol oxidase activity etc., have been described as well. Based on in vivo studies it appears that k cat (O 2 ·– ) for Mn(III) N-substituted pyridylporphyrins parallels their therapeutic ability. The reason for that lies in their electrophilic nature which favors reactions with nucleophilic (anionic) reactive species (O 2 ·– , ONOO – , ClO – , HO 2 – , CO 3 ·– ) and simple or protein thiolates. Their in vivo multiple rather than single modes of actions, would be determined by: (a) their redox properties; (b) localization at targeted cellular site; and (c) redox environment of diseased or mutated/cancer cell. Quality of any drug preparation and the knowledge of researchers on its properties are essential when its mechanistic aspects are explored.

Short Communication

8. Januar 2014

Standard electrode potentials involving radicals in aqueous solution: inorganic radicals

David A. Armstrong, Robert E. Huie, Sergei Lymar, Willem H. Koppenol, Gabor Merényi, Pedatsur Neta, David M. Stanbury, Sten Steenken, Peter Wardman

Seiten: 59-61

Mehr

Abstract

Inorganic radicals, such as superoxide and hydroxyl, play an important role in biology. Their tendency to oxidize or to reduce other compounds has been studied by pulse radiolysis; electrode potentials can be derived when equilibrium is established with a well-known reference compound. An IUPAC Task Group has evaluated the literature and produced the recommended standard electrode potentials for such couples as (O 2 /O 2 ·- ), (HO · , H + /H 2 O), (O 3 /O 3 ·- ), (Cl 2 /Cl 2 ·- ), (Br 2 ·- /2Br - ), (NO 2 · /NO 2 - ), and (CO 3 ·- /CO 3 2- ).

Abstracts

8. Januar 2014

MEDICINAL REDOX INORGANIC CHEMISTRY CONFERENCE 2013

Seiten: S1-S105

Band 9 (2013)

Heft 1-4 Special issue: Medicinal Redox Inorganic Chemistry

Band 8 (2012)

Band 7 (2011)

Heft 1-4

Band 6 (2008)

Band 5 (2005)

Band 3 (2001)

Heft 1

Band 1 (2000)

Für diese Zeitschrift sind keine Journal Metrics verfügbar.

Editorial

Editor-in-Chief
Ivana Ivanovic-Burmazovic, Erlangen, Germany

Co-Editors
Shunichi Fukuzumi, Osaka, Japan
Richard Henderson, Newcastle-upon-Tyne, UK

Editorial Board
Mahdi M. Abu-Omar, West Lafayette, USA
Andreja Bakac, Ames, USA
Lisa Berreau, Logan, USA
Peter C. Ford, Santa Barbara, USA
Jeremy Harvey, Bristol, UK
Willem Koppenol, Zürich, Switzerland
Gabor Laurenczy, Lausanne, Switzerland
Wojciech Macyk, Krakow, Poland
Wonwoo Nam, Seoul, Korea
Christian Obinger, Vienna, Austria
Alexander D. Ryabov, Pittsburgh, USA
David Stanbury, Auburn, USA
Felix Tuczek, Kiel, Germany
Rudi van Eldik, Erlangen, Germany

(English)

Online ISSN: 2191-2491
Typ: Zeitschrift
Sprache: Englisch
Verlag: De Gruyter
Erstveröffentlichung: 1. November 2003
Letzte Veröffentlichung: 1. Dezember 2013
Erscheinungsweise: 4 Hefte pro Jahr
Zielgruppe: Researchers in inorganic chemistry, metallorganic chemistry, bioinorganic chemistry and medicinal chemistry