Simile is generally explained as an explicit comparison between two things, which presupposes they have features or qualities in common – but equally, there must be essential differences too. This paper pursues these differences, and explores ideas of dissimilarity in simile, here considered as a separate device from metaphor. It then looks at implications for text analysis, in particular the role of simile in articulating the experience of the unknown and the new in narrations of travel. Drawing on texts by three 19th-century explorers (Livingstone, Stanley, Kingsley) and contrasting them with fiction (Conrad), I argue that the dissimilarities within similes reveal much, particularly with respect to ideological meanings on the one hand, and the expression of certainty and uncertainty on the other.
Primary nonautoimmune hyperthyroidism is a rare cause of neonatal hyperthyroidism. This results from an activating mutation in the thyrotropin-receptor (TSHR). It can be inherited in an autosomal dominant manner or occur sporadically as a de novo mutation. Affected individuals display a wide phenotype from severe neonatal to mild subclinical hyperthyroidism. We describe a 6-month-old boy with a de novo mutation in the TSHR gene who presented with accelerated growth, enlarging head circumference, tremor and thyrotoxicosis.
Genomic DNA from the patient’s and parents’ peripheral blood leukocytes was extracted. Exons 9 and 10 of the TSHR gene were amplified by PCR and sequenced.
Sequencing exon 10 of the TSHR gene revealed a novel heterozygous missense mutation substituting cytosine to adenine at nucleotide position 1534 in the patient's peripheral blood leukocytes. This leads to a substitution of leucine to methionine at amino acid position 512. The mutation was absent in the parents. In silico modeling by PolyPhen-2 and SIFT predicted the mutation to be deleterious.
The p.Leu512Met mutation (c.1534C>A) of the TSHR gene has not been previously described in germline or somatic mutations. This case presentation highlights the possibility of mild thyrotoxicosis in affected individuals and contributes to the understanding of sporadic non-autoimmune primary hyperthyroidism.
To better understand the performance of bonded, coated, and modified wood, knowledge of how these processes alter the dimensional change and mechanical properties of wood at a given moisture content (MC) are important. These localized influences on earlywood (EW) and latewood (LW) properties are not well understood. In the present study, the influence of chemical treatments by hydroxymethylated resorcinol (HMR) and acetylation on moisture-induced dimensional change and longitudinal modulus of elasticity (MOE) of isolated EW and LW specimens of Loblolly pine (Pinus taeda L.) was evaluated. The dimensional change was not altered by the HMR treatment, whereas acetylation lowered it by ∼50% in EW and LW in both radial and tangential directions. The MOE was not influenced by the two chemical treatments tested. Based on results of swelling, shrinkage, and MOE it can be concluded that chemical treatment does not modify EW selectively compared with LW neither in radial nor in tangential orientation.