In this study, new calculations of the excitation functions of 56 Fe(p,2n) 55 Co, 58 Fe(p,2n) 57 Co, 60 Ni(p,n) 60 Cu, 62 Ni(p,2n) 61 Cu, 68 Zn(p,2n) 67 Ga, 72 Ge(p,n) 72 As, 82 Kr(p,2n) 81 Rb, 124 Xe(p,2n) 123 Cs, 112 Cd(p,2n) 111 In and 203 Tl(p,3n) 201 Pb reactions have been carried for incident proton energies up to 50 MeV. In these calculations, the pre-equilibrium and equilibrium effects have been investigated. The pre-equilibrium calculations involve the newly evaluated geometry-dependent hybrid model, hybrid model and the cascade exciton model. Equilibrium effects are calculated according to the Weisskopf–Ewing model. The calculated results are compared with the experimental data taken from the literature.