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  • Author: Zhen Song x
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Abstract

Complex curved surface parts are widely used in important fields such as aerospace, energy and power. In the machining process for the curved features of the parts, the contour-following error of the CNC (computer numerical control) system is increasingly significant due to the existence of servo delay for the feed-drive system and the dynamics mismatch between each axis. Then, the formed contouring error will directly affects the machining quality of the complex curved surface parts. To reduce the contour-following error, this paper presents a cross-coupled controller with tracking-error compensation. First, the tracking error for each feed axis is compensated in real time. On this basis, the numerical efficient contouringerror estimation method is utilized and the proportional cross-coupled controller is integrated with the tracking-error compensator. By using this method, the tracking error and contouring error can be synergistically reduced and the contour accuracy of the CNC system can be dramatically improved. Results of the verification tests demonstrate the feasibility of the presented approach, and the presented approach is significant for high-speed and high-precision machining of complex curved surface parts.

Abstract

This study evaluates the efficacy of pembrolizumab for the treatment of advanced/metastatic melanoma. The literature search was conducted in electronic databases for studies that evaluated the efficacy and safety of pembrolizumab either alone or in combination with other treatments advanced/metastatic melanoma patients. Random-effects meta-analyses were performed to achieve pooled effect sizes of response and survival rates. The overall objective response rate (ORR) was 34.2% [95% confidence interval (CI): 30.4, 38.0]. However, ORR differed with respect to the history of prior systemic therapy. ORR was lower in studies with over 50% patients with prior therapy (25.5% [22.4, 28.5]) than in studies with under 50% patients with prior therapy (40.1% [34.1, 46.1]). ORR was higher in pembrolizumab monotherapy (32.9% [28.1, 37.7]) than in pembrolizumab–ipilimumab combination (27.6% [24.0, 31.2]). Overall ORR was inversely associated with visceral metastasis and prior systemic therapy. With pembrolizumab treatment, either alone or in combination, the progression-free survival (PFS) was 5.73 months; 12-, 24-, and 60-month PFS rate were 44%, 27%, and 25%, respectively; and 12-, 24-, and 60-month overall survival rates were 65%, 50%, and 41%, respectively. The percentage of AEs that led to treatment discontinuation was 13%. Pembrolizumab monotherapy is a valuable option for the treatment of advanced/metastatic melanoma patients.

Addition of anhydrous InCl3 to a THF solution of CuCl and dppe (dppe = Ph2PCH2CH2PPh2), or CuCl and PPh3, resulted in the formation of the crystalline heterometallic copper(I)/indium(III) complexes [(dppeCu)2(μ-Cl)(μ-dppe)][InCl4]·THF (1·THF) and [{Cu(PPh3)2}2(μ-Cl)4(InCl)]·THF (2·THF), respectively, which have been characterized by X-ray diffraction. Compound 1 is composed of a dinuclear copper(I) complex cation and a mononuclear tetrahedral indium(III) complex anion. Complex 2 comprises an indium center in a quasi square-pyramidal chloride-coordination environment connected to two Cu(PPh)3 fragments via Cu(μ-Cl)2 In bridges

Abstract

C37H36N6O2, monoclinic, P21/c (no. 14), a = 9.18664(12) Å, b = 14.50209(16) Å, c = 23.1787(3) Å, β = 94.0829(12)°, Z = 4, V = 3080.16(7) Å3, R gt(F) = 0.0398, wR ref(F 2) = 0.1041, T = 113.5(4) K.

Abstract

2-Aryl-benzothiazoles have been successfully synthesized via a simple coupling reaction between benzothiazoles and aryl sulfamates using a nickel catalyst. The nickel catalyst is inexpensive, reusable and commercially available. In addition, the use of highly expensive palladium catalysts and unstable raw materials has been avoided. 2-Aryl-benzothiazoles bearing various substituents on the aryl groups were obtained in good yield.

Abstract

C16H11CuN3O8, tetragonal, I41/a (no. 88), a = 17.1139(2) Å, c = 25.5803(5) Å, V = 7492.1 Å3, Z = 16, Rgt(F) = 0.0409, wRref(F2) = 0.1261, T = 296 K.

Abstract

C24H22N9NdO17, triclinic, P1̅ (no. 2), a = 7.6445(15) Å, b = 7.9378(16) Å, c = 25.741(5) Å, α = 94.51(3)°, β = 91.76(3)°, γ = 97.34(3)°, V = 1543.1(5) Å3, Z = 2, R gt (F) = 0.0274, wR ref (F 2 ) = 0.0686, T = 290(2) K.

Abstract

Photocatalytic activity by supported TiO2 doping with Graphene oxide and Lanthanum were investigated. The carrier of cenosphere was prepared by using washing, acid-processing and alkali-processing, SEM result shows that the surface of cenosphere is glossy and smooth. Through photocatalytic degradation of methylene blue solution, photocatalytic activities of powder materials after treatment and the influencing factors were compared. The degradation rate of methylene blue by using 0.5% Lanthanum doped TiO2 is better than the other doping amounts. 0.5% GO doped TiO2 has the same rule. 0.5% La and 0.5% GO doping TiO2 were chosen as the optimum condition. SEM and XRD result shows the sol become antase-TiO2 and were coated uniformly in the surface of the carrier. The decoloration rate of the supporter material is about 90% in 60 minutes and it can maintain a very good photocatalytic performance after recycle 20 times. It indicates that the material has a wide application prospect.