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  • Author: Szu-Chin Li x
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Abstract

Background: We investigated the genotypic distribution of Hp del in healthy subjects and cancer patients in Taiwan.

Methods: Blood samples were collected from 244 randomly selected healthy Taiwanese volunteers and 737 patients with various cancers. Samples were analyzed for the haptoglobin (Hp) gene, and the presence of the Hp del allele was determined from genomic DNA by an Hp del-specific polymerase chain reaction (PCR) method. The plasma concentration of Hp was also determined.

Results: The frequency of the Hp del allele was calculated to be 0.029, and was not different between the healthy subjects and patients with cancer. The prevalence of Hp deficiency caused by Hp del homozygosity was estimated to be ∼0.85 in 1000. Fifty-seven subjects were reclassified from homozygous Hp 1 or Hp 2 to Hp 1 /Hp del or Hp 2 /Hp del genotypes. The Hp del allele is not associated with prevalence, severity or stage of any cancer.

Conclusions: Congenital Hp deficiency caused by Hp del homozygosity is a condition present in Taiwan with a relatively high frequency. However, the Hp del variant does not play a role in cancer.

Clin Chem Lab Med 2009;47:745–9.