In this paper, we investigate the steady boundary layer flow of a non-Newtonian fluid, represented by a Sisko fluid, over a wedge in a moving fluid. The equations of motion are derived for boundary layer flow of an incompressible Sisko fluid using appropriate similarity variables. The governing equations are reduced to a single third-order highly nonlinear ordinary differential equation in the dimensionless stream function, which is then solved analytically using the homotopy analysis method. Some important parameters have been discussed by this study, which include the power law index n, the material parameter A, the wedge shape factor b, and the skin friction coefficient Cf. A comprehensive study is made between the results of the Sisko and the power-law fluids.