Because of the uncertainties associated with the definition of Critical Heat Flux (CHF), the best estimate approach should be used. In this paper the application of best-estimate approach for the analysis of CHF phenomenon in the boiling water reactors is presented. At first, the nodalization of RBMK-1500, BWR-5 and ABWR fuel assemblies were developed using RELAP5 code. Using developed models the CHF and Critical Heat Flux Ratio (CHFR) for different types of reactors were evaluated. The calculation results of CHF were compared with the well-known experimental data for light water reactors. The uncertainty and sensitivity analysis of ABWR 8 × 8 fuel assembly CHFR calculation result was performed using the GRS (Germany) methodology with the SUSA tool. Finally, the values of Minimum Critical Power Ratio (MCPR) were calculated for RBMK-1500, BWR-5 and ABWR fuel assemblies. The paper demonstrate how, using the results of sensitivity analysis, to receive the MCPR values, which covers all uncertainties and remains best estimated.