Hypochlorous acid (HOCl) is a bactericidal compound
formed by activated neutrophils during inflammation.
Overproduction of HOCl causes damage to tissues at
the site of neutrophil accumulation. The deleterious effects
of excessive HOCl formation can be attenuated
using antioxidants. Thiols and thioethers are known to
be very effective HOCl scavengers. In the present
study, the potency of several sulfurcontaining compounds
to protect acetylcholinesterase, glutathione
Stransferase P1-1 (GST P1-1) and α1-antiproteinease
against inactivation by HOCl was determined. Surprisingly,
glutathione disulfide was an effective protector
of acetylcholinesterase against hypochlorous acid.
Glutathione disulfide did not provide protection for
GST P1-1 and α1-antiproteinease against oxidative inactivation
by HOCl. The implications of this finding are discussed.