β -Ionone and camphor were ethynylated to give the alkynols 14 , 16 , 17 which can be transformed to the alkynolethers 5b , 5i , 5j , 5k , 5l , 5m by treatment with dimethylsulfate and chlorotrimethylsilane, respectively. From the alkynolethers 5h , 5i , 5j / 5k , 5l / 5m the orthoamide derivatives 4h , 4i , 4j / 4k , 4l / 4m can be prepared by treatment with N,N,N ′ ,N ′ ,N ″ ,N ″-hexamethylguanidinium chloride ( 8 ) in the presence of sodium hydride. The orthoamides 4h , 4i react with the sulfonamide 30 under condensation yielding the N -sulfonylated acrylamidines 31 , 32 . From the orthoamide 4h and p -nitroaniline the propiolamidine 29 could be obtained. The orthoamides 4j / 4k and 4l / 4m , react with benzamidine to give the pyrimidines 33 , 34 , respectively. In the reaction of malonodinitrile ( 9a ) with the orthoamides 4i and 4j / 4k , mixtures of 1,1-diamino-1,3-butadienes 36 , 38 and 1,3-diamino-1,3-butadienes 37 and 39 are produced, respectively. From CH 2 -acidic compounds as ethylcyanacetate ( 9b ), diethyl-malonate ( 9c ) and nitromethane ( 9d ) and the orthoamide 4i the 1,1-diamino-1,3-butadienes 36b – d were produced. The pyridone derivative 40 can be prepared from cyanoacetamide ( 9e ) and the orthoamide 4i . The condensation of the orthoamides 4j / 4k with cyanoacetamide ( 9e ) affords a mixture of the pyrimidone 41 and the nicotinonitrile 42 .