A simple, fast, efficient, and reagent free procedure without any chemical pretreatment has developed for simultaneous analysis of sodium lauryl ether sulfate (SLES), ethanol and isopropanol in some commercial cleaners. This determination was carried out using attenuated total reflectance Fourier transform infrared spectrometry (ATR-FTIR) and multivariate analysis. Partial least-squares (PLS) statistical method for quantitative analysis was used to determine the spectra of three components in a mixture of liquid household detergents. The statistical parameters such as Root Mean Square Error of Calibration (RMSEC), Root Mean Square Error of Cross Validation (RMSECV), Standard Errors of Prediction (SEP) and square correlation coefficient (R 2 ) were obtained 0.07, 0.18, 0.16 (v/v%), 0.15, 0.32, 0.69 (v/v%), 0.22, 0.34, 0.57 (v/v%) and 0.9995, 0.9996 and 0.9998 for SLES, isopropanol and ethanol respectively. Good agreements were achieved between our results and the reference and standard values.