Open Access Published by De Gruyter Open Access

Volume 13 Issue 1

January 2022

Issue of Translational Neuroscience

Submit manuscript

Contents
Journal Overview

Successful recognition has been known to produce distinct patterns of neural activity. Many studies have used spectral power or event-related potentials of single recognition-specific regions as classification features. However, this does not accurately reflect the mechanisms behind recognition, in that recognition requires multiple brain regions to work together. Hence, classification accuracy of subsequent memory performance could be improved by using functional connectivity within memory-related brain networks instead of using local brain activity as classifiers. In this study, we examined electroencephalography (EEG) signals while performing a word recognition memory task. Recorded EEG signals were collected using a 32-channel cap. Connectivity measures related to the left hemispheric fronto-parietal connectivity (P3 and F3) were found to contribute to the accurate recognition of previously studied memory items. Classification of subsequent memory outcome using connectivity features revealed that the classifier with support vector machine achieved the highest classification accuracy of 86.79 ± 5.93% (mean ± standard deviation) by using theta (3–8 Hz) connectivity during successful recognition trials. The results strongly suggest that highly accurate classification of subsequent memory outcome can be achieved by using single-trial functional connectivity.

Approximately 6.8 million people die annually because of problems related to the central nervous system (CNS), and out of them, approximately 1 million people are affected by neurodegenerative diseases that include Alzheimer’s disease, multiple sclerosis, epilepsy, and Parkinson’s disease. CNS problems are a primary concern because of the complexity of the brain. There are various drugs available to treat CNS disorders and overcome problems with toxicity, specificity, and delivery. Barriers like the blood–brain barrier (BBB) are a challenge, as they do not allow therapeutic drugs to cross and reach their target. Researchers have been searching for ways to allow drugs to pass through the BBB and reach the target sites. These problems highlight the need of nanotechnology to alter or manipulate various processes at the cellular level to achieve the desired attributes. Due to their nanosize, nanoparticles are able to pass through the BBB and are an effective alternative to drug administration and other approaches. Nanotechnology has the potential to improve treatment and diagnostic techniques for CNS disorders and facilitate effective drug transfer. With the aid of nanoengineering, drugs could be modified to perform functions like transference across the BBB, altering signaling pathways, targeting specific cells, effective gene transfer, and promoting regeneration and preservation of nerve cells. The involvement of a nanocarrier framework inside the delivery of several neurotherapeutic agents used in the treatment of neurological diseases is reviewed in this study.

Fengyue Han, Dan Su, Chuanqiang Qu

Page range: 70-70

Download PDF

Open Access September 6, 2022

Erratum to “Construction and effect evaluation of different sciatic nerve injury models in rats”

Siwei Qu, Ning Ma, Weixin Wang, Sen Chen, Qi Wu, Yangqun Li, Zhe Yang

Page range: 291-291

Download PDF

Retraction

Open Access April 20, 2022

Nervonic acid amends motor disorder in a mouse model of Parkinson’s disease

Dandong Hu, Yujuan Cui, Ji Zhang

Page range: 71-71

Download PDF

Open Access November 17, 2022

Retraction of “Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling”

Jiang Cheng, Guowei Wang, Na Zhang, Fang Li, Lina Shi, Haining Li

Page range: 407-407

Download PDF

About this journal

Why subscribe and read

Premier source of high quality research; Reports novel findings that are likely to change the direction of thinking and practice in biomedical sciences; Covers research findings in all subfields of neuroscience (behavioral, cognitive, computational, developmental and regeneration, molecular, neural aging, neuroanatomy, neurobiology, neurochemistry, neuroendocrinology, neurogenetics, neuroimmunology, neuropathology, neuropharmacology, neurophysiology, methodology, neurotoxicology and systems neuroscience) as well as in the fields of neurology, neurosurgery and psychiatry; Represents international forum for the dissemination of research data aiming at the exchange of ideas thus facilitating the collaboration between researchers from different countries.

Why submit

Unbiased, fast and comprehensive peer review; Web-based manuscript submission system; Free English language correction of grammar and style for authors.

Volume 13 Issue 1

Issue of Translational Neuroscience

Mice can recognise water depths and will avoid entering deep water

Abstract

CLSPCOL rescues Alzheimer’s disease mouse models

Abstract

Ischemic stroke following STA–MCA double bypass

Abstract

Relationship between subclasses low-density lipoprotein and carotid plaque

Abstract

Construction and effect evaluation of different sciatic nerve injury models in rats

Abstract

Effects of propofol on neuroblastoma cells via the HOTAIRM1/miR-519a-3p axis

Abstract

Effects of Goldblatt hypertension on rats’ hippocampal cholinergic system

Abstract

Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model

Abstract

Molecular recognition of the interaction between ApoE and the TREM2 protein

Abstract

Remimazolam induced cognitive dysfunction in mice via glutamate excitotoxicity

Abstract

Hybrid 18F-florbetapir PET/MRI for assessing myelin recovery in GFAP-A patients

Abstract

Preliminary study on pathogenic mechanism of first Chinese family with PNKD

Abstract

Aged rats learn Morris Water maze using non-spatial search strategies evidenced by a parameter-based algorithm

Abstract

Embelin and levodopa combination therapy for improved Parkinson’s disease treatment

Abstract

The roles and diagnostic value of miRNA-1246 in the serum of patients with intracranial aneurysms

Abstract

Predictors of high dose of massed practice following stroke

Abstract

The effect of stimulation frequency on transcranial evoked potentials

Abstract

Increased levels of neurofilament light chain in suicide attempters’ serum

Abstract

Propofol ameliorates ischemic brain injury by blocking TLR4 pathway in mice

Abstract

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease

Abstract

Psychobiotics improve propionic acid-induced neuroinflammation in juvenile rats, rodent model of autism

Abstract

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway

Abstract

Ketamine alleviating depressive-like behaviors is associated with regulation of nNOS–CAPON–Dexras1 complex in chronic unpredictable mild stress rats

Abstract

The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

Abstract

Outcomes of acute ischemic stroke in kidney transplant recipients: An analysis of US Nationwide inpatient sample

Abstract

Brain atrophy pattern in patients with mild cognitive impairment: MRI study

Abstract

Correlation of serum RBP4 level with oxidative stress and unstable carotid plaque in patients with cerebral infarction

Abstract

Prevalence of neurodegenerative/demyelinating disorders in patients with achalasia

Abstract

Protection against H2O2-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway

Abstract

Alteration in NMDAR subunits in different brain regions of chronic unpredictable mild stress (CUMS) rat model

Abstract

Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway

Abstract

Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort

Abstract

Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex

Abstract

Mild acute stress prevents the memory impairment induced by long-term isoflurane anesthesia

Abstract

Esketamine improves propofol-induced brain injury and cognitive impairment in rats

Abstract

Correlations between EEG and intestinal electrical stimulation

Abstract

Factors influencing recovery of upper limb motor function during constraint-induced movement therapy for people with stroke

Abstract

Application of auditory mismatch negativity in tinnitus patients based on high-resolution electroencephalogram signals

Abstract

The value of transcranial Doppler monitoring of cerebral blood flow changes during carotid endarterectomy performed under regional anesthesia – A case series

Abstract

Hybrid ¹⁸F-florbetapir PET/MRI for assessing myelin recovery in GFAP-A patients

Protection against H₂O₂-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway