In this paper, a 5 MW open pool type research reactor is simulated and analyzed to check and pass a complete and practical safety assessment against various LOFA scenarios. Generally, LOFA may occur in a research reactor when the reactor primary pump or the safety flapper valve fail. The simulation includes the study of a downward core cooling system circulated by the gravity driven force, the performance and failure effects of the safety flapper valve, the flow reversal mode and transition, the natural convection mode, different possible types of LOFA, and impacts of the surrounding empty boxes. First of all, the code nodalization is successfully benchmarked against available experimental data of the reactor operating parameters. Then, all possible DBAs in this field of study are simulated and discussed in detail. Results are completely satisfactory to simulate and analyze a pool-type research reactor in response to LOFA using the RELAP5 code. Furthermore, transients including the natural convection mode and even flow reversal mode are following naturally without any oscillation or source of errors. Finally, TRR is completely safe against the DBA type of LOFA scenarios.