In this study, production routes of medical 110,111 In radionuclides produced by 110 Cd(p, n) 110 In, 111 Cd(p, 2n) 110 In, 112 Cd(p, 3n) 110 In, 107 Ag(α, n) 110 In, 109 Ag(α, 3n) 110 In, 111 Cd(p, n) 111 In, 112 Cd(p, 2n) 111 In, 113 Cd(p, 3n) 111 In, 114 Cd(p, 4n) 111 In, 109 Ag(α, 2n) 111 In, 107 Ag(α, γ) 111 In and 113 In(n, 3n) 111 In reactions have been investigated up to 70 MeV incident particle energy. In these calculations, the pre-equilibrium and equilibrium effects have been investigated. The pre-equilibrium calculations involve the geometry dependent hybrid model and the cascade exciton model. The full exciton model has also been used to investigate the pre-equilibrium direct effects. Equilibrium effects are calculated according to the Weisskopf–Ewing model. The calculated results are compared with the experimental data taken from the literature.