The “messianic secret” in the New Testament refers to instances where Christ instructed his followers to keep silent about his identity. While contemporary studies on the messianic secret have predominantly employed the historico-critical method, the Early Modern Period witnessed diverse interpretations that focused on edification and moralization. These interpretations emphasized the concealed Messiah’s identity, the act of revelation, and the duty to transmit the divine message as inseparable aspects of the Christian faith. The primary objective of this study is to explore the development of messianic secret interpretations in the first half of the sixteenth century. The study aims to address key questions such as: How were Jesus’s injunctions to silence interpreted? How did these interpretations shape biblical readings, preaching practices, and the evangelical mission? Did they impact the definition of the Church? Through a comparative analysis, this study examines the interpretations of three relatively contemporary authors – Gabriele Biondo, Otto Brunfels, and Celio Secondo Curione. It argues for the interconnectedness between biblical exegesis, preaching, the audience, theological concepts like predestination, holy remnant, and salvation, as well as the organization of the Church. Ultimately, this research demonstrates that diverse interpretations of Jesus’s actions and the messianic secret were rooted in changes in exegetical methods, the definition of the Church, and the understanding of the salvific message conveyed by Christ.