journal: Journal of Pediatric Endocrinology and Metabolism

Impact Factor: 1.4

Published since January 1, 1985

Journal of Pediatric Endocrinology and Metabolism

ISSN: 2191-0251

Editor-in-chief: Wieland Kiess

Edited by: Abdullah Bereket, Mehul Dattani, Justin Davies, Jan Gustafsson, Fei Hong Luo, Roderick Mitchell, Burcu Öztürk-Hişmi, Raja Padidela, Jorma Toppari, Serap Demircioglu Turan

Submit manuscript

About this journal

Objective
The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers). JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.

Topics

Pediatric endocrinology
Pediatric diabetes
Inherited metabolic diseases

Article formats

Original Research, Reviews, Mini Reviews, Opinion Papers, Case Report, Short Communications, Letters to the Editor (including comments on published papers)

Your Benefits

Your Benefits

Up-to-date research on pediatric endocrinology and metabolism
Clinical investigations and basic research from all over the world
Worldwide-known editors and reviewers
Rapid online publication of contributions “ahead-of-print”

History

Published at De Gruyter since 2011

Other publications in the field

Journal of Perinatal Medicine

Case Reports in Perinatal Medicine (Open Access)

Journal of Transition Medicine (Open Access)

International Journal of Adolescent Medicine and Health

Clinical Chemistry and Laboratory Medicine

Diagnosis

Abstracting and Indexing

Journal of Pediatric Endocrinology and Metabolism is covered by the following services:

Baidu Scholar
Cabells Journalytics
CABI (over 50 subsections)
Chemical Abstracts Service (CAS) - CAplus
Chemical Abstracts Service (CAS) - SciFinder
CNKI Scholar (China National Knowledge Infrastructure)
CNPIEC - cnpLINKer
Dimensions
EBSCO (relevant databases)
EBSCO Discovery Service
EMBASE
Genamics JournalSeek
Google Scholar
ICAP Alcohol Information Databases
Index Copernicus
Japan Science and Technology Agency (JST)
J-Gate
Journal Citation Reports/Science Edition
JournalGuide
JournalTOCs
KESLI-NDSL (Korean National Discovery for Science Leaders)
Medline
MyScienceWork
Naver Academic
Naviga (Softweco)
Pathway Studio
Primo Central (ExLibris)
ProQuest (relevant databases)
Publons
PubMed
PubsHub
QOAM (Quality Open Access Market)
ReadCube
Reaxys
Scilit
SCImago (SJR)
SCOPUS
Semantic Scholar
Sherpa/RoMEO
Summon (ProQuest)
TDNet
Text Mining
Ulrich's Periodicals Directory/ulrichsweb
WanFang Data
Web of Science - Biological Abstracts
Web of Science - BIOSIS Previews
Web of Science - Current Contents/Life Sciences
Web of Science - Prous Science Integrity
Web of Science - Science Citation Index
Web of Science - Science Citation Index Expanded
WorldCat (OCLC)
X-MOL
Yewno Discover

Supplementary Materials

Topics

External Links

Volume 36 Issue 12

December 2023

Publicly Available November 29, 2023

Frontmatter

Page range: i-iii

Download PDF

Review

October 30, 2023

Intracranial germ cell tumors: a view of the endocrinologist

Tao Tong, Li-Yong Zhong

Page range: 1115-1127

Abstract

Intracranial germ cell tumors (iGCTs) are rare malignant neoplasms that mainly affect children and adolescents. The incidence, clinical presentation, and prognosis of iGCTs exhibit high heterogeneity. Previous studies have primarily focused on eliminating tumors, reducing tumor recurrence, and improving survival rates, while neglecting the impact of the tumors and their treatment on neuroendocrine function. Throughout the entire course of the disease, neuroendocrine dysfunction may occur and is frequently overlooked by oncologists, neurosurgeons, and radiologists. Endocrinologists, however, are more interested in this issue and have varying priorities at different stages of the disease. From onset to the diagnostic phase, most patients with iGCTs may present with symptoms related to impaired neuroendocrine function, or even experience these symptoms as their first indication of the condition. Particularly, a minority of patients with sellar/suprasellar lesions may exhibit typical imaging features and elevated tumor markers long after the onset of initial symptoms. This can further complicate the diagnosis process. During the peritumor treatment phase, the neuroendocrine function shows dynamic changes and needs to be evaluated dynamically. Once diabetes insipidus and dysfunction of the hypothalamic–pituitary–adrenal and hypothalamic–pituitary–thyroid axes occur, hormone replacement therapy should be administered promptly to ensure successful tumor treatment for the patient. Subsequently, during the long-term management phase after the completion of tumor treatment, the evaluation of growth and development as well as corresponding hormone replacement therapy are the most concerning and complex issues. Thus, this paper reviews the interest of endocrinologists in iGCTs at different stages.

Original Articles

Open Access October 19, 2023

Technology use and clinical outcomes in a racial-ethnic minority cohort of children and adolescents with type 1 diabetes

Daniela Baboun, Natalia Solano, Victoria Del Toro, Rose Alvarez-Salvat, Andrea Granados, Adriana Carrillo-Iregui

Page range: 1128-1132

More Download PDF

Abstract

Objectives Technology use has been shown to improve diabetes control, but minority youths tend to have low rates of technology use and exhibit suboptimal glycemic control. We examined the impact of continuous glucose monitors (CGM) and continuous subcutaneous insulin infusion (CSII) on glycemic control in a racial-ethnic minority cohort of children and adolescents with type 1 diabetes (T1D). Methods A cross-sectional study was conducted among 140 pediatric T1D patients seen at a multidisciplinary clinic. From January to November 2022, data on demographics and glycated hemoglobin (HbA 1c ) levels were collected. Patients were categorized as technology (CGM, CSII, or both) or non-technology users (finger stick meter (FS) and multiple daily injections (MDI)). Results The majority identified as Hispanic (79 %) and had public health insurance (71 %). Sixty-nine percent used technology. Compared with non-technology users, technology users had significantly lower mean HbA 1c levels (9.60 vs. 8.40 %, respectively) (p=0.0024), though no group (CGM + CSII, CGM + MDI, FS + CSII, and FS + MDI) achieved a mean HbA 1c level of <7.0 %. Regarding minority status, no significant differences in mean HbA 1c levels existed between Hispanics and Blacks in the CGM + MDI and FS + CSII groups (p=0.2232 and p=0.9224, respectively). However, there was a significant difference in mean HbA 1c levels between Hispanic and Black non-technology users (9.19 vs. 11.26 %, respectively) (p=0.0385). Conclusions Technology users demonstrated better glycemic control than non-technology users. Further research is needed to investigate factors affecting glycemic control in minority youths with T1D.

Open Access November 22, 2023

The use of CGM to identify hypoglycemia and glycemic patterns in congenital hyperinsulinism

Martin Gariepy, Niyoosha Yoosefi, Carolina Silva, Jean-Pierre Chanoine, Fatema S. Abdulhussein

Page range: 1133-1139

More Download PDF

Abstract

Objectives Unrecognized hypoglycemia, especially in the neonatal population, is a significant cause of morbidity and poor neurologic outcomes. Children with congenital hyperinsulinism (HI) are at risk of hypoglycemia and point of care testing (POCT) is the standard of care. Studies have shown that continuous glucose monitoring (CGM) improves glycemic control and reduces the frequency of hypoglycemia among children with type 1 diabetes. There is limited experience with the use of CGM in children with HI. To assess the glycemic pattern of children with HI on stable therapy and evaluate the frequency of undetected hypoglycemia using Dexcom G6 ® CGM. Methods A cross-sectional, observational pilot study was done in 10 children, ages 3 months to 17 years. Each child had a clinical or genetic diagnosis of HI on stable medical therapy. Participants were asked to continue their usual POCT blood glucose monitoring, as well as wear a blinded Dexcom G6 ® CGM during a 20-day study period with the potential of unblinding if there was severe hypoglycemia detected during the study trial. Results During the study period, 26 hypoglycemic events were noted by CGM in 60 % of the participants with 45 % occurring between 0600 and 0800. Conclusions CGM can help detect hypoglycemia and blood glucose trends during a time when there is usually no POCT, which can guide medical management. 30 % of our population had a dose adjustment in their medications. This study was limited by population size.

October 26, 2023

The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile

Blanca Guijo, Jesús Argente, Gabriel Ángel Martos-Moreno

Page range: 1140-1145

Abstract

Objectives To study the prevalence and influence on metabolic profile of the prohormone-convertase-1 (PCSK1) N221D variant in childhood obesity, proven its role in the leptin-melanocortin signaling pathway as in proinsulin and other prohormone cleavage. Methods Transversal study of 1066 children with obesity (mean age and BMI Z-score 10.38 ± 3.44 years and +4.38 ± 1.77, respectively), 51.4 % males, 54.4 % prepubertal, 71.5 % Caucasians and 20.8 % Latinos. Anthropometric and metabolic features were compared between patients carrying the N221D variant in PCSK1 and patients with no variants found after next generation sequencing analysis of 17 genes ( CREBBP, CPE, HTR2C, KSR2, LEP, LEPR, MAGEL2, MC3R, MC4R, MRAP2, NCOA1, PCSK1, POMC, SH2B1, SIM1, TBX3 and TUB ) involved in the leptin-melanocortin pathway. Results No variants were found in 531 patients (49.8 %), while 68 patients carried the PCSK1 N221D variant (42 isolately, and 26 with at least one additional gene variant). Its prevalence was higher in Caucasians vs. Latinos (χ 2 7.81; p<0.01). Patients carrying exclusively the PCSK1 N221D variant (n=42) showed lower insulinemia (p<0.05), HOMA index (p<0.05) and area under the curve for insulin in the oral glucose tolerance test (p<0.001) and higher WBISI (p<0.05) than patients with no variants, despite similar obesity severity, age, sex and ethnic distribution. Conclusions The N221D variant in PCSK1 is highly prevalent in childhood obesity, influenced by ethnicity. Indirect estimation of insulin resistance, based on insulinemia could be byassed in these patients and underestimate their type 2 diabetes mellitus risk.

October 6, 2023

Evaluation of the risk factors for noncommunicable diseases in patients with inborn errors of amino acid metabolism receiving nutrition therapy

Mehmet Cihan Balci, Meryem Karaca, Alihan Yesil, Arzu Selamioglu, Huseyin Kutay Korbeyli, Asli Durmus, Belkis Ak, Tugba Kozanoglu, Ilknur Hacioglu, Gulden Fatma Gokcay

Page range: 1146-1153

Abstract

Objectives There is growing concern about the low-protein and high-energy diet therapies used in the treatment of inherited amino acid metabolism disorders. We aimed to identify the risk factors for noncommunicable diseases that may arise from nutritional therapies and suggests approaches that may prevent the development of the noncommunicable diseases. Methods The present study evaluates 112 patients, on long-term nutritional therapy for at least the last 2 years with a diagnosis of an inborn error of the amino acid metabolism, and their 28 healthy siblings. The participants are assessed for the development of overweight and metabolic syndrome based on an analysis of anthropometric parameters, body composition and the results of biochemical tests. Results Anthropometric measurements including BMI, weight Z-score, waist circumference and fat mass were not significantly different between patients and controls. Height Z-scores were similar in phenylketonuria patients compared to controls, but lower in urea cycle disorders, organic acidemia and maple syrup urine disease groups. No increased risk of development of overweight or metabolic syndrome was detected in the patient group, while there were findings suggesting malnutrition in patients diagnosed with urea cycle disorders. There was a correlation between patients’ BMI and C3-carnitine levels in organic acidemia patients and leucine levels in maple syrup urine disease patients. Conclusions All forms of malnutrition can be prevented in patient groups receiving limited nutrients under a dietary management protocol, based on the findings of anthropometric and biochemical evaluations and analyses of body composition.

November 10, 2023

Features of liver injury in 138 Chinese patients with NICCD

MinYan Jiang, MinZhi Peng, ZhiKun Lu, YongXian Shao, ZongCai Liu, XiuZhen Li, YunTing Lin, Li Liu, Wen Zhang, YanNa Cai

Page range: 1154-1160

Abstract

Objectives To find biochemical and molecular markers can assist in identifying serious liver damage of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) patients. Methods 138 patients under 13 days to 1.1 year old diagnosed of NICCD in our center from 2004 to 2020. Base on the abnormal liver laboratory tests, we divided 138 patients into three groups: acute liver failure (ALF), liver dysfunction, and non-liver dysfunction groups, then compared their clinical, biochemical and, molecular data. Results 96 % of 138 patients had high levels of citrulline and high ratio of threonine to serine, which is the distinctive feature of plasma amino acid profile for NICCD. A total of 18.1 % of 138 patients had evidence of ALF who presented the most severity hepatic damage, 51.5 % had liver dysfunction, and the remaining 30.4 % presented mild clinical symptoms (non-liver dysfunction). In ALF group, the levels of citrulline, tyrosine, TBIL, ALP, and γ-GT was significantly elevated, and the level of ALB and Fisher ratio was pronounced low. Homozygous mutations of 1,638_1660dup, IVS6+5G.A, or IVS16ins3kb in SLC25A13 gene were only found in ALF and liver dysfunction groups. Supportive treatment including medium-chain triglyceride supplemented diet and fresh frozen plasma could be life-saving and might reverse ALF. Conclusions High level of citrulline, tyrosine, TBIL, ALP, γ-GT, and ammonia, low level of albumin, and low Fisher ratio were predictors to suggest severe liver damage in NICCD patients who may go on to develop fatal metabolic disorder. Early identification and proper therapy is particularly important for these patients.

October 20, 2023

A case-control study of early-stage radiological markers of endothelial dysfunction and cardiovascular findings in patients with osteogenesis imperfecta: genotype–phenotype correlations

Ferda Evin, Derya Aydın, Ertürk Levent, Samim Özen, Şükran Darcan, Damla Gökşen

Page range: 1161-1168

Abstract

Objectives Osteogenesis imperfecta (OI) is a disease caused by defective collagen synthesis. Collagen type 1 is found in many structures in the cardiovascular system. Endothelial dysfunction, which develops prior to the emergence of structural and clinical signs of atherosclerosis, is believed to play a key role in atherogenesis. Endothelial dysfunction may be detected presymptomatically by non-invasive radiologic methods, such as flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT). These modalities may provide early indicators of endothelial dysfunction. This cross-sectional comparative study aimed to investigate early-stage radiological markers of endothelial dysfunction and cardiovascular diseases in OI patients and healthy controls and to investigate the correlation of findings with OI genotype. Methods Thirty patients diagnosed with OI were paired with thirty healthy age- and gender-matched controls and echocardiogram findings were compared. Results None of the patients had known underlying cardiovascular disease. The mean age was 13.18 ± 2.91 years. According to Sillence classification, 15 patients had type 1 OI, 10 had type III, and 5 had type IV. Mean CIMT in the OI group was higher in the control group (OI group: 0.42 ± 0.06 vs. healthy controls: 0.34 ± 0.04 mm, p<0.01), and mean FMD percent was lower in the patient group (p<0.01). Left ventricular ejection fraction was 78.97 ± 10.32 vs. 77.56 ± 8.50 %, (OI group: 7.00 ± 3.06 vs. healthy controls: 12.14 ± 1.99, p=0.56), and fractional shortening was 42.68 ± 11.94 vs. 40.23 ± 7.99 %, (p=0.35), in OI patients and controls, respectively. Conclusions Pediatric patients with OI without clinical signs of cardiovascular abnormality had significantly worse CIMT and FMD findings than healthy controls. However, no difference was determined when comparing left ventricular ejection fraction or fractional shortening. OI patients may need to be screened for cardiovascular system complications starting from an early age.

October 30, 2023

Caregivers’ knowledge and medication adherence in children with thyroid disorders: an exploratory study

Neetu Gujjar, Poonam Verma, Latika Rohilla, Shivalli Sirswal, Divya Sharma, Devi Dayal

Page range: 1169-1174

Abstract

Objectives Many thyroid disorders in children demand long-term therapy. The parent’s understanding of the child’s condition is of utmost importance for adherence to treatment. The study objective was to assess the knowledge, medication adherence, reasons for non-adherence, and their relationship with various clinical parameters. Methods An exploratory, cross-sectional study with a total enumeration sampling technique was conducted between July 2022 and September 2022. Children and young adults aged ≤18 years who were diagnosed with a thyroid disorder and taking medications for at least 3 months were included. Data were collected by interviewing parents using the Adherence to Refills and Medications Scale (ARMS) and structured knowledge questionnaire. Results Parents of 102 children were interviewed. The mean age of the children was 9.2 ± 0.4 years; 58 (57 %) were girls. The mean duration of treatment was 5.5 ± 0.3 years. Many (66 %) informants were mothers. Three-fourths (75.5 %) of parents were educated up to senior secondary and above. Most (91.2 %) of parents had poor knowledge about the disease and its management. Poor disease knowledge was significantly linked to lower education (p<0.001). Nonetheless, strong adherence (>80 %) was noted on the ARMS scale. No significant correlation was found between physical growth, thyroid function, and adherence/knowledge (p-values 0.20–0.71). Conclusions The caregivers’ knowledge of thyroid disorders was poor and related to their educational level. There is a need to use clear language and ensure that parents have an adequate understanding of their child’s condition. Healthcare professionals should assess and address gaps in parental knowledge and adherence.

November 3, 2023

Implementation of IT supported standardization of individualized hydrocortisone management for treatment of patients with adrenal insufficiency

Varshini Chakravarthy, Katie Barger, Rob Gonsalves, Gabriel Q. Shaibi, Vinay Vaidya, Chirag Kapadia, Dorothee Newbern

Page range: 1175-1180

Abstract

Objectives Hydrocortisone stress dosing guidelines for children with adrenal insufficiency (AI) recommend a wide range of acceptable stress doses. This has led to variability in dosing recommendations resulting in confusion among endocrine, non-endocrine providers and patient families. This quality improvement project sought to standardize documentation and hydrocortisone stress dosing within our pediatric endocrine division to optimize communication regarding AI management. Methods Plan-Do-Study-Act (PDSA) cycle one aimed to address documentation of components important in AI management including body surface area (BSA), home daily dose, home stress dose, in-patient stress dose, procedure dose and crisis dose using a smart phrase within the electronic health record (EHR). To automate the process, PDSA cycle two introduced two smart buttons within the endocrine notes. PDSA cycle three focused on standardizing hydrocortisone stress doses. Results Initial documentation targets were met for all AI management components except for the crisis dose. The second target was only met for the home stress dose. Implementing the smart buttons aided in reaching the second target for home daily and home stress doses. Dose standardization targets were achieved in all categories except for the on-going crisis dose. A follow up survey after an in-service for non-endocrine providers showed increased knowledge of locating hydrocortisone stress dosing recommendations within the EHR. Conclusions With the assistance of technology, this quality improvement project ultimately enhanced communication through the standardization of documentation and individualized hydrocortisone stress dosing for children with AI. Although not all secondary targets were met, there was meaningful improvement in documentation and stress dose standardization compliance.

October 18, 2023

Interdisiplinary and intraobserver reliability of the Greulich-Pyle method among Turkish children

Kerim Sariyilmaz, Saygin Abali, Nezih Ziroglu, Tunca Cingoz, Okan Ozkunt, Zehra Yavaş Abali, Cem Burak Kalayci, Merve Hayretci, Serap Semiz

Page range: 1181-1185

Abstract

Objectives Greulich-Pyle (GP) is one of the most used method for bone age determination (BAD) in various orthopedic, pediatric, radiological, and forensic situations. We aimed to investigate the inter- and intra-observer reliability of the GP method between the most relevant disciplines and its applicability to the Turkish population. Methods One-hundred and eighty (90 boys, 90 girls) patients with a chronological age younger than 18 (mean 9.33) were included. X-rays mixed by the blinded investigator were evaluated by two orthopedists, two radiologists, and two pediatric endocrinologists to determine skeletal age according to the GP atlas. A month later the process was repeated. As a statistical method, Paired t-test was used for comparison, an Intraclass Correlation Coefficients test was used for reliability and a 95 % confidence interval was determined. Results were classified according to Landis-Koch. Results All results were consistent with chronological age (p<0.001), according to the investigators’ evaluations compared with chronological age. At the initial evaluation, the interobserver reliability of the method was 0.999 (excellent); at the second evaluation, the interobserver reliability was 0.997 (excellent). The intra-observer reliability of the method was ‘excellent’ in all observers. When results were separately evaluated by gender, excellent intraobserver correlation and excellent correlation with chronological age were found among all researchers (>0.9). When X-rays were divided into three groups based on age ranges and evaluated, ‘moderate’ and ‘good’ correlations with chronological age were obtained during the peripubertal period. Conclusions The GP method used in skeletal age determination has excellent inter- and intra-observer reliability. During the peripubertal period, potential discrepancies in bone age assessments should be kept in mind. This method can be used safely and reproducibly by the relevant specialists.

Case Report

November 20, 2023

Alpha-mannosidosis: a case with novel ultrastructural and light microscopy findings

Matthew Leong, Bindu Sathi, Amy Davis, Syed Hamid, Sandy Wu, Jeremy Woods, Sandhya Kharbanda, Xiaomo Li, Jean Hou

Page range: 1186-1190

Abstract

Objectives Alpha-mannosidosis is a rare genetic lysosomal storage condition leading to the systemic buildup of oligomannoside. Clinical presentation and associated conditions, as well as the full extent of histopathologic changes associated with this disease process, are not fully understood. Case presentation We present the case of an 8-year-1-month old patient with persistent anemia and who was initially diagnosed with Celiac disease before ultimately being diagnosed with alpha-mannosidosis. As part of his diagnostic work-up, duodenal and bone marrow biopsies were examined by pathology. Duodenal biopsies showed foamy plasma cells expanding the lamina propria which triggered a workup for a genetic storage disease; features suggestive of Celiac disease which resolved on gluten-free diet were also noted by pathology. Bone marrow analysis via electron microscopy showed cytoplasmic granules and inclusions in multiple immune cell lines. Conclusions Alpha-mannosidosis can occur with Celiac disease and milder forms may only be suspected from incidental pathology findings. The ultrastructural bone marrow findings from this case, the first to be reported from human, show numerous disease-associated changes in multiple immune cell lines whose contribution to disease-associated immunodeficiency is unclear.

Letters to the Editor

October 25, 2023

Reply to: The relationship between estrogen and subsequent growth restriction among adolescents with heavy menstrual bleeding at menarche

Emrullah Arslan, Samim Ozen

Page range: 1191-1192

Open Access October 25, 2023

In reply re: The relationship between estrogen and subsequent growth restriction among adolescents with heavy menstrual bleeding at menarche

Jessie M. Nelson, Sarah D. Compton, Mina M. Farahzad, Olivia K. Winfrey, Monica W. Rosen

Page range: 1193-1194

Download PDF

Ahead of Print / Just Accepted

Ahead of Print / Just Accepted

Volume 36 (2023)

Volume 35 (2022)

Volume 34 (2021)

Volume 33 (2020)

Volume 32 (2019)

Volume 31 (2018)

Volume 30 (2017)

Volume 29 (2016)

Volume 28 (2015)

Volume 27 (2014)

Volume 26 (2013)

Volume 25 (2012)

Volume 24 (2011)

Volume 23 (2010)

Volume 22 (2009)

Volume 21 (2008)

Volume 20 (2007)

Volume 19 (2006)

Volume 18 (2005)

Volume 17 (2004)

Volume 16 (2003)

Volume 15 (2002)

Volume 14 (2001)

Volume 13 (2000)

Volume 12 (1999)

Volume 11 (1998)

Volume 10 (1997)

Volume 9 (1996)

Volume 8 (1995)

Volume 7 (1994)

Volume 6 (1993)

Volume 5 (1992)

Volume 4 (1991)

Volume 3 (1989)

Volume 2 (1987)

Volume 1 (1985)

Journal Impact Factor	1.4	2022, Journal Citation Reports (Clarivate, 2023)
5-year Journal Impact Factor	1.5	2022, Journal Citation Reports (Clarivate, 2023)
Journal Citation Indicator	0.45	2022, Journal Citation Reports (Clarivate, 2023)
CiteScore	2.4	2022, Scopus (Elsevier B.V., 2023)
SCImago Journal Rank	0.430	2022, SJR (Scimago Lab, 2023; Data Source: Scopus)
Source Normalized Impact per Paper	0.624	2022, CWTS Journal Indicators (CWTS B.V., 2023; Data Source: Scopus)

More information about journal rankings

Submit

Submission
You can easily submit your manuscript online. Simply go to http://mc.manuscriptcentral.com/jpem and you will be guided through the whole peer reviewing and submission process.

Your benefits of publishing with us

Rapid publication times
No submission fee
Free publication of color figures both in online and print editions and no page charges
Optional open access publication
Accepted papers will be published online first as DOI-citable, forward-linked articles for quickest possible visibility for the scientific community
Every article easily discoverable because of Search Engine Optimization (SEO) and comprehensive abstracting and indexing services
Secure archiving by De Gruyter and the independent archiving service Portico
Professional sales and marketing activities

Submission process

Submit your paper via our Scholar One submission management tool following the Information for Authors. After logging in you will be guided through every step of the submission process
Single-blind peer review process
A decision on your paper is aspired within 2-4 weeks
Accepted articles are published online ahead of print approx. 4 weeks after acceptance

Please note

Manuscripts must be written in clear and concise English
Before submitting your article please have a look at our Ethical Guidelines and our Licence to Publish
The Ethics Statements for our journal are based on the Committee on Publication Ethics (COPE) Best Practice Guidelines for Journal Editors
For every submission, authors have to fill out and upload the Template for Ethical and Legal Declarations at the time of the original submission. Instructions on how to make declarations can be found here
Once your article is accepted you have the option to publish it open access
Our Repository Policy allows you to distribute 30 PDF copies of your published article to colleagues (the PDF has to include the information that it is an author's copy). Please also feel free to distribute the link to the online abstract
If you have any general questions please visit our FAQ page for authors
For more detailed information please contact the JPEM Editorial Office at jpem.editorial@degruyter.com

We look forward to receiving your manuscript!

Hybrid Open Access

In this journal, authors have the option to publish their article under an open access license. Open Access allows you as an author to retain copyright and share your findings with colleagues and interested parties worldwide without any restraints.
Please note that authors from institutions with which we have a transformative agreement can publish open access without paying an article processing charge (APC). More information on the eligible institutions and articles can be found under the "Funding and Support" tab here.

Editorial

Editor-in-Chief
Wieland Kiess, Leipzig, Germany

Founding Editor
Harry J. Hirsch, Jerusalem, Israel

Honorary Editors
Zvi Laron, Petah Tikva, Israel
Zvi Zadik, Rehovot, Israel

Managing Editor
Anna Kirstein, Leipzig, Germany

Associate Editors
Abdullah Bereket, Istanbul, Turkey
Mehul Dattani, London, United Kingdom
Justin Davies, Southampton, United Kingdom
Jan Gustafsson, Uppsala, Sweden
Sasha Howard, London, United Kingdom
Feihong Luo, Shanghai, China
Raja Padidela, Manchester, United Kingdom
Burcu Öztürk-Hişmi, Istanbul, Turkey
Jorma Toppari, Turku, Finland
Serap Turan, Istanbul, Turkey

Editorial Board
Tadej Battelino, Ljubljana, Slovenia
Fernando Cassorla, Santiago de Chile, Chile
George Chrousos, Athens, Greece
Wayne Cutfield, Auckland, New Zealand
Johnny Deladoey, Montreal, QC, Canada
Rasha Tarif Hamza, Cairo, Egypt
Eli Hershkovitz, Beersheba, Israel
Stephen LaFranchi, Portland, OR, USA
Roberto Lanes, Caracas, Venezuela
Warren Lee, Singapore
Angelika Mohn, Chieti, Italy
Margaret Zacharin, Parkville, Australia

Editorial Office
Heike Jahnke
Walter de Gruyter GmbH
Genthiner Str. 13
10785 Berlin, Germany
E-mail: Heike.Jahnke@degruyter.com

(Deutsch)

Online ISSN: 2191-0251
Print ISSN: 0334-018X
Type: Journal
Language: English
Publisher: De Gruyter
First published: January 1, 1985
Publication Frequency: 12 Issues per Year
Audience: researchers and practitioners interested in pediatric endocrinology and metabolism