Published since December 1, 1986

Journal of Basic and Clinical Physiology and Pharmacology

ISSN: 2191-0286

Editor-in-chief: Ugo Oliviero

Managing Editor: Alberto Marra

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About this journal

Objective
The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including Emergency Medicine, Oncology, Hematology and Coagulation disorders, Vascular Medicine, Gastroenterology, Liver Disease, Neurology and Cerebrovascular Diseases, Gender Medicine, Endocrinology, Diabetology and Metabolism, Cardiovascular Diseases, Heart Failure, Respiratory Disease, Geriatrics, Immunology and Rheumatology.

Moreover, Manuscripts regarding basic and laboratory sciences will be very welcome.

As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes.　

Topics

Emergency Medicine
Oncology
Hematology and Coagulation disorders
Vascular Medicine
Gastroenterology
Liver Disease
Neurology and Cerebrovascular Diseases
Gender Medicine
Endocrinology
Diabetology and Metabolism
Cardiovascular Diseases
Heart Failure
Respiratory Disease
Geriatrics
Immunology
Rheumatology

Article formats
Research Articles, Reviews and Mini Reviews, Short Communications, Editorials and Letters to the Editor

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State-of-the-art research in physiology and pharmacology
Integrative approach to descriptive and behavioral studies
Leading-edge techniques
High quality peer-review

History

Founded in 1990
Increase of contents and issue numbers from 4 to 6 in 2015
Online-only as of 2019

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Volume 34 Issue 5

September 2023

Publicly Available September 21, 2023

Frontmatter

Page range: i-ii

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Editorials

August 24, 2023

Deiodination and tumor progression: the interplay between thyroid hormones intracellular activation and the androgen signal

Serena Sagliocchi, Lucia Acampora, Annunziata Gaetana Cicatiello

Page range: 551-553

August 18, 2023

The intricate role of glutamine in pathophysiological contexts

Annarita Nappi, Caterina Miro

Page range: 555-557

Reviews

October 18, 2021

Zebrafish as a model organism – can a fish mimic human?

Subhiksha Subramanian

Page range: 559-575

Abstract

From pre-historic era, all scientific discoveries have evolved around a concept – THINK BIG but for a change zebrafish as a model organism in research had managed to halt the entire medical community and made us realize that it’s time to think small. From a barely imagined being in research few years ago to around 4,000 publications in just last year, zebrafish has definitely come a long way. Through these tiny fish, scientists have managed to find genes that caused human diseases and have also developed various specific models to know more about the pathology behind such diseases. This review will focus on zebrafish as a model organism from the time it was introduced to the most novel targets with particular emphasis on central nervous system (CNS) as it is rapidly evolving branch in zebrafish research these days. This review will try to shed light on the early stages of zebrafish as a model organism and will try to cover the journey of it developing as a successful model organism to map many diseases like diabetes, Alzheimer’s and autism describing the rationale for using this specific model and briefly the techniques under each category and finally will summarize the pros and cons of the model with its expected future directions.

November 15, 2021

Phytocompounds and their molecular targets in immunomodulation: a review

Ayda Cherian, Velmurugan Vadivel, Sundarrajan Thiruganasambandham, Sreejith Madhavankutty

Page range: 577-590

Abstract

Immune cells are important for the healthy function of every organ. The homeostasis of the immune system is selfregulated by T-cells, B-cells, and natural killer cells. The immunomodulation process of immune cells is part of the immunotherapy. According to therapeutic methods of immune responses are categorized as inducing (immunostimulant), amplification (immune booster), attenuation (immunomodulation), and prevention (immunosuppressive) actions. The prevalence of chronic immunological diseases like viral infections, allergies, and cancer is mainly due to the over-activation of the immune system. Further, immunomodulators are reported to manage the severity of chronic immunological disorders. Moreover, these immunomodulator-acting proteins are identified as potential molecular targets for the regulation of the immune system. Moreover, natural compound like phytocompounds are known to bind these targets and modulates the immune system. The specialized phytocompounds like curcumin, quercetin, stilbenes, flavonoids, and lignans are shown the immunomodulatory actions and ameliorate the immunological disorders. The present scenario of a COVID-19 pandemic situation has taught us the need to focus on strengthening the immune system and the development of the most promising immunotherapeutics. This review is focused on an overview of various phytocompounds and their molecular targets for the management of immunological disorders via immunosuppressants and immunostimulants actions.

Original Articles

June 22, 2021

Host–parasite relationship modulates the effect of African mistletoe leaves on the cholinergic, monoaminergic and carbohydrate hydrolyzing enzymes in fruit fly

Olubukola H. Oyeniran, Adedayo O. Ademiluyi, Ganiyu Oboh

Page range: 591-601

Abstract

Objectives Mistletoe infests common plant trees of great medicinal values such as Moringa and Almond. According to folklore, mistletoe leaves have been found to have application as food and medicine in the alleviation of various degenerative diseases. Host–parasite relationship may possibly influence the phytochemical and biological activities of mistletoe leaves. Hence, we examined the polyphenol contents, antioxidant properties, α-amylase, α-glucosidase, acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitory activities of African mistletoe leaves obtained from Moringa and Almond host plants in fruit fly in vitro . Methods The phenolic constituents of the leaves were evaluated using HPLC system. The antioxidant activities were determined through the ABTS, DPPH and OH free radicals scavenging properties, ferric (Fe 3+ ) and malondialdehyde (MDA) reducing abilities and Fe 2+ chelation. The inhibitory effects of the leaves aqueous extracts on α-amylase, α-glucosidase, AChE and MAO activities were also assessed. Results The HPLC characterization of the leaves revealed that host plants caused marked variation in their phenolic composition, however, Almond mistletoe leaves had significantly (p<0.05) greater amounts of phenolic constituents. Both Moringa and Almond mistletoe leaves reduced Fe 3+ and MDA levels, scavenged free radicals, chelated Fe 2+ and inhibited α-amylase, α-glucosidase, AChE and MAO activities with the Almond mistletoe leaves having significantly (p<0.05) higher antioxidant properties and enzyme inhibitory activities. Conclusions This present study indicated that host plants could positively modulate the phenolic profile of mistletoe leaves and this probably brought about the vivid noticeable changes in their antioxidant abilities, cholinergic, monoaminergic and carbohydrate hydrolyzing enzymes inhibitory activities.

June 21, 2021

Behavioral and biochemical investigations to explore the efficacy of quercetin and folacin in experimental diabetes induced vascular endothelium dysfunction and associated dementia in rats

Poonam Sharma, Khushboo Aggarwal, Rajendra Awasthi, Giriraj T. Kulkarni, Bhupesh Sharma

Page range: 603-615

Abstract

Objectives Vascular dementia (VaD), being strongly associated with metabolic conditions is a major health concern around the world. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of quercetin and folacin in diabetes induced vascular endothelium dysfunction and related dementia. Methods Single dose streptozotocin (STZ) (50 mg/kg i.p) was administered to albino Wistar rats (male, 200–250 g) by dissolving in citrate buffer. Morris water maze (MWM) and attentional set shifting tests were used to assess the spatial learning, memory, reversal learning, and executive functioning in animals. Body weight, serum glucose, serum nitrite/nitrate, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), mitochondrial enzyme complex (I, II, and IV), inflammatory markers (interleukin-IL-6, IL-10, tumor necrosis factor-TNF-α, and myeloperoxidase-MPO), and acetylcholinesterase activity-AChE were also assessed. Quercetin (30 mg kg −1 /60 mg kg −1 ) and folacin (30 mg kg −1 /60 mg kg −1 ) were used as the treatment drugs. Donepezil (0.5 mg kg −1 ) was used as a positive control. Results STZ administered rats showed reduction in learning, memory, reversal learning, executive functioning, impairment in endothelial function, increase in brains’ oxidative stress; inflammation; AChE activity, and decrease in mitochondrial complex (I, II, and IV) activity. Administration of quercetin and folacin in two different doses, significantly attenuated the STZ induced diabetes induced impairments in the behavioral, endothelial, and biochemical parameters. Conclusions STZ administration caused diabetes and VaD which was attenuated by the administration of quercetin and folacin. Therefore, these agents may be studied further for the assessment of their full potential in diabetes induced VaD conditions.

June 28, 2021

Chronic exposure of industrial grade calcium carbide and ethylene glycol exert genotoxic effect in Wistar albino rats

Markose Bini, Bhargavan Rajesh, Thekkekara Devassy Babu

Page range: 617-623

Abstract

Objectives Calcium carbide (CaC 2 ) and ethylene glycol (EG) are the two commonly used fruit ripening agents. The toxic effects of these chemicals on internal organs were reported in experimental animals. Even though the adverse effects of these compounds have been investigated for many years, there are no sufficient data available with regard to genotoxic effects. The present study evaluates the genotoxic effect of chronic exposures of CaC 2 and EG in Wistar albino rats. Methods CaC 2 and EG were administered to the rats orally for 180 days. Chromosomal aberrations and micronuclei formation were analysed in bone marrow and peripheral blood cells. Comet assay was performed to analyse the DNA strand break. The toxic effects of the chemicals were analysed by MTT assay with normal human intestinal epithelial (IEC-6) cells. Results Upon chronic exposure, CaC 2 and EG caused chromosomal aberrations, micronuclei formation and DNA strand breaks extensively in bone marrow and peripheral blood cells. In MTT assay, the chemicals were found to be toxic to IEC-6 cells with IC 50 values at 160 and 200 μg/mL for CaC 2 and EG, respectively. Conclusions The results show that these chemicals have a potential to cause genomic level of toxicity which may lead to carcinogenic event at a chronic level exposure. The study warns to reinforce the administrative measures against the use of CaC 2 and EG for fruit ripening process. Highlights – Industrial grade CaC 2 and EG show genotoxicity at the chronic exposure in animals at lower doses. – In vitro cytotoxicity by CaC 2 and EG towards IEC-6 cell line exhibited dose dependent decrease of cell proliferation. – Chromosomal aberrations, micronuclei formation, DNA breakage (comet assay) suggest potentially pre-mutagenic lesions by the toxicity. – These chemicals have the potential for genotoxic and carcinogenic effect. – The study warns the health risks of consumption of fruits ripened with calcium carbide and ethylene glycol.

June 18, 2021

A four-year review of uterine rupture at a secondary health facility in Okitipupa, Southwest Nigeria

Akadiri Olumide, Ibitoye B. Oluwaseun, Akintan A. Lawrence, Olaniyan T. Olugbemi, Omotayo S. Ramon

Page range: 625-628

Abstract

Objectives Uterine rupture in pregnancy is an obstetric emergency especially in developing countries associated with a significant increase in maternal plus perinatal mortality and morbidity. There is a need to identify the prevalence together with underlining factors which could guide effective intervention. Hence, the study aimed at determining the prevalence of uterine rupture, predisposing factors, management options plus clinical presentation at Secondary Health Facility in Okitipupa, South West Nigeria. Methods This was a retrospective study of patients with a uterine rupture from January 2009 to December 2012 in the Department of Obstetrics and Gynaecology State Specialist Hospital Okitipupa. The case records of patients in this period were retrieved from the medical health records department and relevant data of sociodemographic characteristics, clinical presentation, management as well as maternal and perinatal outcome were collated using a structured questionnaire. Data were analyzed using Microsoft Excel version 10. Results Of the 11,377 deliveries during the study period a total of 52 uterine ruptures were recorded during the same period making an incidence of 0.46% or a ratio of 1:219 deliveries. Most of the patients 28 (60.9%) were 20–30 years of age. Uterine rupture was more common amongst multiparous women 36 (78.3%). None was a primigravida. The majority of the patients 34 (73.9%) were nonattendants at the antenatal clinic. The commonest single predisposing factor was the presence of a previous scar being present in 12 (26.1%) of the patients. The most common surgery performed for uterine rupture in the series was repair only 24 (52.2%). There is an absence of uterine rupture in primigravida supports the belief that primigravida is somehow immune to rupture. Conclusions Rupture of the gravid uterus is a major contributor to maternal and perinatal mortality in Okitipupa Southwest Nigeria.

June 18, 2021

Increased nitric oxide availability worsens the cardiac performance during early re-perfusion period in adult rats

Faten M.A. Diab, Mahmoud H. Ayobe, Mohamed F. Abdel-Salam, Mohammed F.S. Otman, Enas A. Abdel-Hady

Page range: 629-637

Abstract

Objectives Re-perfusion is the standard therapy for acute myocardial infarction, despite the associated pathologies that may contribute to irreversible myocardial injury. The present study aims to clarify the alterations in cardiac activities in response to experimental cardiac ischemic arrest followed by re-perfusion in isolated hearts perfused with nitric oxide (NO) donor, l -arginine, or NO inhibitor, Nω-Nitro- l -arginine methyl ester hydrochloride ( l -NAME), to shed light on the possible role of NO in the re-perfusion process. Methods Hearts isolated from adult Wistar rats were studied on Langendorff preparation under basal conditions and during 30 min re-perfusion following 30 min of total global ischemia. Rats were randomly divided into three groups; control and l -arginine or l -NAME infused heart groups. Cardiac tissue content of malondialdhyde, catalase and nitrite was also measured. Results Compared to the control group, both l -arginine and l -NAME infused hearts showed increased basal chronotropy and myocardial flow rate. Following ischemia and during the whole period of re-perfusion, the three groups demonstrated significant deterioration in the inotropic activity and compromised myocardial flow rate. l -arginine infused hearts revealed depressed inotropy and chronotropy, weak systolic and diastolic functions with compromised myocardial flow at early 5 min of re-perfusion, yet with significantly higher myocardial flow rate by the end of re-perfusion. Conclusions Reducing NO availability by l -NAME revealed mild impact on the ischemia re-perfusion induced contractile dysfunction, whereas excess NO worsens cardiac performance at the early re-perfusion period.

June 25, 2021

Safety evaluation of an antimalarial herbal product from Andrographis paniculata (AS201-01) in healthy volunteers

Aty Widyawaruyanti, Arijanto Jonosewojo, Hilkatul Ilmi, Lidya Tumewu, Ario Imandiri, Endang Widiastuti, Lilis Dachliyati, Muhammad F Budiman, Dwi Setyawan, Achmad F Hafid, Indah S Tantular

Page range: 639-645

Abstract

Objectives Andrographis paniculata tablets (AS201-01) have previously been shown to have potent bioactivity as an antimalarial and to produce no unwanted side effects in animal models. Here, we present the phase 1 clinical trial conducted to evaluate the safety of AS201-01 tablets in healthy volunteers. Methods The study was a randomized, double-blind controlled cross-over, a placebo-controlled design consisting of a 4-day treatment of AS201-01 tablets. A total of 30 healthy human volunteers (16 males and 14 females) were divided into two groups, and each group was given 4 tablets, twice daily for 4 days. Group 1 received AS201-01, while group 2 received placebo tablets. Volunteers were given a physical examination before the treatment. The effects of AS201-01 on random blood glucose, biochemical, and hematological as well as urine profiles were investigated. Results There were no changes in observed parameters as a result of AS201-01 being administered. Statistical analysis showed no significant difference (p>0.05) between the test and control group regarding hematology profile, biochemical profile, and random blood glucose. Increased appetite and better sleep, which categorized as grade 1 adverse event was reported after treatment with AS201-01 tablet Conclusions The outcome supports our previous observation that the AS201-01 tablet, given twice a day for 4 days, is safe and nontoxic.

August 2, 2021

Tobacco use and clinical leukoplakia lesions among south Indian tribes

Amina Shajahan, Abel Chundankuzhiyil Mathew, Vadavattath Padmanabhan Gangadharan, Dilip Chandrasekhar

Page range: 647-654

Abstract

Objectives Leukoplakia is a white mucosal thickening and perhaps undermining change in the oral mucosa transcendently found in tobacco users. Since the tobacco utilization is extensively higher with the indigenous groups in the Asia Pacific locale, the current examination implicated the prevalence of tobacco consumption and leukoplakial lesions and the relationship between the two. Methods This cross-sectional study was conducted through six tribal hamlets of Chithalayath Forest range at Wayanad district of Kerala, South India. Leukoplakia screening was led by a senior consultant on the basis of a visual investigation and pathological evaluation was not done. An organized questionnaire was utilized to gather data on demographic details and tobacco usage status and frequency. The prevalence of clinical oral lesions among tobacco users and non users was determined using statistical analysis. Results Clinical oral leukoplakia was diagnosed in 27 (8.5%) subjects among the 317 individuals screened. The prevalence of lesions was considerably higher among tobacco consumers in comparison with non users (11 vs. 3.7%). Also, the tobacco chewers group had a higher percentage of leukoplakia. Another significant finding of this study is that the incidence of provisional leukoplakia was observed to be comparatively high among the most frequent tobacco consumers 15 (65.2%) in comparison with 8 (34.8%) in the frequent and nonfrequent users. Conclusions Prevalence of abusive habits and clinical oral leukoplakial was substantial among the tribes. The cause and effect relationship and dose-response were also shown to have a significant association.

August 4, 2021

Carcinogen sodium arsenite disrupts antioxidant and redox homeostasis in Drosophila melanogaster

Aghogho Oyibo, Amos O. Abolaji, Oyeronke A. Odunola

Page range: 655-662

Abstract

Objectives The inadvertent exposure to environmental contaminants has been reported to induce cancer in different animal models. Here, we investigated the toxicity of Sodium Arsenite (SA), a Class I Carcinogen in Drosophila melanogaster . Methods Harwich fly strain (1–3 days old) of both sexes were orally exposed to SA (0, 0.0312, 0.0625 and 0.125 mM) for 14 days for survival study. Thereafter, 5 days exposure period was selected to assess the toxic effects of SA on oxidative stress and antioxidant markers. Results The results indicated that SA induced significant reduction in survival and emergence rate of flies. Furthermore, SA significantly increased Nitric Oxide (NO, nitrite and nitrate) and Hydrogen Peroxide (H 2 O 2 ) levels in flies compared with control (p<0.05). In addition, SA inhibited catalase and glutathione-S-transferase (GST) activities, and depleted total thiol and glutathione (GSH) contents. Moreover, acetylcholinesterase activity significantly increased in flies treated with SA when compared with control. Conclusions Sodium arsenite-induced reduction in survival and emergence rates of flies occurred via the disruption of oxidative stress-antioxidant homeostasis in D. melanogaster .

March 28, 2022

No association of the common Asian mitochondrial DNA haplogroups with lung cancer in East Indian population

Tania Saha, Bismoy Bhowmick, Debmalya Sengupta, Souradeep Banerjee, Ritabrata Mitra, Abhijit Sarkar, Tamohan Chaudhuri, Gautam Bhattacharjee, Somsubhra Nath, Susanta Roychoudhury, Mainak Sengupta

Page range: 663-668

Abstract

Objectives Mitochondrial dysfunction has long been associated with the pathogenesis of lung cancer (LC). Mitochondrial DNA (mtDNA) haplogroups have been reported to modify the risk of LC in a few different populations; however, no study has been done among the Indians. Here, we explore the relationship between mtDNA haplogroups and LC in a representative eastern Indian sample set. Methods Different combinations of six mtDNA SNPs, which define the major Asian mtDNA haplogroups M and N, and their sub-haplogroups D, G, M7, R, and F were genotyped via polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) – sequencing approach in 94 smoker LC patients and 100 healthy smoker controls from an eastern Indian cohort. Results The distribution of 7 mtDNA haplogroups did not show any significant differences between patients and controls (p<0.05). We did not find sub-haplogroup M7 in our study population. Conclusions Our study is the first to indicate that the major Asian mtDNA haplogroups have no significant (p < 0.05) association with LC in East Indian population.

May 24, 2022

Cardioprotective effect of Justicia gendarussa on doxorubicin induced toxicity in mice

Sreepriya P. K., Fijesh P. Vijayan, Chennattu M. Pareeth, Jose Padikkala, Thekkekara Devassy Babu

Page range: 669-675

Abstract

Justicia gendarussa Burm.f, belonging to the family Acanthaceae, is widely used for various ailments traditionally. Antioxidant, anti-arthritic, anti-inflammatory, analgesic, anticancerous, properties of the plant have been widely reported. The present study analyzed the cardioprotective effect of J. gendarussa on doxorubicin (DOX) induced toxicity in mice. Ethanolic extract of J. gendarussa was administered orally for 7 consecutive days. The alterations in oxido-reduction status, biochemical and histopathological parameters were analyzed in heart tissue. DOX increased superoxide dismutase (SOD) and catalase activities to 3.4 ± 0.5 and 3.68 ± 1 from their normal values 2.43 ± 0.8 and 2.72 ± 0.88, respectively. The increased activities of both the enzymes were found reduced to 3.12 ± 0.24 and 3.41 ± 0.65 by the treatment of the extract. Similarly, DOX elevated glutathione peroxidase (GPx) activity to 44.6 ± 3.71 from the normal level 32.33 ± 3.41. DOX decreased the glutathione (GSH) level to 15.66 ± 2.51 from the normal values 31.66 ± 4.05. Upon treatment, GPx activity and GHS level found restored. The increased lipid peroxidation 2.53 ± 0.25 of DOX was also decreased to 2.0 ± 0.34 by the extract. Histopathology observations substantiate the protective effect of J. gendarussa extract. In conclusion, DOX-induced disturbance of oxido-reduction status and histopathology of heart attenuated closer to the normal indicating the protective effect of J. gendarussa against DOX-induced toxicity in cardiomyocytes.

July 20, 2023

Lung ultrasound-guided PEEP titration in COVID–19 patients treated with CPAP

Giorgio Bosso, Gennaro Sansone, Martina Papillo, Alessandro Giaquinto, Silvia Orefice, Enrico Allegorico, Claudia Serra, Valentina Minerva, Valentina Mercurio, Francesca Cannavacciuolo, Ferdinando Dello Vicario, Giovanni Porta, Antonio Pagano, Fabio Giuliano Numis

Page range: 677-682

Abstract

Objectives An increasing number of COVID–19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 patients requiring CPAP. Methods This is a single center, prospective, randomized clinical study. Sixty-three COVID-19 patients with hypoxemic respiratory failure and bilateral pneumonia were randomized in two Groups: Group A received CPAP with fixed PEEP of 10 cm H 2 O, Group B performed the “PEEP trial”, that consists in the evaluation of best PEEP defined as the PEEP value that precedes the echographic appearance of “lung pulse” determining a PaO 2 /FiO 2 increase. Primary outcome was composite in-hospital mortality + intubation, secondary outcome was the percentage increase of PaO 2 /FiO 2 . As safety indicator, the incidence of pneumothorax was collected. Results Thirty-two patients were enrolled in Group A and 31 in Group B . The two groups were comparable for clinical characteristics and laboratory parameters. The primary outcome occurred in 36 (57.1 %) patients: 23 (71.8 %) in Group A and 13 (41.9 %) in Group B (p<0.01). Mortality was higher in Group A (53.1 vs. 19.3 %, p<0.01), while intubation rate was comparable between groups. Group B showed a higher PaO 2 /FiO 2 increase than Group A (34.9 vs. 13.1 %, p<0.01). Five cases of pneumothorax were reported in Group A , none in Group B . Conclusions Lung ultrasound-guided PEEP trial is associated with lower mortality in COVID-19 patients treated with CPAP. Identifying the best PEEP is useful to increase oxygenation and reduce the incidence of complications.

Short Communication

December 2, 2022

Effects of the gaseous signalling molecule nitroxyl (HNO) on myenteric neurons governing intestinal motility

Ervice Pouokam

Page range: 683-687

Abstract

Objectives The main function of myenteric neurons is the control of gut motility. As we recently showed that nitroxyl (HNO) induces intestinal smooth muscle relaxation, it was of interest to evaluate the effects of this signalling molecule on myenteric neurons in order to distinguish its properties in regard to myocytes. Methods Myenteric neurons isolated from the ileum of 4–10 days old rats were used. HNO-induced changes in intracellular concentration of Ca 2+ or membrane potential and ion currents were measured using the Ca 2+ -sensitive fluorescent dye fura-2 AM or by electrophysiological whole-cell recordings, respectively. Changes in intracellular thiol groups pool were evaluated using thiol tracker violet. Angeli’s salt was used as HNO donor. Results The HNO donor Angeli’s salt induced a significant increase in the cytosolic Ca 2+ concentration at the concentration 50 µM and a membrane hyperpolarization from a resting membrane potential of −56.1 ± 8.0 mV to −63.1 ± 8.7 mV (n=7). Although potassium channels primarily drive membrane potential changes in these cells, outwardly rectifying potassium currents were not significantly affected by 50 µM Angeli’s salt. Fast inward sodium currents were slightly but not significantly reduced by HNO. In more sensitive cells, HNO tended to reduce the pool of thiol groups. Conclusions As in the case of smooth muscle cells, HNO causes hyperpolarization of myenteric neurons, an effect also associated with an increase in intracellular Ca 2+ concentration. Pathways other than activation of potassium currents appear to drive the hyperpolarization evoked by HNO.

Ahead of Print / Just Accepted

Ahead of Print / Just Accepted

Volume 34 (2023)

Volume 33 (2022)

Volume 32 (2021)

Volume 31 (2020)

Volume 30 (2019)

Volume 29 (2018)

Volume 28 (2017)

Volume 27 (2016)

Volume 26 (2015)

Volume 25 (2014)

Volume 24 (2013)

Volume 23 (2012)

Volume 22 (2011)

Volume 21 (2010)

Volume 20 (2009)

Volume 19 (2008)

Volume 18 (2007)

Volume 17 (2006)

Volume 16 (2005)

Volume 15 (2004)

Volume 14 (2003)

Volume 13 (2002)

Volume 12 (2001)

Volume 11 (2000)

Volume 10 (1999)

Volume 9 (1998)

Volume 8 (1997)

Volume 7 (1996)

Volume 6 (1995)

Volume 5 (1994)

Volume 4 (1993)

Volume 3 (1992)

Volume 2-3 (1992)

Issue Supplement

Volume 2 (1991)

Volume 1 (1990)

Issue 1-4

CiteScore	3.6	2022, Scopus (Elsevier B.V., 2023)
SCImago Journal Rank	0.365	2022, SJR (Scimago Lab, 2023; Data Source: Scopus)
Source Normalized Impact per Paper	0.617	2022, CWTS Journal Indicators (CWTS B.V., 2023; Data Source: Scopus)

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Editorial

Editor-in-Chief:
Ugo Oliviero (Federico II University, Naples, Italy)

Deputy Editor:
Alberto M. Marra (Federico II University, Naples, Italy and University of Heidelberg, Germany)

Associate/Section Editors:

Emergency Medicine: Giorgio Bosso (S. Maria delle Grazie Hospital, Pozzuoli, Naples)

Oncology: Evelyne Bischof (prev.Ewelina Biskup; University Hospital Basel, Switzerland, Shanghai University of Medicine & Health Sciences, Shanghai, China)

Hematology and Coagulation disorders: Pablo Demelo-Rodriguez (G. Marangon Hospital and Universidad Complutense de Madrid, Spain)

Vascular Medicine: Antonio Valvano (Legnano Hospital, Legnano, Italy)

Gastroenterology: Theodor Voiosu (University of Bucharest, Bucarest, Romenia)

Liver Disease: Andrei Voiosu (University of Bucharest, Bucarest, Romenia)

Neurology and Cerebrovascular: Lorenzo Falsetti (Azienda Ospedaliero-Universitaria "Ospedali Riuniti" di Ancona, Italy)

Gender Medicine: Valeria Raparelli (University of Ferrara, Ferrara, Italy)

Endocrinology: Ieva Ruza, (University of Riga, Riga, Latvia)

Diabetology and Metabolism: Mariarosaria De Luca (Federico II University, Naples)

Cardiovascular Diseases: Andrea Salzano (Glenfield General Hospital, University of Leicester, Leicester, UK)

Heart Failure: Antonio Cittadini (Federico II University of Naples, Naples, Italy)

Respiratory Medicine: Salvatore Torrisi (University of Catania, Catania, Italy)

Geriatrics: Leonardo Bencivenga (Federico II University, Naples, Italy)

Immunology: Gilda Varricchi (Federico II University, Naples, Italy)

Rheumatology: Domenico Sambataro (Artroreuma, Catania, Italy)

Basic Science: Francesca Vinchi (New York Blood Center, New York, USA), Roberta D’Assante (Federico II, Naples),

Urology, Andrology and Nephrology: Felice Crocetto (Federico II University, Naples, Italy)

Sport Medicine: Stefano Palermi (Federico II University, Naples)

Editorial Office:
E-mail: jbcpp.editorial@degruyter.com

(Deutsch)

Online ISSN: 2191-0286
Print ISSN: 0792-6855
Type: Journal
Language: English
Publisher: De Gruyter
First published: December 1, 1986
Publication Frequency: 6 Issues per Year
Audience: researchers and health professionals in the field of clinical physiology and pharmacology