The localization of baroreceptive fibers in the vagal nerve and their selective stimulation are key requirements to establish vagus nerve stimulation as an alternative therapy for patients suffering from therapy refractory hypertension. The selectivity of this stimulation is therefore essential as a non-selective stimulation of the entire vagus causes cardial and gastrointestinal side effects, which are unacceptable for chronic therapy. Through the use of multichannel-polyimide thinfilm cuff electrodes, it is possible to locate and selectively stimulate these baroreceptive fibers. The signals recorded are in realtime correlated to ECG and blood pressure signals to identify those electrodes which are closest to the baroreceptive fibers. The algorithm developed for this purpose is based on the coherent averaging and requires no constant electrode-tissue impedance. Electrodes found proximal to the baroreceptive fibers are used as tri- or pentapolar stimulation electrodes. Selective stimulation over these electrodes results in activation of the baroreflex decreasing the blood pressure while simultaneousely avoiding any significant bradycardia.