Using mathematical modeling and computational analysis, this study aims to examine the peristaltic blood flow of a non-Newtonian material in a tapered channel with radiative heat flux and response mechanisms. By utilizing a long-wavelength approximation, ignoring the wave number, and performing under conditions of low Reynolds number, closed form solutions for the velocity, temperature, and concentration fields are achieved. Several governing parameters and their effects on the system were analyzed, and relevant diagrams were provided. Increasing the Biot number, Jeffrey material, and thermal radiation parameter of the heat and mass transfer mechanism increases the velocity profile. When the heat source/sink parameter and the heat transfer Biot number increase, the temperature profile improves. The resultant concentration distributions are enhanced when mass transfer Biot number, heat radiation, and chemical processes are all raised. We observe that the pressure rate decreases in all three pumping zones when the heat transfer Grashof number and heat transfer Biot number rise. This is because the pressure rate is affected by the Grashof number and Biot number of heat transmission. The increase in thermal radiation parameter and heat transfer Biot number results in a slower rate of heat transfer than when Prandtl number and heat source/sink parameter increases. When the Soret number, Schmidt number, Biot number, and heat source/sink parameter are all raised, the mass transfer coefficient also rises. This rate, however, decreases as the heat radiation and chemical reaction parameters rise. The findings presented in this study have interesting implications for other aspects of human physiology. The preponderance of organs are permeable. Furthermore, fluids render the location of natural boundaries uncertain. The presented mathematical model can be used to derive predictions about the behavior of various systems. For the study of cancer treatment in biological systems, a mathematical model that includes nanoparticles, viscosity dissipation, and rotation holds much promise. Model development incorporated Soret–Dufour effects and thermal analysis of the digestive system.