Intersemiotic projection is one of the most common configurations in the knowledge construction process of academic comics. Although previous studies address some general features of intersemiotic projection, further research on interdependency relations of intersemiotic projection is needed in order to map out the whole system. This study, based on the social-semiotic approach to multimodal studies, proposes a systemic framework of image-text paratactic and hypotactic projection in academic comics. This framework identifies three sub-categories of paratactic projection and hypotactic projection, respectively: (1) Emergent, (2) Adjoined, (3) Sequential, (4) Compound, (5) Subsumed, and (6) Fused. The use of these projection configurations contributes to the realization of the communicative purposes of academic comics to evidence, exemplify, emphasize, explain, elaborate, and visualize the discussed knowledge. This research attempts not only to contribute to the theoretical development of multimodality from the social-semiotic perspective by refining and enlarging the multimodal hypotactic projection framework but also to provide an effective and applicable tool for comics analysis.