Impact Factor: 4.1

Published since April 1, 1987

Reviews in the Neurosciences

ISSN: 2191-0200

Editor-in-chief: Joseph P. Huston

Editorial Board: Bianca Topic, Hojjat Adeli, Gyorgy Buzsaki, Jacqueline Crawley, Tim Crow, Paul Gold, Florian Holsboer, Carsten Korth, Jay-Shake Li, Gert Lubec, Bruce McEwen, Weihong Pan, Mikhail Pletnikov, Trevor Robbins, Alfons Schnitzler, Oswald Steward

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About this journal

Reviews in the Neurosciences provides a forum for reviews, critical evaluations and theoretical treatment of selective topics in the neurosciences. The journal is meant to provide an authoritative reference work for those interested in the structure and functions of the nervous system at all levels of analysis, including the genetic, molecular, cellular, behavioral, cognitive and clinical neurosciences. Contributions should contain a critical appraisal of specific areas and not simply a compilation of published articles.

Previously published by Freund Publishing House Ltd.

Topics

Neurology
Psychiatry
Neuropharmacology
Neurochemistry
Neurophysiology
Behavioral Psychology
Pharmacology
Neuroanatomy

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Reviews

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Your Benefits

Rich publishing tradition since 1987
Critical approach to neurosciences
Comprehensive overview of all levels of analysis
Pioneering contributions bringing you up to date
Online publication ahead of print

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Previously published by Freund Publishing House Ltd.

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Volume 34 Issue 8

December 2023

Publicly Available November 24, 2023

Frontmatter

Page range: i-iii

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Publicly Available March 27, 2023

Efficient, continual, and generalized learning in the brain – neural mechanism of Mental Schema 2.0 –

Takefumi Ohki, Naoto Kunii, Zenas C. Chao

Page range: 839-868

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Abstract

There has been tremendous progress in artificial neural networks (ANNs) over the past decade; however, the gap between ANNs and the biological brain as a learning device remains large. With the goal of closing this gap, this paper reviews learning mechanisms in the brain by focusing on three important issues in ANN research: efficiency, continuity, and generalization. We first discuss the method by which the brain utilizes a variety of self-organizing mechanisms to maximize learning efficiency, with a focus on the role of spontaneous activity of the brain in shaping synaptic connections to facilitate spatiotemporal learning and numerical processing. Then, we examined the neuronal mechanisms that enable lifelong continual learning, with a focus on memory replay during sleep and its implementation in brain-inspired ANNs. Finally, we explored the method by which the brain generalizes learned knowledge in new situations, particularly from the mathematical generalization perspective of topology. Besides a systematic comparison in learning mechanisms between the brain and ANNs, we propose “Mental Schema 2.0,” a new computational property underlying the brain’s unique learning ability that can be implemented in ANNs.

May 8, 2023

Current status of Guillain–Barré syndrome (GBS) in China: a 10-year comprehensive overview

Yanna Song, Xiaoxiao Zheng, Yong Fang, Shan Liu, Kangding Liu, Jie Zhu, Xiujuan Wu

Page range: 869-897

Abstract

Guillain–Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy; a disease involving the peripheral nervous system which is the most common cause of acute flaccid paralysis worldwide. So far, it is still lack of a comprehensive overview and understanding of the national epidemiological, clinical characteristics, and the risk factors of GBS in China, as well as differences between China and other countries and regions in these respects. With the global outbreak of the coronavirus disease 2019 (COVID-19), an epidemiological or phenotypic association between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and GBS has attracted great attention. In this review, we outlined the current clinical data of GBS in China by retrieving literature, extracting and synthesizing the data of GBS in China from 2010 to 2021. Besides, we compared the characteristics of epidemiology, preceding events and clinical profiles of GBS between China and other countries and regions. Furthermore, in addition to conventional intravenous immunoglobulin (IVIG) and plasma exchange (PE) therapy, the potential therapeutic effects with novel medications in GBS, such as complement inhibitors, etc., have become the research focus in treatments. We found that epidemiological and clinical findings of GBS in China are approximately consistent with those in the International GBS Outcome Study (IGOS) cohort. We provided an overall picture of the present clinical status of GBS in China and summarized the global research progress of GBS, aiming to further understand the characteristics of GBS and improve the future work of GBS worldwide, especially in countries with the middle and low incomes.

Publicly Available June 8, 2023

The role of pain modulation pathway and related brain regions in pain

Dandan Yao, Yeru Chen, Gang Chen

Page range: 899-914

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Abstract

Pain is a multifaceted process that encompasses unpleasant sensory and emotional experiences. The essence of the pain process is aversion, or perceived negative emotion. Central sensitization plays a significant role in initiating and perpetuating of chronic pain. Melzack proposed the concept of the “pain matrix”, in which brain regions associated with pain form an interconnected network, rather than being controlled by a singular brain region. This review aims to investigate distinct brain regions involved in pain and their interconnections. In addition, it also sheds light on the reciprocal connectivity between the ascending and descending pathways that participate in pain modulation. We review the involvement of various brain areas during pain and focus on understanding the connections among them, which can contribute to a better understanding of pain mechanisms and provide opportunities for further research on therapies for improved pain management.

Open Access July 7, 2023

Transsulfuration pathway: a targeting neuromodulator in Parkinson’s disease

Andrea Corona-Trejo, María E. Gonsebatt, Cristina Trejo-Solis, Victoria Campos-Peña, Laura Itzel Quintas-Granados, Edgar Yebrán Villegas-Vázquez, Octavio Daniel Reyes-Hernández, Vicente Jesús Hernández-Abad, Gabriela Figueroa-González, Daniela Silva-Adaya

Page range: 915-932

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Abstract

The transsulfuration pathway (TSP) is a metabolic pathway involving sulfur transfer from homocysteine to cysteine. Transsulfuration pathway leads to many sulfur metabolites, principally glutathione, H 2 S, taurine, and cysteine. Key enzymes of the TSP, such as cystathionine β-synthase and cystathionine γ-lyase, are essential regulators at multiple levels in this pathway. TSP metabolites are implicated in many physiological processes in the central nervous system and other tissues. TSP is important in controlling sulfur balance and optimal cellular functions such as glutathione synthesis. Alterations in the TSP and related pathways (transmethylation and remethylation) are altered in several neurodegenerative diseases, including Parkinson’s disease, suggesting their participation in the pathophysiology and progression of these diseases. In Parkinson’s disease many cellular processes are comprised mainly those that regulate redox homeostasis, inflammation, reticulum endoplasmic stress, mitochondrial function, oxidative stress, and sulfur content metabolites of TSP are involved in these damage processes. Current research on the transsulfuration pathway in Parkinson’s disease has primarily focused on the synthesis and function of certain metabolites, particularly glutathione. However, our understanding of the regulation of other metabolites of the transsulfuration pathway, as well as their relationships with other metabolites, and their synthesis regulation in Parkinson´s disease remain limited. Thus, this paper highlights the importance of studying the molecular dynamics in different metabolites and enzymes that affect the transsulfuration in Parkinson’s disease.

July 26, 2023

Involvement of microglia in chronic neuropathic pain associated with spinal cord injury – a systematic review

David Ramos, Célia Duarte Cruz

Page range: 933-950

Abstract

In recent decade microglia have been found to have a central role in the development of chronic neuropathic pain after injury to the peripheral nervous system. It is widely accepted that peripheral nerve injury triggers microglial activation in the spinal cord, which contributes to heightened pain sensation and eventually chronic pain states. The contribution of microglia to chronic pain arising after injury to the central nervous system, such as spinal cord injury (SCI), has been less studied, but there is evidence supporting microglial contribution to central neuropathic pain. In this systematic review, we focused on post-SCI microglial activation and how it is linked to emergence and maintenance of chronic neuropathic pain arising after SCI. We found that the number of studies using animal SCI models addressing microglial activity is still small, compared with the ones using peripheral nerve injury models. We have collected 20 studies for full inclusion in this review. Many mechanisms and cellular interactions are yet to be fully understood, although several studies report an increase of density and activity of microglia in the spinal cord, both in the vicinity of the injury and in the spared spinal tissue, as well as in the brain. Changes in microglial activity come with several molecular changes, including expression of receptors and activation of signalling pathways. As with peripheral neuropathic pain, microglia seem to be important players and might become a therapeutic target in the future.

Ahead of Print / Just Accepted

Ahead of Print / Just Accepted

Volume 34 (2023)

Volume 33 (2022)

Volume 32 (2021)

Volume 31 (2020)

Volume 30 (2019)

Volume 29 (2018)

Volume 28 (2017)

Volume 27 (2016)

Volume 26 (2015)

Volume 25 (2014)

Volume 24 (2013)

Volume 23 (2012)

Volume 22 (2011)

Volume 21 (2010)

Volume 20 (2009)

Volume 19 (2008)

Volume 18 (2007)

Volume 17 (2006)

Volume 16 (2005)

Volume 15 (2004)

Volume 14 (2003)

Volume 13 (2002)

Volume 12 (2001)

Volume 11 (2000)

Volume 10 (1999)

Volume 9 (1998)

Volume 8 (1997)

Volume 7 (1996)

Volume 6 (1995)

Volume 5 (1994)

Volume 4 (1993)

Volume 3 (1992)

Volume 2 (1990)

Volume 1 (1987)

Issue 3-4

Journal Impact Factor	4.1	2022, Journal Citation Reports (Clarivate, 2023)
5-year Journal Impact Factor	4.7	2022, Journal Citation Reports (Clarivate, 2023)
Journal Citation Indicator	0.94	2022, Journal Citation Reports (Clarivate, 2023)
CiteScore	8.1	2022, Scopus (Elsevier B.V., 2023)
SCImago Journal Rank	1.074	2022, SJR (Scimago Lab, 2023; Data Source: Scopus)
Source Normalized Impact per Paper	1.091	2022, CWTS Journal Indicators (CWTS B.V., 2023; Data Source: Scopus)

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Editorial

Editor-in-Chief

Joseph P. Huston (Düsseldorf, Germany)

Associate Editor

Bianca Topic (Düsseldorf, Germany)

Editorial Board

Hojjat Adeli (Columbus, USA)
Gyorgy Buzsaki (New York, USA)
Jacqueline N. Crawley (Bethesda, USA)
Tim J. Crow (Headington, UK)
Paul E. Gold (Champaign, USA)
Florian Holsboer (Munich, Germany)
Carsten Korth (Düsseldorf, Germany)
Jay-Shake Li (Chiayi, Taiwan)
Gerd Lubec (Vienna, Austria)
Claudia Mattern (Emmetten, Switzerland)
Bruce S. McEwen (New York, USA)
Weihong Pan (Baton Rouge, USA)
Mikhail Pletnikov (Baltimore, USA)
Trevor W. Robbins (Cambridge, UK)
Alfons Schnitzler (Düsseldorf, Germany)
Oswald Steward (Irvine, USA)

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de Gruyter
Genthiner Str. 13
D-10785 Berlin
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Tel. 0049-30-26005176
Fax 0049-30-26005352
e-mail: rev.neurosci.editorial@degruyter.com

(Deutsch)

Online ISSN: 2191-0200
Print ISSN: 0334-1763
Type: Journal
Language: English
Publisher: De Gruyter
First published: April 1, 1987
Publication Frequency: 8 Issues per Year
Audience: Neuroscientists, Psychiatrists, Psychologists, Life Scientists, Pharmacologists, Biologists