journal: Zeitschrift für Naturforschung C

Impact Factor: 2.0

Veröffentlicht seit 20. Februar 1973

Zeitschrift für Naturforschung C

A Journal of Biosciences

ISSN: 1865-7125

Editor-in-Chief: Jürgen Seibel

Wissenschaftlicher Beirat: Achim Aigner, Wilhelm Boland, Uwe Bornscheuer, Klaus Hoffmann

Manuskript einreichen

Über diese Zeitschrift

Objective

A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products.

The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products.

A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.

Topics

Bio-chemical synthesis and bioactivities of natural products
Isolation (including structure elucidation)
Biochemistry
Biotechnology
Pharmacology
Chemistry
Biology

Article formats

Original research articles, research notes, letters and review articles

Please have a look at the call for papers for two upcoming Special Issues:

Special Issue on CAZymes

Special Issue on Chitin Structures and Pathways as Targets for Biopesticides and Drugs

Ihre Vorteile

Zeitschrift für Naturforschung C – A Journal of Biosciences is proud to announce a new feature, the Editor’s Choice free access article. To download the featured article free of charge, please click the link below.

Vol. 76, Iss. 3-4: Design and synthesis of novel n-butyphthalide derivatives as promising botanical fungicides by Zhongfu Luo, Yu Deng, Bilan Luo, Yong Li, Qing Lan, Judi Fan, Wei Xue, Lei Tang and Lingling Fan

Vol. 76, Iss. 3-4: Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor by Nursenem Karaca, Görkem Şener, Betül Demirci and Fatih Demirci

Vol. 76, Iss. 1-2: Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the essential oils from Piper arboreum Aubl., Piper aduncum L. e Piper gaudichaudianum Kunth by Ana Cristina A. da Silva, Edinardo F. F. Matias, Janaína E. Rocha, Ana Carolina Justino de Araújo, Thiago S. de Freitas, Fábia F. Campina, Maria do S. Costa, Luiz E. Silva, Wanderlei do Amaral, Beatriz Helena L. N. S. Maia, Aurea P. Ferriani, Camila F. Bezerra, Marcello Iriti and Henrique D. M. Coutinho

Vol. 76, Iss. 1-2: Ethyl acetate extract from Cistus x incanus L. leaves enriched in myricetin and quercetin derivatives, inhibits inflammatory mediators and activates Nrf2/HO-1 pathway in LPS-stimulated RAW 264.7 macrophages by Mario D’Ambrosio, Elisabetta Bigagli, Lorenzo Cinci, Antonella Gori, Cecilia Brunetti, Francesco Ferrini and Cristina Luceri

Vol. 75, Iss. 11-12: Modulation of antibiotic resistance by the essential oil of Ocimum gratissimum L. in association with light-emitting diodes (LED) lights by Maria Karollyna do N. Silva Leandro, Janaína E. Rocha, Camila F. Bezerra, Priscilla R. Freitas, Jessica Horana F. Feitosa, Viviane B. Bezerra, Rizelle de O. Barros, Livia Maria G. Leandro, José Junior dos S. Aguiar, Paulo S. Pereira, Marcela Christofoli, Jaime Ribeiro-Filho, Marcello Iriti, Henrique Douglas M. Coutinho and Edinardo Fagner F. Matias

Vol. 78, Iss. 3-4: Special Issue on Organic Chemistry and Medicinal Applications

Vol. 75, Iss. 7-8: Special Issue on Essential Oils

Vol. 74, Iss. 9-10: Special Section on Chemistry of Social Insects

Vol. 74, Iss. 3-4: Special Issue on Chemo-enzymatic cascade reactions

Vol. 72, Iss. 9-10: Special Issue on Insect Biotechnology

Vol. 72, Iss. 7-8: The Special Section is dedicated to the memory of Professor Lothar Jaenicke

Vol. 71, Iss. 9-10: The issue is dedicated to the memory of Professor Peter Böger

Your Benefits

International outreach of A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC)
Cross-disciplinary contributions from chemistry-biology boundary
Authoritative and recognized reviewers

Geschichte

Alfred Klemm, then working at the Kaiser Wilhelm Institute of Chemistry in Tailfingen, founded the Zeitschrift fuer Naturforschung together with Hans Friedrich-Freksa in 1946. In 1947 the Zeitschrift fuer Naturforschung was divided into two parts which were devoted to the physical sciences (Section A) and the chemical and biological sciences including biophysics (Section B). It was then only in 1973, that Section C was established for the biological sciences while Section B concentrated on chemistry. In Zeitschrift fuer Naturforschung C – A Journal of Biosciences, as it is fully referred to now, research papers are presented in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.

Other publications in the field

Abstracting und Indexing

Zeitschrift für Naturforschung C ist in den folgenden Services indiziert:

AGRICOLA (National Agricultural Library)
Baidu Scholar
Cabells Journalytics
CABI (over 50 subsections)
Chemical Abstracts Service (CAS) - CAplus
Chemical Abstracts Service (CAS) - SciFinder
CNKI Scholar (China National Knowledge Infrastructure)
CNPIEC - cnpLINKer
Dimensions
EBSCO (relevant databases)
EBSCO Discovery Service
EMBASE
Genamics JournalSeek
Google Scholar
Japan Science and Technology Agency (JST)
J-Gate
Journal Citation Reports/Science Edition
JournalGuide
JournalTOCs
KESLI-NDSL (Korean National Discovery for Science Leaders)
Medline
MyScienceWork
Naver Academic
Naviga (Softweco)
Primo Central (ExLibris)
Publons
PubMed
QOAM (Quality Open Access Market)
ReadCube
Reaxys
Scilit
SCImago (SJR)
SCOPUS
Semantic Scholar
Sherpa/RoMEO
Summon (ProQuest)
TDNet
Ulrich's Periodicals Directory/ulrichsweb
WanFang Data
Web of Science - Biological Abstracts
Web of Science - BIOSIS Previews
Web of Science - Current Contents/Life Sciences
Web of Science - Science Citation Index
Web of Science - Science Citation Index Expanded
WorldCat (OCLC)
X-MOL
Yewno Discover

Zusatzmaterial

Fachgebiete

Externe Links

Online Submission of Manuscripts

Band 78 Heft 11-12

November 2023

Öffentlich zugänglich 23. November 2023

Frontmatter

Seiten: i-iii

PDF downloaden

Research Articles

24. August 2023

Crystal structure of phloridzin and its distribution changes in flowering and fruiting stage of Malus rockii

Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao

Seiten: 383-387

Mehr

Abstract

The exact structure of phloridzin was further confirmed as phloretin 6′- O -glucopyranoside by a single-crystal X-ray diffraction experiment. The distribution changes of phloridzin in flowering, fruitlet, and fruit ripening phases of Malus rockii were quantified by an HPLC with an external standard. The concentrations of phloridzin in leaves, twigs, and bark and xylem of twigs increased at first and then decreased, and reached the highest value in the fruitlet period. The highest concentration of phloridzin was found in leaves, with the percentage contents of 10.92–14.43 %. What is more, the decreased value of the concentration of phloridzin in leaves from fruit ripening period was almost equivalent to the increased value of the concentration of phloretin. This interesting physiological phenomenon should be able to provide the readers, especially plant physiologists, with a new perspective for the development and utilization of phloridzin.

11. September 2023

Evaluation of maceration, microwave, ultrasound-assisted extraction methods on free, esterified and bound phenolic profile and antioxidant activity of black rice

Md. Latifur Rahman, Subhajit Mandal, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu

Seiten: 389-398

Mehr

Abstract

Black rice ( Oryza sativa L.) is a rich source of phenolics and anthocyanins. It was aimed to investigate the effect of different extraction methods such as conventional solvent extraction, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE) on antioxidant activity and phenolic profiling of black rice free, esterified, and bound phenolics fractions. Spectrophotometric methods were used to evaluate antioxidant activity and HPTLC was used for phenolics profiling. The highest content of % yield, total anthocyanin (TAC), total phenolic (TPC), and total flavonoid (TFC) contents were detected in MAE. It was also observed that antioxidant activity based on DPPH, ABTS, superoxide radical-scavenging and ferric reducing antioxidant power (FRAP) assays showed highest activity in MAE. Eight phenolic compounds were identified and quantified by a validated HPTLC method. MAE showed most abundant phenolic compounds. A significant positive correlation was established between % yield, total phenolic content, and total flavonoid content ( p < 0.05) where a significant negative correlation was established between % yield, TPC, and TFC with IC 50 of antioxidant activity ( p < 0.05). Diverse phenolic contents and antioxidant activity were studied with different forms of phenolics with the different extraction methods. It designates that the extraction techniques had effects on the bioactive compounds as well biological properties.

14. September 2023

Dietary flavonoid myricetin 3-O-galactoside suppresses α-melanocyte stimulating hormone-induced melanogenesis in B16F10 melanoma cells by regulating PKA and ERK1/2 activation

Jung Hwan Oh, Fatih Karadeniz, Youngwan Seo, Chang-Suk Kong

Seiten: 399-407

Mehr

Abstract

Melanogenesis is the process where skin pigment melanin is produced through tyrosinase activity. Overproduction of melanin causes skin disorders such as freckles, spots, and hyperpigmentation. Myricetin 3- O -galactoside (M3G) is a dietary flavonoid with reported bioactivities. M3G was isolated from Limonium tetragonum and its anti-melanogenic properties were investigated in α-melanocyte stimulating hormone-stimulated B16F10 melanoma cells. The in vitro anti-melanogenic capacity of M3G was confirmed by inhibited tyrosinase and melanin production. M3G-mediated suppression of melanogenic proteins, tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (TRP)-1 and TRP-2, were confirmed by mRNA and protein levels, analyzed by RT-qPCR and Western blot, respectively. Furthermore, M3G suppressed Wnt signaling through the inhibition of PKA phosphorylation. M3G also suppressed the consequent phosphorylation of CREB and nuclear levels of MITF. Analysis of MAPK activation further revealed that M3G increased the activation of ERK1/2 while p38 and JNK activation remained unaffected. Results showed that M3G suppressed melanogenesis in B16F10 cells by decreasing tyrosinase production and therefore inhibiting melanin formation. A possible action mechanism was the suppression of CREB activation and upregulation of ERK phosphorylation which might cause the decreased nuclear levels of MITF. In conclusion, M3G was suggested to be a potential nutraceutical with anti-melanogenic properties.

13. September 2023

A new alkaloid from Portulaca oleracea L. with its anti-inflammatory activity

Junjie Yao, Lina Wang, Peishan Liu, Mingyang Song, Jiayin Tian, Fan He, Xixiang Ying

Seiten: 409-413

Mehr

Abstract

A new isoindole alkaloid, 6-hydroxy-2-(4′′′-hydroxy-3′′′-methoxyphenethyl)-4-(4′-hydroxy-3′-methoxyphenyl)-7-methoxy-1 H -benzo[f]isoindole-1,3(2 H )-dione, named oleraisoindole B was isolated from Portulaca oleracea L., its structure was elucidated using NMR and UHPLC-ESI-Q-TOF/MS spectroscopic methods, and presented anti-inflammatory activity at 5 μM.

27. September 2023

Terpenoid compounds from the fruits of Solanum virginianum

Yan Liu, Shuang Liu, Zhen-Peng Xu, Si-Yi Wang, Yi-Kai Jiang, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yang

Seiten: 415-420

Mehr

Abstract

Eleven compounds were isolated and identified from ethanolic extracts of Solanum virginianum fruits, including two new compounds ( 1 – 2 ) and nine known compounds ( 3 – 11 ). Their structures were determined to be melongenaterpene C15- O - β -D-glucopyranoside ( 1 ), (9 Z )-3,7,11,15-tetramethyl -hexadeca-1,6,10-triene-3,5,14,15-tetraol-5- O - β -D-glucopyranoside ( 2 ), actini-dioionoside A ( 3 ), byzantionoside B ( 4 ), citroside A ( 5 ), 7Z-roseoside ( 6 ), matenoside A ( 7 ), megastigmane ( 8 ), dihydrophaseic acid 3′- O - β -D-glucopyranoside ( 9 ), taraxerol ( 10 ), and huzhangoside C ( 11 ). In this paper, NMR spectroscopy was used to study the structures of the compounds, comparing their data with those in the literature. In addition, the potential anti-inflammatory activity of the compounds was also evaluated using the RAW264.7 cell inflammation model induced by lipopolysaccharide (LPS). The terpenoids showed no significant anti-inflammatory activity.

6. November 2023

Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors

Delal Erzurum, Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Zafer Asım Kaplancıklı

Seiten: 421-432

Mehr

Abstract

Carbonic anhydrase (CA) enzymes are a common catalytic enzyme in many organisms. Vertebrates and invertebrates have different CA isoforms. Sixteen different isozymes of the α-CA isoform found in vertebrates have been identified so far. The main task of this enzyme is to catalyze the reversible conversion of carbon dioxide into bicarbonate and hydrogen ions in the body. It is widely distributed in many organs and tissues. They are involved in important physiological processes such as pH and CO 2 homeostasis, biosynthetic reactions such as gluconeogenesis, lipogenesis, ureagenesis, bone resorption, calcification, tumorigenicity, and electrolyte secretion. As a result of the literature research, it has been determined that the most effective inhibitor of the carbonic anhydrase enzyme is sulfonamides. The R group in the general molecular structure of R-SO 2 –NH 2 generally consists of aromatic or heteroaromatic ring systems. The sulfonamides interact strongly with the Zn 2+ ions in the active site of the enzyme. In this study, 10 sulfonamide derivatives were synthesized. Analyses of the obtained compounds are evaluated by using 1 H NMR, 13 C NMR and HRMS spectroscopic methods. The inhibition effect of the obtained compounds on the carbonic anhydrase enzyme was investigated by means of in vitro kit method. For the selected compounds, docking studies were performed and the enzyme active sites and binding points were determined. It was revealed that the strongest interaction with CA enzymes (CA-I, CA-II, CA-IX, CA-XII) active sites was observed with the compound 2e .

1. November 2023

Design, synthesis and apoptotic effects of novel benzoxazole compounds

Betül Kaya, Leyla Yurttaş, Gülşen Akalın-Çiftçi, Mehmet Onur Aksoy

Seiten: 433-440

Mehr

Abstract

A series of new benzoxazole-hydrazone and benzoxazole-1,3,4-oxadiazole derivatives have been designed, synthesized and evaluated as cytotoxic agents toward human A549 lung cancer cells. Compounds 3d, 3e, 5b, 5c, 5d and 5e were the most potent compounds with IC 50 values of <3.9, 10.33, 11.6, 5.00, <3.9 and 4.5 μg/mL, respectively, which are higher than reference drug cisplatin (IC 50 = 19.00 μg/mL). The flow cytometry-based apoptosis detection assay was performed to determine their effects on apoptosis in A549 cells. All tested compounds induced apoptosis in A549 cell line.

Corrigendum

6. September 2023

Corrigendum to: Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts

Aysun Yücetepe, Elif Feyza Aydar, Emine Şükran Okudan, Beraat Özçelik, Gökhan Durmaz

Seiten: 441-441

Band 78 (2023)

Band 77 (2022)

Band 76 (2021)

Band 75 (2020)

Band 74 (2019)

Band 73 (2018)

Band 72 (2017)

Band 71 (2016)

Band 70 (2015)

Band 69 (2014)

Band 68 (2013)

Band 67 (2012)

Band 66 (2011)

Band 65 (2010)

Band 64 (2009)

Band 63 (2008)

Band 62 (2007)

Band 61 (2006)

Band 60 (2005)

Band 59 (2004)

Band 58 (2003)

Band 57 (2002)

Band 56 (2001)

Band 55 (2000)

Band 54 (1999)

Band 53 (1998)

Band 52 (1997)

Band 51 (1996)

Band 50 (1995)

Band 49 (1994)

Band 48 (1993)

Band 47 (1992)

Band 46 (1991)

Band 45 (1990)

Band 44 (1989)

Band 43 (1988)

Band 42 (1987)

Band 41 (1986)

Band 40 (1985)

Band 39 (1984)

Band 38 (1983)

Band 37 (1982)

Band 36 (1981)

Band 35 (1980)

Band 34 (1979)

Band 33 (1978)

Band 32 (1977)

Band 31 (1976)

Band 30 (1975)

Band 29 (1974)

Band 28 (1973)

Journal Impact Factor	2.0	2022, Journal Citation Reports (Clarivate, 2023)
5-year Journal Impact Factor	2.0	2022, Journal Citation Reports (Clarivate, 2023)
Journal Citation Indicator	0.47	2022, Journal Citation Reports (Clarivate, 2023)
CiteScore	3.5	2022, Scopus (Elsevier B.V., 2023)
SCImago Journal Rank	0.342	2022, SJR (Scimago Lab, 2023; Data Source: Scopus)
Source Normalized Impact per Paper	0.682	2022, CWTS Journal Indicators (CWTS B.V., 2023; Data Source: Scopus)

Weitere Informationen über Zeitschriftenmetriken

Einreichen

Submission

You can easily submit your manuscript online. Simply go to http://mc.manuscriptcentral.com/znc and you will be guided through the whole peer reviewing and submission process.

Your benefits of publishing with us

Easy-to-use online submission, peer review, and publication system
Accepted papers will be published online first as DOI-citable, forward-linked articles for quickest possible visibility for the scientific community
High quality manuscript processing through ScholarOne Manuscripts®. Submit your research online at http://mc.manuscriptcentral.com/znc
Single-blind peer-review
Free color figures both in print and online editions
No publication fee
Optional open access publication
Accepted papers will be published online first as DOI-citable, forward-linked articles for quickest possible visibility for the scientific community
Every article easily discoverable because of Search Engine Optimization (SEO) and comprehensive abstracting and indexing services
Secure archiving by De Gruyter and the independent archiving service Portico
Professional sales and marketing activities

Submission process

Submission of your paper via our submission management tool following the Instructions for Authors (you will be guided through every step of the submission process)
Manuscript submissions are approved by the Editor, and, if found suitable for further consideration, peer reviewed by independent expert referees
Single-blind peer review process
Accepted articles are published online ahead of print approx. 4 weeks after acceptance

Please note

Manuscripts must be written in clear and concise English
Proposals of review articles are welcome. A brief outline of the review article and the senior author's CV should be sent to the ZNC editorial office
Before submitting your article please have a look at the Publication Ethics Statement and our Copyright Transfer Agreement
Once your article is accepted you have the option to publish it open access
Our Repository Policy allows you to distribute 30 PDF copies of your published article to colleagues (the PDF has to include the information that it is an author's copy). Please also feel free to distribute the link to the online abstract
If you have any general questions please visit our FAQ page for authors
For more detailed information please contact the ZNC Editorial Office znc@degruyter.com

We look forward to receiving your manuscript!

Hybrid Open Access

In this journal, authors have the option to publish their article under an open access license. Open Access allows you as an author to retain copyright and share your findings with colleagues and interested parties worldwide without any restraints.
Please note that authors from institutions with which we have a transformative agreement can publish open access without paying an article processing charge (APC). More information on the eligible institutions and articles can be found under the "Funding and Support" tab here.

Editorial

Editor in Chief
J. Seibel, Würzburg

Advisory Board
A. Aigner, Leipzig
W. Boland, Jena
U. Bornscheuer, Greifswald
K. H. Hoffmann, Bayreuth

Editorial Board
D. Berkowitz, Lincoln, USA
H. Budzikiewicz, Köln
B. Dräger, Leipzig
M. González-Teuber, Santiago, Chile
J.-K. Liu, Wuhan, China
T. Opatz, Mainz
E. Rösch, Pforzheim
K.-D. Spindler, Ulm
D. Strack, Halle

Editorial Office
Dagmara Magryta, De Gruyter
Email: znc [at] degruyter.com

(English)

Online ISSN: 1865-7125
Print ISSN: 0939-5075
Typ: Zeitschrift
Sprache: Englisch
Verlag: De Gruyter
Erstveröffentlichung: 20. Februar 1973
Erscheinungsweise: 12 Hefte pro Jahr
Zielgruppe: Readership: Academics and practitioners interested in the topic of ZNC