In this article, a mathematical model was developed for the numerical simulation of the water diffusion in an infinite cylinder. A solver for the diffusion equation was created using the finite volume method, with a fully implicit formulation. In order to create such solver, it was assumed that the boundary condition of the first type is adequate to simulate the physical problem. The solver presupposes variable thermophysical properties and radius in the domain. In order to determine the parameters of the expression between the diffusivity and the moisture content, an optimizer was created, based on the inverse method. The developed mathematical model was applied to simulate the drying of banana and rough rice, using experimental data obtained from the literature. The results obtained in this article, considering the variable diffusivity, are better than the results obtained originally in the literature, where the water diffusivity was considered constant.
Over the past decade, a handful of evidence
has been provided that nonsteroidal anti-inflammatory
drugs (NSAIDs) display effects on the homeostasis of
the endoplasmic reticulum (ER). Their uptake into cells
will eventually lead to activation or inhibition of key
molecules that mediate ER stress responses, raising not
only a growing interest for a pharmacological target in
ER stress responses but also important questions how
the ER-stress mediated effects induced by NSAIDs could
be therapeutically advantageous or not. We review here
the toxicity effects and therapeutic applications of NSAIDs
involving the three majors ER stress arms namely PERK,
IRE1, and ATF6. First, we provide brief introduction on
the well-established and characterized downstream
events mediated by these ER stress players, followed
by presentation of the NSAIDs compounds and mode of
action, and finally their effects on ER stress response.
NSAIDs present promising drug agents targeting the
components of ER stress in different aspects of cancer
and other diseases, but a better comprehension of the
mechanisms underlying their benefits and harms will
certainly pave the road for several diseases’ therapy.