As a growing number of contemporary American novelists take the world and its socio-cultural and geopolitical complexity as their subject matter, the contemporary novel’s form and sense of worldliness are shifting. Twenty-first century US fiction challenges normative models of the world proposed by theories of cosmopolitan relationality by projecting fragile worlds of strife and trauma, in which violence accompanies geopolitical turbulence. In these novels, discourses around human security—the everyday security needs of vulnerable populations—are increasingly prominent. Accordingly, contemporary US fiction often incorporates within its geopolitical imaginary such issues as human rights, humanitarian interventions, development, and how life is disabled by prejudice, civil war, scarcity, and health or other crises. In this essay, I range across a number of works by contemporary American novelists such as Dave Eggers, Jennifer Egan, Denis Johnson, Dana Spiotta, and Bob Shacochis in which state failures as well as human and geopolitical security concerns impact on the form given to the world by these novelists. In their novels, narratives concerning human security as well as threats to geopolitical stability produce transnational geographies in which global interconnections and circulation intensify feelings of insecurity.