The impact of transnational migration and globalization on human society, along with emerging multiple identities, calls for reconceptualization of the meaning of cultural competence and a shift toward transcultural competence—a mode of being and learning in which humans communicate and interact among cultures in a very diverse and dynamic environment. Embracing transculturalism perspective calls for integration of new concepts and approaches in communication and education that promote active participation, adaptation, and interaction. To this end, this essay examines the holistic model for developing transcultural competence that involves inquiry, framing, and positionality that challenge our taken-for-granted frames of references and expand our worldviews. The study also explores how educators and learners develop cognitive, emotional, and social qualities, engaging in dialog and critical reflection that informs our actions as the catalyst for positive social change and transformation. Implementing this holistic perspective toward transcultural education can create an inclusive environment for communicating, interacting, and learning without opposing cultural, national, and ethnic binaries.