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  • Author: Guo Yi-Sheng x
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C21H17N3O3, orthorhombic, Pbca (no. 61), a = 14.3606(4) Å, b = 7.4250(2) Å, c = 34.2840(9) Å, V = 3655.62(17) Å3, Z = 8, R gt(F) = 0.0399, wR ref(F 2) = 0.1178, T = 571(2) K.

By means of the standard truncated Painlevé expansion and a special Bäcklund transformation, some exact multisoliton solutions are derived for the Kadomtsev-Petviashvili equation. The evolution properties of the multisoliton excitations are investigated and some novel features or interesting behaviors are revealed. The results show that four straight-line solitons are annihilated or produced with the time increases, which is very similar to the completely nonelastic collision among electrons and positrons.


In order to explore the influence of unburned pulverized coal on gasification reaction of coke in blast furnace, kinetic rules of gasification reaction between CO2 and coke powder adding pulverized coals with different volatiles were studied by thermogravimetric analysis. The results showed that weight-loss ratio of samples reacted with CO2 increased after adding pulverized coal, and the weight-loss ratio rose with the increase of coal’s addition. When the content of pulverized coal was up to 50%, the weight-loss ratio of the sample which adding pulverized coal with high volatile was higher under the same temperature. The activation energy about C-CO2 gasification reaction of samples reduced observably after adding pulverized coal. The activation energy of samples had a largest decrease with 83.408 kJ mol−1 at the range of 1223 K~1373 K and it was 28.97 kJ mol−1 at the range of 1373 K~1523 K. The addition of pulverized coal with high volatile can reduce the reaction activation energy of samples more effectively. In the soft melting zone, the gasification reaction model of coke blocks attached the unburned pulverized coal was up to unreacted core model and porous volume-reacted model jointly.


Objective Genome-wide association studies (GWAS) have linked many single nucleotide polymorphisms (SNPs) to the outcomes of a variety of liver diseases. The aim of the present study was to evaluate the association of several candidate SNPs with the risk and severity of cirrhosis due to chronic hepatitis B in a Chinese population.

Methods A total of 714 Chinese participants with persistent HBV infection were studied. Patients were divided into cirrhotic (n = 429) and non-cirrhotic (n = 285) groups based on clinical and pathological evidence. The progression rate and severity of liver cirrhosis were evaluated with an arbitrary t-score system. Genotypes of six SNPs in five candidate genes were detected with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The genotypic distributions of the SNPs were compared between the age-matched cirrhotic and non-cirrhotic subjects. The association between the risk of SNPs and the severity and progression rate of cirrhosis was further analyzed.

Results Rs2679757 polymorphism of the antizyme inhibitor 1 (AZIN1) gene and Rs886277 in the transient receptor potential cation channel subfamily M, member 5 gene (TRPM5) were found to be associated with cirrhosis risk in CHB. They were also correlated with the overall severity and progression rate of cirrhosis. Genotype frequencies of other SNPs were not different between the cirrhosis and non-cirrhosis groups.

Conclusions AZIN1 rs2679757 and TRPM5 rs886277 are associated with the risk and the progression rate of HBV-related liver fibrosis in Chinese patients. The emerging SNPs associated with cirrhosis prognosis warrant further clinical validation in other CHB cohorts or ethnic groups, and merit mechanistic studies to reveal their roles in fibrosis progression.

Objective To evaluate the efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial.

Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n = 220) or combined with TCM (Reduning or Xiyanping injections) (n = 232). The primary outcome was the incidence rate of rash/herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days.

Results The rash/herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and 67.2% (156/232) in TCM and Western medicine combined therapy group, with significant difference (P < 0.001). Moreover, TCM remarkably increased the incidence rate of secondary disappearance, which was 56.4% in Western medicine therapy group and 71.4% in TCM and Western medicine combined therapy group (P = 0.001). No drug-related adverse events were observed.

Conclusions It’s suggested that the integrative TCM and Western medicine therapy achieved a better therapeutic efficacy. TCM may become an important complementary therapy on relieving the symptoms of HFMD.



To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB).


A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong University. The clinical parameters and PTB incidence were compared between HBV carriers and non-HBV subjects. For the meta-analysis, we searched the PubMed, Ovid and Cochrane Library databases for studies comparing PTB incidence between individuals with chronic HBV infection and non-HBV subjects.


HBV carriers were slightly older and had slightly higher ALT levels within normal limits. The body mass index, education and history of pregnancy between HBV carrier and non-HBV groups were comparable. PTB incidence was not associated with HBV carrier status [relative risk (RR) 0.98, 95% confidence interval (CI) 0.71–1.37] in our cohort. However, the meta-analysis involving eight published studies and our study revealed a significant association between chronic HBV infection and PTB incidence (pooled RR 1.26, 95% CI 1.19–1.33).


While maternal HBV carriers did not have a higher incidence of PTB in our cohort, the meta-analysis indicates that individuals with chronic HBV infection appeared to be at risk of PTB as a whole.


C19H17BrN2O2, triclinic, P1̅ (no. 2), a = 8.3979(11) Å, b = 10.4083(14) Å, c = 11.1696(15) Å, α = 69.270(2)°, β = 89.401(2)°, γ = 73.709(2)°, V = 872.1(2) Å3, Z = 2, R gt(F) = 0.0422, wR ref(F 2) = 0.1138, T = 296.15 K.