Ceased

Published from January 1, 2017 to November 1, 2022

Neuroforum

Organ der Neurowissenschaftlichen Gesellschaft

ISSN: 2363-7013

Editor-in-chief: Petra Wahle

About this journal

This journal has ceased publication. Neuroforum was published from 1995 till 2022. It was the official journal of the German Neuroscience Society (GNS) / Neurowissenschaftliche Gesellschaft e.V. (NWG).
The main scientific articles of Neuroforum will appear in solely electronic form on the web portal dasGehirn.info (https://www.dasgehirn.info/) starting in 2023.

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Publication Ethics and Publication Malpractice Statement

Volume 28 Issue 4

November 2022

Publicly Available November 28, 2022

Frontmatter

Page range: i-iii

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Editorial

November 28, 2022

Neuroforum: vom gedruckten Heft ins elektronische Zeitalter

Christine R. Rose, Frank Kirchhoff

Page range: 197-198

Review articles

Open Access October 11, 2022

The visual representation of space in the primate brain

Stefan Dowiasch, Andre Kaminiarz, Frank Bremmer

Page range: 199-209

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Abstract

One of the major functions of our brain is to process spatial information and to make this information available to our motor systems to interact successfully with the environment. Numerous studies over the past decades and even centuries have investigated, how our central nervous system deals with this challenge. Spatial information can be derived from vision. We see, where the cup of coffee stands at the breakfast table or where the un-mute-button of our video-conference tool is. However, this is always just a snapshot, because the location of the projection of the cup or the un-mute-button shifts across the retina by each eye movement, i.e., 2–3 times per second. So, where exactly in space are objects located? And what signals guide self-motion and navigation through our environment? While also other sensory signals (vestibular, tactile, auditory, even smell) can help us localize objects in space and guide our navigation, here, we will focus on the dominant sense in primates: vision. We will review (i) how visual information is processed to eventually result in space perception, (ii) how this perception is modulated by action, especially eye movements, at the behavioral and at the neural level, and (iii) how spatial representations relate to other encodings of magnitude, i.e., time and number.

October 7, 2022

MicroRNAs in the auditory system: tiny molecules with big impact

Lena Ebbers, Faiza Altaf, Hans Gerd Nothwang

Page range: 211-221

Abstract

“Blindness separates from things; deafness separates from people.” This quote attributed to the deaf-blind author and activist Helen Keller (1880–1968) indicates the importance of proper hearing for social interaction in our society which is largely driven by acoustic communication. A major cause for auditory dysfunction lies in our genome with currently more than 100 genes linked to hearing loss. One example is the microRNA gene Mir-96 of the microRNA-183 family. MicroRNAs are small regulatory RNAs involved in the finetuning of gene expression. Analyses of transgenic mouse models established this microRNA family as a major regulator for the function of the inner ear as well as synaptic transmission in the auditory brainstem. The microRNA-183 family might therefore play an important role in coordinating the development of the peripheral and central auditory system and their specializations.

November 2, 2022

Non-coding repeat expansions associated with familial adult myoclonic epilepsy: a new paradigm of gene-independent monogenic disorders

Theresa Kühnel, Christel Depienne

Page range: 223-232

Abstract

Familial adult myoclonic epilepsy (FAME) is a rare autosomal dominant disorder characterized by cortical myoclonic tremor and seizures. FAME has been mapped to chromosomes (chr) 2, 3, 5 and 8, but the cause has remained elusive for more than a decade. An expansion of intronic TTTTA and TTTCA repeats in SAMD12 was identified as the cause of FAME1 in Japanese families linked to chr 8 in 2018. This discovery triggered the identification of identical repeat expansions at five additional loci (FAME2: STARD7 ; FAME3: MARCHF6 ; FAME4: YEATS2 ; FAME6: TNRC6A and FAME7: RAPGEF2 ). These genes encode proteins with different functions and subcellular localizations and their expression is unaltered in available peripheral tissues, suggesting that the expansion is pathogenic independently of the gene itself. The pathophysiological mechanisms are not yet known but possibly include toxicity at the RNA level or translation of toxic polypeptides from the repeats, a mechanism known as repeat-associated non-AUG (RAN) translation. FAME is a paradigm of human genetic disorder caused by a non-coding expansion unrelated to the gene where it occurs.

October 24, 2022

Forebrain development–an intricate balance decides between health and disease

Tamrat Meshka Mamo, Annette Hammes

Page range: 233-243

Abstract

Patients carrying pathogenic gene variants encoding factors linked to the sonic hedgehog (SHH) pathway suffer from severe congenital brain malformations including holoprosencephaly (HPE). A poorly understood feature of these common anomalies is the highly variable penetrance, even amongst family members, carrying the same mutation. Modifier genes–genetic variants that can affect the phenotypic outcome of the primary disease-causing gene–contribute to this variability within pedigrees. Modifier genes can confer resilience or susceptibility to a disease, but are difficult to identify in humans. Studying the complex genetic interactions in mouse models of human congenital disorders can be instrumental in the identification of genes, that powerfully modulate SHH signaling pathway capacity and ultimately the penetrance of genetic disturbances. Understanding the underlying complex molecular mechanisms of disease aetiology and can support directing future genetic linkage studies in humans.

Presentation of scientific institutions

September 22, 2022

Collaborative Research Centre (CRC 1451) “Key mechanisms of motor control in health and disease”

Gereon R. Fink, Silvia Daun, Christian Grefkes

Page range: 245-246

September 5, 2022

Collaborative Research Center SFB 1528 “Cognition of Interaction”

Alexander Gail

Page range: 247-248

September 15, 2022

SPP2411: ‘Sensing LOOPS: cortico-subcortical interactions for adaptive sensing’

Livia de Hoz, Laura Busse, Julio C. Hechavarria, Alexander Groh, Markus Rothermel

Page range: 249-251

September 8, 2022

Newly DFG-funded research training group at the University of Kassel: “Biological clocks on multiple time scales” GRK 2749/1

Monika Stengl, Jenny Aino Plath, Susanne Neupert, Thordis Arnold

Page range: 253-254

Nachrichten

November 8, 2022

Catching up in Cologne – 31st Neurobiology Doctoral Students Workshop in Cologne

Angelina Ruthe, Rebecca Figge-Schlensok

Page range: 255-257

Nachrichten aus der Gesellschaft

November 14, 2022

Nachrichten aus der Gesellschaft

Page range: 259-262

Volume 28 (2022)

Volume 27 (2021)

Volume 26 (2020)

Volume 25 (2019)

Volume 24 (2018)

Volume 23 (2017)

Volume 22 (2016)

Volume 21 (2015)

Volume 20 (2014)

Volume 19 (2013)

Volume 18 (2012)

Volume 17 (2011)

Volume 16 (2010)

Volume 15 (2009)

Volume 14 (2008)

Volume 13 (2007)

Volume 12 (2006)

Volume 11 (2005)

Volume 10 (2004)

Volume 9 (2003)

Volume 8 (2002)

Volume 7 (2001)

Volume 6 (2000)

Volume 5 (1999)

Volume 4 (1998)

Volume 3 (1997)

Volume 2 (1996)

Volume 1 (1995)

CiteScore	1.2
SCImago Journal Rank	0.224
Source Normalized Impact per Paper	0.218

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Hybrid Open Access

In this journal, authors have the option to publish their article under an open access license. Open Access allows you as an author to retain copyright and share your findings with colleagues and interested parties worldwide without any restraints.
Please note that authors from institutions with which we have a transformative agreement can publish open access without paying an article processing charge (APC). More information on the eligible institutions and articles can be found under the "Funding and Support" tab here.

Editorial

Chefredakteurin
Prof. Dr. Petra Wahle
AG Entwicklungsneurobiologie
Fachbereich Biologie
Ruhr-Universität Bochum
Universitätsstraße 150
44801 Bochum
eMail: petra.wahle@ruhr-uni-bochum.de

Redaktion
Susanne Hannig
Redaktion Neuroforum
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Str. 10
13092 Berlin-Buch
eMail: susanne.hannig@mdc-berlin.de

Redaktionsgremium
Prof. Dr. Nikolai Axmacher (Bochum)
Prof. Dr. Mathias Bähr (Göttingen)
Prof. Dr. Niels Birbaumer (Tübingen)
Prof. Dr. Alexander Borst (Martinsried)
Prof. Dr. Sebastian Brandner (London, Großbritannien)
Prof. Dr. Katharina Braun (Magdeburg)
Prof. Dr. Nils Brose (Göttingen)
Prof. Dr. Ansgar Büschges (Köln)
Prof. Dr. Thomas Deller (Frankfurt am Main)
Prof. Dr. Ricarda Diem (Heidelberg)
Prof. Dr. Ulrich Dirnagl (Berlin)
Prof. Dr. Andreas Draguhn (Heidelberg)
Prof. Dr. Jens Eilers (Leipzig)
Prof. Dr. Herta Flor (Mannheim)
Prof. Dr. Eckhard Friauf (Kaiserslautern)
Prof. Dr. Giovanni Galizia (Konstanz)
Prof. Dr. Magdalena Götz (München)
Prof. Dr. Benedikt Grothe (München)
Prof. Dr. Sonja Grün (Jülich)
Prof. Dr. Onur Güntürkün (Bochum)
Prof. Dr. Eckhart Gundelfinger (Magdeburg)
Prof. Dr. Ileana Hanganu-Opatz (Hamburg)
Prof. Dr. Andreas Heinz (Berlin)
Prof. Dr. Charlotte Helfrich-Förster (Würzburg)
Dr. Moritz Helmstädter (Frankfurt am Main)
Prof. Dr. Michael Heneka (Bonn)
Prof. Dr. Anton Hermann (Salzburg, Österreich)
Prof. Dr. Andreas Herz (München)
Prof. Dr. Isabella Heuser (Berlin)
Prof. Dr. Sigismund Huck (Wien, Österreich)
Prof. Dr. Mark Hübener (Martinsried)
Prof. Dr. Reinhard Jahn (Göttingen)
Prof. Dr. Sabine Kastner (Princeton, USA)
Prof. Dr. Helmut Kettenmann (Berlin)
Prof. Dr. Frank Kirchhoff (Homburg)
Prof. Dr. Christian Klämbt (Münster)
Prof. Dr. Thomas Klockgether (Bonn)
Prof. Dr. Matthias Kneussel (Hamburg)
Prof. Dr. Michael Koch (Bremen)
Prof. Dr. Arthur Konnerth (München)
Prof. Dr. Sigrun Korsching (Köln)
Prof. Dr. Kerstin Krieglstein (Freiburg)
Prof. Dr. Trese Leinders-Zufall (Homburg)
Prof. Dr. Wolfgang Löscher (Hannover)
Prof. Dr. Siegrid Löwel (Göttingen)
Prof. Dr. Albert Ludolph (Ulm)
Prof. Dr. Hanspeter Mallot (Tübingen)
Prof. Dr. Denise Manahan-Vaughan (Bochum)
Prof. Dr. Thomas Möller (Cambridge, USA)
Prof. Dr. Ulrike Müller (Heidelberg)
Prof. Dr. Thomas Münte (Lübeck)
Prof. Dr. Roger Nitsch (Zürich, Schweiz)
Prof. Dr. Christian Pape (Münster)
Prof. Dr. Hans-Joachim Pflüger (Berlin)
Prof. Dr. Josef Rauschecker (Washington, USA)
Prof. Dr. Angelika Richter (Leipzig)
Prof. Dr. Christine Rose (Düsseldorf)
Prof. Dr. Stefan Rotter (Freiburg)
Prof. Dr. Isabella Sarto-Jackson (Klosterneuburg, Österreich)
Prof. Dr. Susanne Schoch-McGovern (Bonn)
Prof. Dr. Rainer Schwarting (Marburg)
Prof. Dr. Mikael Simons (Göttingen)
Prof. Dr. Christian Steinhäuser (Bonn)
Prof. Dr. Monika Stengl (Kassel)
Prof. Dr. Christiane Thiel (Oldenburg)
Prof. Dr. Stefan Treue (Göttingen)
Prof. Dr. Petra Wahle (Bochum)
Prof. Dr. Bernd Weber (Bonn)
Prof. Dr. Christian Wegener (Würzburg)
Prof. Dr. Florentin Wörgötter (Göttingen)

(Deutsch)

Online ISSN: 2363-7013
Type: Journal
Languages: German, English
Publisher: De Gruyter
First published: January 1, 2017
Last published: November 1, 2022
Publication Frequency: 4 Issues per Year