By nonenzymatic model reactions, the influence of vanadium (VO 2+ , VO 3 − ) and other metal ions (Al 3+ , Fe 2+ , Fe 3+ , Zn 2+ , Ni 2+ , Cr 3+ ) on the transamination of 4,5-dioxovaleric acid (DOVA) with ʟ-alanine (Ala) to δ -aminolevulinic acid (δ-ALA) and pyruvic acid (PA) with pyridoxal phosphate (PLP) is investigated. The examinations of the partial reactions show that VO 2+ , VO 3 − and Fe 2+ effectively enhance both conversions, while Ni 2+ only promotes the conversion of DOVA to δ -ALA with pyridoxamine phosphate (PMP). Besides Cr 3+ , which inhibits the transaminations, all other metals tried slightly enhance both reactions. The coupled transamination DOVA/Ala to δ-ALA/PA with PLP as a catalyst is performed at 40 °C , the extent of the reaction being judged by the amount of δ-ALA formed. Among all metal ions tested, VO 2+ and VO 3 − were found to be the most effective ones. Fe 2+ , Al 3+ and Fe 3+ also slightly enhance the reaction, but all other metals do not influence or inhibit the transamination. In presence of VO 2+ or VO 3 − ions, the optimum pH of the reaction shifts from pH 4 to pH 7.4. The positive influence of vanadium on δ-ALA transamination is discussed in connection with known structures of analogous Schiff base complexes with metal ions.