Impact Factor: 2.716

Published since January 1, 1973

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine, the International Academy of Perinatal Medicine, the New York Perinatal Society, and the Society for the Fetus as a Patient

ISSN: 1619-3997

Editor-in-chief: Joachim W. Dudenhausen, MD, FRCOG

Edited by: Thorsten Braun, Frank A. Chervenak, Vincenzo D'Addario, Marty Ellington, Mehmet R. Genc, Anne Greenough, Amos Grunebaum, Asim Kurjak, Roberto Romero, Daniel W. Skupski, Ivica Zalud

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About this journal

Journal of Perinatal Medicine: Happy 50th Anniversary
The Journal of Perinatal Medicine (JPM) is celebrating its 50th anniversary. The first issue was published in January 1973, making it the first scientific journal in the field of perinatal medicine. JPM was founded by Erich Saling of Berlin (Germany), the father of perinatal medicine, and Roberto Caldeyro Barcia of Uruguay, an expert in uterine contractility, Edward Hon from the USA, who pioneered electronic heart rate monitoring of the fetus, and Stanley James, one of the most outstanding neonatologists. Over the past 50 years, JPM has grown with the increasing number of annual submissions and readers, as well as increasing impact within the scientific community.
Enjoy reading the Special Anniversary Issue we published on the occasion of JPM's milestone birthday!

Objective
The Journal of Perinatal Medicine (JPM) is a truly international forum covering the entire field of perinatal medicine. It is an essential news source for all those obstetricians, neonatologists, perinatologists and allied health professionals who wish to keep abreast of progress in perinatal and related research. Ahead-of-print publishing ensures fastest possible knowledge transfer. The Journal provides statements on themes of topical interest as well as information and different views on controversial topics. It also at informs about the academic, organisational and political aims and objectives of the World Association of Perinatal Medicine (WAPM)

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Topics
JPM covers the entire field of perinatal medicine, obstetrics and neonatology. It is published in 9 issues per year.

Article formats
Research Articles, Reviews, Mini Reviews and Opinion Papers, Short Communications, Editorials, Letters to the Editor, WAPM-Newsletters

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New results from the clinical and experimental areas
Theoretical and practical aspects of all subdisciplines
Fast transfer of knowledge
Critical, high quality peer-review

Since 2014 the Journal of Perinatal Medicine has been the official journal of the International Academy of Perinatal Medicine and the New York Perinatal Society.

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Content available since 1973

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Volume 51 Issue 3

March 2023

Publicly Available March 14, 2023

Frontmatter

Page range: i-iv

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Editorial

Publicly Available February 28, 2023

A Celebration of Professor Joachim Dudenhausen

Roberto Romero, Heike Jahnke, Thorsten Braun, Frank Chervenak, Vincenzo D’Addario, Marty Ellington, Mehmet R. Genc, Anne Greenough, Amos Grunebaum, Asim Kurjak, Daniel W. Skupski, Ivica Zalud

Page range: 285-290

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Reviews

November 18, 2022

Gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021: systematic review of longitudinal studies

Gian Carlos Ramirez Ubillus, Eduardo Eulogio Sedano Gelvet, Carlos Ricardo Neira Montoya

Page range: 291-299

Abstract

Objectives To identify gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021. Content The risk of gestational complications was confirmed during SARS-CoV and MERS-CoV infection. However, this is not robust for COVID-19 because there is still no scientific evidence from longitudinal studies. A systematic review was performed using four databases, and 14 prospective or retrospective cohorts were finally included in the analysis. Summary The most frequently associated sociodemographic characteristic or comorbidity was the presence of any previous comorbidity (9 studies, 64.3%), followed by ethnicity and age (6 studies each one, 42.9%). The most frequently associated gestational complications in mothers were the admission to Intensive Care Unit (4 studies, 28.6%) and gestational age at delivery <37 weeks (3 studies, 21.4%). The most frequently associated gestational complications in newborns were preterm birth (4 studies, 28.6%) and the admission to Neonatal Intensive Care Unit (2 studies, 14.3%). Outlook Pregnant women infected with SARS-CoV-2 appear to have a higher risk of admission to Intensive Care Unit. Newborns of mothers infected with SARS-CoV-2 appear to have a higher risk of preterm birth and admission to Neonatal Intensive Care Unit.

August 24, 2022

Eclampsia a preventable tragedy: an African overview

Labaran Dayyabu Aliyu, Abubakar Saidu Kadas, Mohammed Abdulsalam, Hauwa Musa Abdulllahi, Zubaida Farouk, Fatima Usman, Raphael Avidime Attah, Murtala Yusuf, Mahmoud Kawu Magashi, Mustapha Miko

Page range: 300-304

Abstract

Eclampsia is a multisystemic disease associated with various complications which individually or in combination can lead to maternal/fetal morbidity and mortality. Developed countries and some developing countries were largely successful in reducing the incidence of eclampsia. Developing countries especially those in Sub-Saharan Africa (SSA) are still dealing with high incidence of eclampsia. The question is why have the incidence and mortality of eclampsia remained high in SSA? The risk factors for this disease are globally the same but a critical assessment showed that there are certain risk factors that are common in Sub-Saharan Africa (multiple pregnancy, sickle cell disease, pregnancies at the extremes of reproductive age, pre-existing vasculitis). In addition, there are compounding factors (illiteracy, poverty, superstitious beliefs, poor prenatal care services, poorly trained manpower and lack of facilities to cater for patients). Addressing the menace of this disease require a holistic approach which among others, includes education to address beliefs and reduce harmful practices, poverty alleviation which will improve the ability for communities to afford health care services. Improving transport services to convey patients quickly to facilities on time when there is need. Improving the health infrastructure, building more facilities, providing trained and motivated manpower and regular supply of quality essential drugs for the management of the disease. This review is meant to analyze factors prevalent in Sub-Saharan that hinder reducing incidence of the disease and provide comprehensive and cost-effective solutions.

Original Articles – Obstetrics

August 11, 2022

How do bicornuate uteri alter pregnancy, intra-partum and neonatal risks? A population based study of more than three million deliveries and more than 6000 bicornuate uteri

Einav Kadour Peero, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan

Page range: 305-310

Abstract

Objectives To explore maternal and neonatal outcomes in pregnant women with bicornuate uteri. Methods Retrospective population-based cohort study utilizing data from the Healthcare-Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) from 2010 to 2014. There were 3,846,342 births between 2010 and 2014, included in the study. Six thousand and 195 deliveries were to women with bicornuate uterus. The remaining deliveries without other uterine anomalies were categorized as the reference group (n=3,840,147). Results Pregnant women with bicornuate uterus were older and more likely to be obese (p=0.0001) with previous cesarean deliveries (CD) (31 vs. 17.1%, p=0.0001). After adjustment for confounders, they were more likely to experience pregnancy-induced hypertension (HTN) (aOR 1.21, 95%CI: 1.1–1.3), p=0.0001), preeclampsia (aOR 1.4, 95%CI: 1.2–1.6, p=0.0001) and placenta previa (aOR 1.7, 95%CI: 1.3–2.2, p=0.0001). Moreover, they were more likely to deliver preterm (aOR 2.8, 95%CI: 2.6–3.1, p=0.0001), deliver by CD (aOR 5, 95%CI: 3.1–4.1, p=0.0001), experience preterm pre-labor rupture of membranes (PPROM) (aOR 3.5, 95%CI: 2.6–3.1, p=0.0001), and have a placental abruption (aOR 3.0, 95%CI: 2.5–3.5, p=0.0001). There were increased risks of PPH (aOR 1.4, 95%CI: 1.2–1.6, p=0.0001), wound-complications (aOR 2.0, 95%CI: 1.5–2.7, p=0.0001), hysterectomy (aOR 2.6, 95%CI: 1.6–4.1, p=0.0001), blood-transfusion (aOR 1.7, 95%CI: 1.5–2.1, p=0.0001), and DIC (aOR 1.6, 95%CI: 1.1–2.5), p=0.014) in the group with bicornuate uteri. Also there was higher risk of SGA (aOR 2.9, 95%CI: 2.6–3.2, p=0.0001) and IUFD (aOR 2.5, 95%CI: 1.8–3.3, p=0.0001). Conclusions Bicornuate uteri can increase risks in pregnancy by many folds. Particularly risks of: premature delivery, CD, PPROM, placental abruption, hysterectomy, SGA and IUFD were increased 250–500%.

August 11, 2022

Maternal urogenital infection and fetal heart functional assessment – what is the missing link?

Julia Murlewska, Oskar Sylwestrzak, Iwona Strzelecka, Maria Respondek-Liberska

Page range: 311-316

Abstract

Objectives Maternal urogenital infections during pregnancy are worldwide frequent problem. The aim was to analyze influence of maternal genitourinary infection on fetal cardiac function, pregnancy development and obstetrical outcomes. Methods This was a single-center cohort study on fetuses (average at 28th week) in two groups: with maternal urogenital infections (study group n=49) and control group with no infections (n=59). Parvovirus B19, toxoplasmosis, cytomegalovirus, herpes simplex infections, congenital malformations, fetal growth restriction, chronic maternal diseases, as well as patients with body mass index (BMI) >25 kg/m2 were excluded. We analyzed: maternal age, time of delivery, neonatal birth weight, Apgar scores, average time of hospitalization of newborns after birth and several fetal echocardiographic parameters. Results The only statistical differences was found for shorter isovolumetric relaxation time (IRT) (40 ± 10 vs. 45 ± 9; p=0.03) and longer ejection time (ET) [ms] for right ventricle (RV) (176 ± 24 vs. 164 ± 18; p=0.01). Thick placenta was observed more frequent in study group than in controls (36.7 vs. 16.9%; p= 0.02). Conclusions The missing link for explanation of these findings was coincidence with thick placenta. This is probably the first observation suggesting that thick placenta (>5 cm) may affect fetal RV function in normal heart anatomy: prolongation of right ventricular ET and shortening of fetal right ventricular IVRT.

August 22, 2022

Knowledge and attitudes of pregnant women on maternal immunization against COVID-19 in Croatia

Tina Tatarević, Iva Tkalčec, Dorian Stranić, Goran Tešović, Ratko Matijević

Page range: 317-323

Abstract

Objectives The aim of this study was to assess pregnant women’s knowledge and attitudes regarding maternal COVID-19 immunization during pregnancy. Methods A cross-sectional study was performed in two teaching hospitals between May and October 2021 in Zagreb, Croatia. During antenatal clinic visit pregnant women were approached and asked to fill out a predesigned questionnaire about their knowledge and attitudes towards COVID-19 vaccination. Collected data was later analyzed. Results A total of 430 women participated in the study. Only 16% of women expressed their willingness to be vaccinated against COVID-19 if offered, despite that 71% of them believe that COVID-19 might be a serious illness in pregnant women. The most important obstacle in having better acceptance of the vaccines is in the assumption that the vaccines are not safe for pregnant women (73%) or the fetus (75%), or that the vaccines are not effective (41%). The relationship exists between acceptance of vaccination in general and willingness to get other vaccines in pregnancy and readiness to be vaccinated against COVID-19 in pregnancy. Only one out of 55 women who were not adherent to the current vaccination recommendations in Croatia would accept the COVID-19 vaccine during pregnancy if offered. 21 (5%) women stated that vaccination against influenza and pertussis during pregnancy is necessary and 13 (62%) of them would get vaccinated against COVID-19 if offered. Conclusions This study showed that the crucial reasons for refusing vaccination against COVID-19 among pregnant women in Croatia are the concerns about the vaccines’ effectiveness and safety. All healthcare providers should put more effort into education of pregnant women on risks of COVID-19, as well as on the benefits and safety of the vaccines.

August 11, 2022

Retrospective review of GCT cutoff value based on pre-pregnancy BMI class in patients with GDM

Kajal Angras, Victoria Boyd, Amanda J. Young, Awathif Dhanya Mackeen

Page range: 324-327

Abstract

Objectives To determine the optimal glucose challenge test (GCT) cutoff value for the screening of gestational diabetes mellitus (GDM) based on pre-pregnancy BMI. Methods An-IRB approved retrospective cohort analysis of singleton pregnancies at a large tertiary healthcare center from January 2004 to December 2020 was performed. The first GCT value completed between 20 and 32 weeks was used. Using a receiver operator curve (ROC), we sought to determine the optimal GCT cutoff value for each BMI category that would predict the development of GDM. Youden Index was used to determine optimal cut-point of GCT values for each BMI class. Results A total of 23,550 patients with a GCT value were identified. Of those, 1,676 (7.1%) were diagnosed with GDM. 513 (30.6%) with normal BMI, 449 (26.8%) overweight, 347 (20.7%) class I obese, 210 (12.5%) class II obese, and 157 (9.4%) class III obese patients were diagnosed with GDM. Gestational diabetes was predicted at GCT cutoff value of 130 mg/dL with an area under the curve (AUC) of 0.92 (BMI <25), 131 mg/dL with an AUC of 0.92 (overweight BMI), 131 mg/dL with an AUC of 0.89 (class I BMI), 133 mg/dL with an AUC of 0.88 (class II BMI), and 131 mg/dL with an AUC of 0.88 (class III BMI). Conclusions AUC ranged from 0.88 to 0.92 with 93% or greater sensitivity for GCT cutoff value across each of the BMI categories. The findings support a GCT cutoff value of 130 mg/dL for GDM screening regardless of BMI.

August 16, 2022

Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies

Bianca Debring, Mareike Möllers, Helen A. Köster, Robert Kwiecien, Janina Braun, Kathrin Oelmeier, Walter Klockenbusch, Ralf Schmitz

Page range: 328-336

Abstract

Objectives The aim of this study was to assess the value of cervical strain elastography and Cervical Sliding Sign (CSS) for predicting spontaneous preterm birth (sPTB). Methods In our case-control study we performed an elastographic assessment of the cervix in 82 cases of preterm birth (preterm group) and 451 control pregnancies (control group) between the 20th and 37th week of gestation. We divided the anterior cervical lip first into two (“Intern2”, “Extern2”) and into three sectors (“Intern3”, “Middle3”, “Extern3”). The tissue deformation pattern after local compression with an ultrasound probe was recorded. We distinguished between an irregularly distributed (“Spotting”) and homogeneous pattern presentation. Additionally, the presence of a sliding of the anterior against the posterior cervical lip (positive CSS) during compression was evaluated. A logistic regression analysis and the Akaike Information Criterion (AIC) were used to estimate the probability of sPTB and to select a prediction model. Results Spotting and positive CSS occurred more frequently in the preterm group compared to control group (97.8 vs. 2.2%, p<0.001; 26.8 vs. 4.2%, p<0.001; respectively). The model with the parameters week of gestation at ultrasound examination, Intern3, Middle3 and CSS was calculated as the highest quality model for predicting sPTB. The AUC (Area Under the Curve) was higher for this parameter combination compared to cervical length (CL) (0.926 vs. 0.729). Conclusions Cervical strain elastography pattern analysis may be useful for the prediction of sPTB, as the combination of Spotting analysis and CSS is superior to CL measurement alone.

August 15, 2022

Maternal race/ethnicity impacts the success rates of external cephalic version (ECV) in the United States

Samantha Gobioff, Yael Eliner, Erez Lenchner, Amos Grünebaum, Asaf Ferber, Frank A. Chervenak, Eran Bornstein

Page range: 337-339

Abstract

Objectives Racial and ethnic disparities in obstetrics are prevalent in the United States (US). We aimed to assess whether the success rate of external cephalic version (ECV) is affected by maternal race/ethnicity. Methods We conducted a retrospective analysis based on the CDC Natality Live Birth database for 2016–2018. We compared the success rates of ECV across US pregnant women of different racial/ethnic groups (non-Hispanic Whites, non-Hispanic Blacks, non-Hispanic Asians, and Hispanics) using the Pearson chi-square test and used multivariate logistic regression to control for confounding variables. Statistical signiciance was determined as p<0.05 and results were displayed as adjusted odds ratios (aOR) with 95% confidence intervals (95% CI). Results Of the 11,150,527 births, 26,255 women underwent an ECV and met inclusion criteria. The overall ECV success rate was 52.75% (13,850 women). Non-Hispanic Blacks had the highest ECV success rate (64.52%), followed by Hispanics (59.21%) and non-Hispanic Asians (55.51%). These rates were significantly higher than those of non-Hispanic Whites (49.27%, p<0.001). Non-Hispanic Blacks were associated with the highest success rate compared to non-Hispanic Whites (adjusted OR 1.95, 95% CI 1.77–2.15). Conclusions The success rate of ECV varies among different maternal racial/ethnic groups. Non-Hispanic White women have the lowest ECV success rate, while non-Hispanic Black women have the highest ECV success rate.

August 15, 2022

Fetal adrenal gland size and umbilical artery Doppler in growth-restricted fetuses

Kathrin Oelmeier, Mareike Möllers, Helen A. Köster, Daniela Willy, Eike Bormann, Janina Braun, Walter Klockenbusch, Ralf Schmitz

Page range: 340-345

Abstract

Objectives In fetal growth restriction (FGR), Doppler ultrasound is the most important method for the detection and management. However, additional parameters are needed to improve the distinction between constitutionally small fetuses and fetuses affected by FGR. Methods A total of 445 singleton pregnancies between 23 and 40 weeks of gestation were included in our retrospective study, of which 67 with FGR and 378 normal fetuses. A 2D-plane of the fetal adrenal gland was obtained and the adrenal gland ratio was measured. Spearman’s correlation coefficient was calculated to assess the association of fetal Doppler and adrenal gland ratio with outcome parameters. Logistic regression analysis was performed to assess the statistical significance of “PI of the umbilical artery” and “adrenal gland ratio” as prognostic factors for intrauterine growth restriction (IUGR). Results PI of the umbilical artery was shown to correlate with outcome parameters (WG_Delivery: r=−0.125, p=0.008; birth weight: r=−0.268, p<0.001; birth weight centile: r=−0.248, p<0.001; APGAR at 5 min: r=−0.117, p=0.014). Adrenal gland ratio showed no correlation with any of the outcome parameters. In logistic regression however, both PI of the umbilical artery and the adrenal ratio were shown to be significantly associated with fetal IUGR. When combining the two parameters, predictive value was superior to the predictive value of each individual parameter (AUC 0.738 [95% CI 0.670; 0.806]). Conclusions The adrenal gland ratio can be a useful addition to Doppler ultrasound when it comes to the detection of fetal FGR. Prospective studies are needed to establish references ranges and cut-off values for clinical decision-making.

August 23, 2022

Counseling pregnant women on calcium: effects on calcium intake

Jessica P.M.M. Willemse, Luc J.M. Smits, Mandy M.E. Braat, Linda J.E. Meertens, Pim van Montfort, Martien C. van Dongen, Jonas Ellerbrock, Ivo M.A. van Dooren, Ella. J. Duvekot, Iris M. Zwaan, Marc E.A. Spaanderman, Hubertina C.J. Scheepers

Page range: 346-355

Abstract

Objectives To evaluate the effect of incorporating calcium advice into early pregnancy counseling on calcium intake during pregnancy in the Netherlands. Methods A multicenter prospective before-after cohort study was conducted introducing risk-based care including calculating individual pre-eclampsia risk. Part of the intervention was to incorporate calcium advice into routine counseling. We calculated individual daily calcium intake and adequacy of calcium intake (≥1,000 mg/day) at 16, 24 and 34 weeks of pregnancy. We performed a multiple logistic regression adjusting for covariates to identify any differences in the risk of inadequate calcium intake between RC and CAC. Results In regular care (RC, 2013–2015, n=2,477) 60% had inadequate calcium intake, compared to 49% during calcium advice care (CAC, 2017–2018, n=774) (aOR 0.75, 95% CI 0.64–0.88). Specific calcium supplements were used by 2% and 29% in RC and CAC, respectively (OR 25.1, 95% CI 17.8–36.0). Determinants of an inadequate calcium intake were lower age (aOR per additional year 0.96, 95% CI: 0.94–0.98), nulliparity (aOR 1.22, 95% CI: 1.03–1.45) and non-Caucasian origin (aOR 1.83, 95% CI 1.09–3.09). In CAC, risk of inadequate intake decreased with increasing predicted pre-eclampsia risk, which was a trend reversal compared to RC. Conclusions Incorporating calcium advice into early pregnancy counseling was shown to lead to a decrease in the risk of inadequate calcium intake during pregnancy, but still inadequate intake in half of the women suggesting the need for further study on improving implementation. Awareness of individual increased PE risk had positive effect on calcium intake.

August 22, 2022

Relationship among anogenital distance, adrenal gland volume, and penile length and width at 22–36 weeks of pregnancy

Filiz Yarsilikal Guleroglu, Aliye Balkan Ozmen, Isil Turan Bakirci, Murat Ekmez, Ali Cetin

Page range: 356-362

Abstract

Objectives The subject of current work was to determine the relationship of fetal ultrasonographic biomarkers, including anogenital distance (AGD), adrenal gland volume, and penile length and width in mothers with male fetuses at 22–36 weeks of gestation for the assessment of the effect of fetal adrenal gland producing androgens on the male anogenital structures that are exposed to androgen effects as anogenital region and penis. Methods This study is a prospective cross-sectional study conducted in our hospital’s outpatient perinatal care unit. One hundred and seventy pregnant women with a male fetus aged 22–36 weeks of gestation were included in the study. The fetal adrenal gland length, width, and depth for the calculation of adrenal volume, AGD, and penile length and width were measured for each participant. The Pearson coefficients were calculated to assess the correlation among these parameters. Results The adrenal gland volume had a meaningful, positive moderate relationship with both the AGD (r=0.60) and penile length and width (r=0.57 and r=0.59, respectively; p<0.001). The AGD had a positive, strong correlation with the penile length and width (r=0.74 and r=0.76, respectively; p<0.001). Conclusions The fetal adrenal gland as one of the androgen sources of the fetus is an influencer of the development of the anogenital and penile region. The findings of the current study support that the adrenal gland considerably affects the masculinization of male fetuses, since there were remarkable correlations among the AGD, adrenal gland volume, and penile length and width.

Publicly Available September 29, 2022

Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood

Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch

Page range: 363-378

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Abstract

Objectives Intra-amniotic inflammation is a subclinical condition frequently caused by either microbial invasion of the amniotic cavity or sterile inflammatory stimuli, e.g., alarmins. An accumulating body of evidence supports a role for maternal immune activation in the genesis of fetal neuroinflammation and the occurrence of neurodevelopmental disorders such as cerebral palsy, schizophrenia, and autism. The objective of this study was to determine whether fetal exposure to mid-trimester intra-amniotic inflammation is associated with neurodevelopmental disorders in children eight to 12 years of age. Methods This is a retrospective case-control study comprising 20 children with evidence of prenatal exposure to intra-amniotic inflammation in the mid-trimester and 20 controls matched for gestational age at amniocentesis and at delivery. Amniotic fluid samples were tested for concentrations of interleukin-6 and C-X-C motif chemokine ligand 10, for bacteria by culture and molecular microbiologic methods as well as by polymerase chain reaction for eight viruses. Neuropsychological testing of children, performed by two experienced psychologists, assessed cognitive and behavioral domains. Neuropsychological dysfunction was defined as the presence of an abnormal score (<2 standard deviations) on at least two cognitive tasks. Results Neuropsychological dysfunction was present in 45% (9/20) of children exposed to intra-amniotic inflammation but in only 10% (2/20) of those in the control group (p=0.03). The relative risk (RR) of neuropsychological dysfunction conferred by amniotic fluid inflammation remained significant after adjusting for gestational age at delivery [aRR=4.5 (1.07–16.7)]. Of the 11 children diagnosed with neuropsychological dysfunction, nine were delivered at term and eight of them had mothers with intra-amniotic inflammation. Children exposed to intra-amniotic inflammation were found to have abnormalities in neuropsychological tasks evaluating complex skills, e.g., auditory attention, executive functions, and social skills, whereas the domains of reasoning, language, and memory were not affected in the cases and controls. Conclusions Asymptomatic sterile intra-amniotic inflammation in the mid-trimester of pregnancy, followed by a term birth, can still confer to the offspring a substantial risk for neurodevelopmental disorders in childhood. Early recognition and treatment of maternal immune activation in pregnancy may be a strategy for the prevention of subsequent neurodevelopmental disorders in offspring.

September 8, 2022

Genetic amniocentesis using atraumatic 29 gauge needle in patients having a chorioamniotic separation

Michael Tchirikov, Constanze Scheler, Martin Gericke, Andreas Wienke, Carola Jung, Michael Entezami

Page range: 379-386

Abstract

Objectives Chorioamniotic separation (CAS) at the time of standard amniocentesis (AC) is a risk factor for postprocedural complications and should be avoided. The aim of this study was to quantify procedure-related risks after AC with a 29G-needle in cases of CAS, and evaluation of perinatal outcome in CAS after 15 weeks’ gestation (GW). Methods Retrospective analysis of genetic AC with a pencil-point 29G needle after 15 completed GW in pregnancies, in which the fetal membranes were not yet fused. Included into the study were women aged 16–44 years with at least 15 completed GWs referred for second trimester AC to identify fetal chromosomal aberrations. Results 437 ACs were made in total with the 29G-needle. The median maternal age was 30 (16–44) years. 145 cases showed CAS where the distance between chorion and amnion was 0.10–10.02 mm at AC. 38 pregnancies were terminated, 37 of which had a genetic disorder. The risk of aneuploidy increases by a factor of 2 (95% CI 1.4–2.8) for every 1 mm of CAS enlargement. No procedure-related complications were found up to two weeks after the AC. Conclusions CAS seems to be massively underreported. Early diagnosis in case of CAS is something to strive for as CAS could be an indicator of genetic abnormalities – a “soft marker”. With the atraumatic 29G needle, the risk of complications after AC in CAS seems to be very low.

September 5, 2022

YouTube as a source of patient information on external cephalic version

Brinley M. Williams, Lindsey M. Le Poidevin, Mark A. Turrentine, Leah W. Antoniewicz

Page range: 387-391

Abstract

Objectives To assess the quality and content of information regarding external cephalic version on YouTube. Methods YouTube was searched using the phrase “external cephalic version” (ECV) to identify informative videos by two independent reviewers. Videos were included if: (1) in English; (2) available November 20, 2021; (3) related to ECV. Videos were excluded if: (1) duration exceeded 15 min; (2) target audience was not patients or the general public; (3) not in English; (4) were advertisements or news clips; (5) did not relate to ECV. The Global Quality Scale was used to assess overall quality of selected videos. A content score was developed based on guidelines from the American College of Obstetricians and Gynecologists. Video quality was also categorized as “slightly useful”, “useful” and “very useful”. The Patient Education Materials Assessment Tool (PEMAT) for audiovisual materials was used to score understandability and actionability. Results Of 60 videos screened, 31 met inclusion criteria. They were classified as People or Blogs (n=19, 61%) or Education (n=12, 39%). Videos were calculated to be “slightly useful” (n=10, 32%), “useful” (n=18, 58%), or “very useful” (n = 3, 10%). The PEMAT – understandability was less in the “slightly useful” compared to the combined “useful” and “very useful” groups, p<0.01. No differences existed between total usefulness score and category, p=0.6. Conclusions Most videos were useful, but few were very useful. These results highlight the importance of thorough counseling regarding this procedure.

September 13, 2022

Midwives’ personal and professional attitudes towards women’s delivery choices, interventions and neonatal care

Ailbhe Duffy, Chloe Maculey, Stephen W. Lindow, Michael P. O’Connell

Page range: 392-395

Abstract

Objectives Caesarean section (CS) rates in middle- and high-income countries are rising partly due to maternal request. This study aimed to explore the personal and professional attitudes of midwives and nurses towards women’s delivery choices, interventions and neonatal care. Methods Midwifery and nursing staff at the Coombe hospital were asked to complete a questionnaire concerning decisions for elective CS and neonatal care. The midwives’ responses were divided into multiparous and nulliparous according to their own parity. Results Multiparae and nulliparae did not differ on their personal preferences for their own baby. Only 3% wanted an elective CS in a normal, healthy pregnancy but this increased to 80.2% when there was a breech presentation and 42% if the estimated fetal weight was >4.5 kg. These numbers and trends were very close to the midwives’ professional recommendations under the same circumstances. The lower threshold for full resuscitation and ICU care was at 23 and 24 weeks gestation for both personal and professional recommendations. In the case of severely premature babies or babies with a poor prognosis, 54% stated that the approach to neonatal care was correct. Conclusions Overall, midwives’ professional views reflected what they would want for themselves and their babies. Only 3% recommended an elective CS in a normal, healthy pregnancy making it unlikely that midwives’ attitudes are driving the rise in CS rates in Ireland.

May 25, 2022

Maternal serum midkine level in fetal growth restriction: a case-control study

Deniz Oluklu, Dilek Menekse Beser, Derya Uyan Hendem, Ozgur Kara, Nuray Yazihan, Dilek Sahin

Page range: 396-402

Abstract

Objectives To compare maternal serum midkine (MK) level in pregnant women with idiopathic fetal growth restriction (FGR) and healthy. In addition, we assessed the value of maternal serum MK level in predicting neonatal intensive care unit (NICU) admission. Methods A total of 144 pregnant women were included, 72 with idiopathic FGR and 72 healthy in this study. The control group was matched for the mother’s age, parity, gestational age, and pre-pregnancy body mass index (BMI) with the idiopathic FGR group at the time of recruitment into the study and sample collection. Results Serum MK level is higher in the idiopathic FGR than the control group (0.24 ng/mL (0.19–0.32) vs. 0.18 ng/mL (0.14–0.23), p<0.001). In addition, we compared the maternal serum MK level of those with and without NICU admission in the FGR group (0.25 ng/mL (0.19–0.37) vs. 0.21 ng/mL (0.18–0.28), p=0.014). We performed ROC curve analysis to serum MK level predicting NICU admission in the FGR group (AUC: 0.668, %95 CI [0.550, 0.785], p=0.014). A sensitivity of 63% and a specificity of 62% for the serum MK level were achieved with a cut-off value of 0.22 for NICU admission. Conclusions To the best of our knowledge, this study is the first to compare maternal serum MK level in pregnant women with idiopathic FGR and healthy. We showed that maternal serum MK level was significantly elevated in pregnant women with FGR than healthy.

Original Articles – Neonates

Open Access October 31, 2022

Interventions for reducing late-onset sepsis in neonates: an umbrella review

Abdul Razak, Omar Ibrahim Alhaidari, Javed Ahmed

Page range: 403-422

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Abstract

Objectives Neonatal sepsis is one of the leading causes of neonatal deaths in neonatal intensive care units. Hence, it is essential to review the evidence from systematic reviews on interventions for reducing late-onset sepsis (LOS) in neonates. Methods PubMed and the Cochrane Central were searched from inception through August 2020 without any language restriction. Cochrane reviews of randomized clinical trials (RCTs) assessing any intervention in the neonatal period and including one or more RCTs reporting LOS. Two authors independently performed screening, data extraction, assessed the quality of evidence using Cochrane Grading of Recommendations Assessment, Development and Evaluation, and assessed the quality of reviews using a measurement tool to assess of multiple systematic reviews 2 tool. Results A total of 101 high-quality Cochrane reviews involving 612 RCTs and 193,713 neonates, evaluating 141 interventions were included. High-quality evidence showed a reduction in any or culture-proven LOS using antibiotic lock therapy for neonates with central venous catheters (CVC). Moderate-quality evidence showed a decrease in any LOS with antibiotic prophylaxis or vancomycin prophylaxis for neonates with CVC, chlorhexidine for skin or cord care, and kangaroo care for low birth weight babies. Similarly, moderate-quality evidence showed reduced culture-proven LOS with intravenous immunoglobulin prophylaxis for preterm infants and probiotic supplementation for very low birth weight (VLBW) infants. Lastly, moderate-quality evidence showed a reduction in fungal LOS with the use of systemic antifungal prophylaxis in VLBW infants. Conclusions The overview summarizes the evidence from the Cochrane reviews assessing interventions for reducing LOS in neonates, and can be utilized by clinicians, researchers, policymakers, and consumers for decision-making and translating evidence into clinical practice.

September 29, 2022

Maternal knowledge of recommendations for safe infant sleep and intentions for implementation – a cross sectional analysis of data from the KUNO-Kids birth cohort study

Sara Fill Malfertheiner, Janina Postpischil, Vincent D. Gaertner, Susanne Brandstetter, Alan J. Metcalfe, Birgit Seelbach-Göbel, Christian Apfelbacher, Michael Melter, Michael Kabesch, Sebastian Kerzel

Page range: 423-431

Abstract

Objectives Despite major advances in prevention, sudden infant death syndrome (SIDS) remains an important cause of infant mortality. The aim of our study was to determine actual knowledge and intentions to implement SIDS prevention measures among new mothers and to identify potential knowledge gaps for improved postpartum counselling strategies. Methods Data was collected in a standardized interview from participants of the KUNO-Kids birth cohort study before discharge from maternity ward. The mothers did not receive any specific teaching prior to the interview. Results The majority of 2,526 interviewed mothers were able to actively report important recommendations for safe infant sleep, including the exclusive face-up position. However, 154 mothers (9%) intended to position the newborn face-down sometimes or often. The most frequently envisaged sleeping furniture was a bedside sleeper (n=1,144, 47%), but 2.2% of mothers indicated that the intended default sleeping place for the newborn would be the parents’ bed (which is discouraged by the recommendations). For 43% of the infants (n=1,079), mothers planned to have loose objects in the bed and 189 mothers (7%) intended to use a loose blanket. 22% of infants (n=554) will live in a household with a smoker. Multivariate regression showed a significant association of “good knowledge” with maternal age and with not being a single parent, whereas the household size was negatively associated. Conclusion Although the majority of mothers in our birth cohort were aware of many recommendations for safe infant sleep, our data also uncovered weaknesses in SIDS prevention knowledge and point to specific areas with potential for improved counselling.

Short Communication

September 12, 2022

Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids

Katherine J. Kramer, Neeraja Purandare, Siddhesh Aras, Fatemeh Parsian, Sandra Sadek, Conrad Chao, Robert A. Welch, Maurice-Andre Recanati

Page range: 432-434

Abstract

Objectives Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is involved in the production of fetal lung surfactant. We have shown that LPCAT1 mRNA is present in amniotic fluid and maternal plasma and that its quantity correlates with the amniotic fluid lamellar body count. The purpose of the present study was to assay maternal plasma for the LPCAT1 protein in term and preterm pregnancies; and to measure the impact of antenatal corticosteroids. Methods Maternal and newborn plasma samples were obtained from 7 women admitted to the hospital for induction of labor. Maternal plasma was also obtained before administration of corticosteroids and 24 h after the second dose of corticosteroids from 12 women with premature labor and premature rupture of membranes. After sample preparation, LPCAT1 protein levels were determined using sandwich ELISA. Results We discovered LPCAT1 protein in maternal plasma in measurable quantities after 32 weeks gestation. Further, there was a rise of maternal plasma LPCAT1 in response to the clinical administration of antenatal corticosteroids. Conclusions Quantitation of maternal plasma LPCAT1 protein offers promise in the ongoing study of fetal lung maturation.

Letters to the Editor

August 11, 2022

Peripartum hysterectomy at a tertiary university perinatal center – retrospective analysis of the 25-year period

Matija Prka, Dubravko Habek, Ingrid Marton, Leila Mitrović, Edgar Glavaš, Ana-Meyra Potkonjak

Page range: 435-436

August 8, 2022

Neonate, infected mother and monkeypox: the present concern

Pathum Sookaromdee, Viroj Wiwanitkit

Page range: 437-437

Ahead of Print / Just Accepted

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5-year Impact Factor	2.322
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Editorial

Editor-in-Chief
Joachim W. Dudenhausen, Berlin, Germany

Founding Editor
Erich Z. Saling, Berlin, Germany

Coordinating Editor for the WAPM
Frank A. Chervenak, New York, US

Coordinating Editor for the IAPM
Asim Kurjak, Zagreb, Croatia

Associate Editors Obstetrics
Thorsten Braun, Berlin, Germany
Vincenzo D’Addario, Bari, Italy
Mehmet Genc, Gainesville, US
Amos Grunebaum, New York, US
Roberto Romero, Detroit, US
Daniel W. Skupski, New York, US
Ivica Zalud, Honolulu, US

Associate Editors Neonatology
Marty Ellington, New York, NY, US
Anne Greenough, London, UK

Editorial Board
Haim Abenhaim, Montreal, Canada
João F. Bernardes, Porto, Portugal
Jonathan Blau, Staten Island, NY, US
Eran Bornstein, New York, US
Luis Cabero, Barcelona, Spain
Xavier Carbonell-Estrany, Barcelona, Spain
Erich Cosmi, Padua, Italy
Mary E. D’Alton, New York, US
Dan Farine, Toronto, Canada
Sonia S. Hassan, Detroit, US
Roland Hentschel, Freiburg, Germany
Wolfgang Holzgreve, Bonn, Germany
Ben Lee, Doha, Quartar
Karel Maršál, Lund, Sweden
Jorge C. Martinez, Buenos Aires, Argentina
Zoltan Papp, Budapest, Hungary
Ranjan K. Pejaver, Bangalore, India
Ritsuko K. Pooh, Osaka, Japan
Giuseppe Rizzo, Rome, Italy
Ola D. Saugstad, Oslo, Norway
Joseph Schenker, Jerusalem, Israel
Klaus Vetter, Berlin, Germany
Alexander Weichert, Berlin, Germany
Hung N. Winn, Columbia, US
Bruce K. Young, New York, US
Roland Zimmermann, Zurich, Switzerland

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Nicola Volpe, Parma, Italy

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Frank A. Chervenak, New York

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(Deutsch)

Online ISSN: 1619-3997
Print ISSN: 0300-5577
Type: Journal
Language: English
Publisher: De Gruyter
First published: January 1, 1973
Publication Frequency: 9 Issues per Year
Audience: researchers and health professionals in the field of perinatal and related research