The fate of the Serapeum and especially of its library is still a hotly-debated topic. The present paper aims to provide a consistent reading of the extant source evidence. Christian authors, such as Tertullian, Epiphanius of Salamis, and John Chrysostom, acknowledge that the Septuagint bible translation was moved from the original royal library to the Serapeum by the end of the second century A.D. This could be because the Serapeum had become Alexandria’s main library after the temple was rebuilt following a fire in 181 A.D. Writing in the early fifth century, Orosius is our most important witness that the Christian mob destroyed not only the temple building, but also the library and that this library was the successor of the original Ptolemaic library. There are several other possible allusions to the destruction of the library, for example, in sermons delivered by John Chrysostom in the 390s. This article also argues that Ammianus Marcellinus, Aphthonius, and Epiphanius of Salamis were aware of the destruction of the library when they wrote their descriptions of the Serapeum probably not before 391. Taken together, these sources illuminate the ways in which events of such magnitude broke very quickly in various parts of the Roman empire. Nevertheless, some authors, especially the pagan ones, were hesitant to refer to the destruction other than in allusive and muted ways, probably because of the heated religious atmosphere in the immediate aftermath.