To build a vomit-free ward of scientific and standardized management mode, and to evaluate its clinical effects on preventing nausea and vomiting in patients undergoing chemotherapy.
A total of 200 patients suffering from nausea and vomiting were randomly selected from the registration system, from which 120 cases were enrolled according to the inclusion and exclusion criteria. These subjects were divided into control group and observation group (60 patients in each). Both of the two groups received routine nursing care, while the treatment group subjects lived in the vomit-free wards where extra nursing interventions were applied to prevent chemotherapy-induced nausea and vomiting (CINV), with constant observation of the frequency and severity of nausea and vomiting. The outcomes of the subjects from both the groups as well as nurses’ cognition level of CINV were compared after four chemotherapy cycles.
The difference in the scoring for the frequency and severity of nausea and vomiting in two groups was statistically significant (P < 0.05). The scores of nurses’ cognition level of CINV were compared between before and after the interventions, and the difference had statistical significance (P < 0.05).
The management mode aiming to build vomit-free wards could decrease the incidence of CINV in patients during chemotherapy, and at the same time increased the cognitive level of nursing staff toward CINV, which is of great value in clinical practice and is worthy of further application.
Creep properties of four varieties japonica cooked rice were tested using a dynamic mechanical analyzer (DMA Q800). The creep curve was described by Burgers model. The creep process of japonica cooked rice mainly consisted of retarded elastic deformation, ?R and viscous flow deformation, ?V, and negligible instantaneous elastic deformation, ?E. The retarded elastic modulus, ?2, relaxation time, ?, and the viscosity coefficient, ?1, of the cooked rice according to the Burger model were estimated through nonlinear regression. The effect of the chemical compositions on the rheological parameters based on creep behavior of cooked rice was assessed. Correlation analysis indicated that the retarded elastic modulus, ?2, had positive correlations with protein (r = 0.952, P = 0.048). The relaxation time, ?, had negative correlation with protein content (r = -0.909, P = 0.091). The viscosity coefficient, ?1, was negatively correlated to amylose (r = -0.915, P = 0.085). The analysis between creep parameters and sensory evaluation showed that the viscosity coefficient, ?1, positively correlated to stickiness and total evaluation of cooked rice. So it can be used to evaluate the eating quality of cooked rice.
A mathematical model for the rotary dryer that determines the total residence time is developed. Experiments were performed in a laboratory-scale direct contact rotary dryer with the gas flowing concurrently with the solids. The model predictions depicted that the total residence time decreases with increasing the inclination of the rotary drum, the speed of rotation and the radius of rotary drum. The validation of the model was carried out experimentally for maize while varying the inclination of the rotary drum and the speed of rotation. The experimental results were observed to be in good agreement with the model predictions.
Mathematical models including mass and energy conservation were developed in order to predict the outlet particles temperature and moisture. As the inlet air temperature increased, the outlet particles temperature increased as well and the outlet particles moisture decreased quickly. The outlet particles temperature and moisture changed a little as a function of the speed of rotation at the low inlet air temperature, while the outlet particles temperature and moisture increased very apparently with the speed of rotation increased at the high inlet air temperature. The error of the simulation results compared to the experimental data showed good accuracy for particles temperature and moisture content. The mathematical model performs well to predict the outlet particles temperature and moisture content.
Early diagnosis is a key to improve the prognosis of renal cell carcinoma (RCC); however, reliable RCC biomarkers are lacking in clinical practice. In this study, we used isobaric tags for relative and absolute quantification-based mass spectrometry to identify salivary proteins as biomarkers for the diagnosis of RCC. The objective of this study is to discover biomarkers from saliva by utilizing high-throughput quantitative proteomics approaches. Saliva proteins from 124 RCC patients and healthy individuals were identified and quantified. RCC putative biomarkers were verified by real-time polymerase chain reaction or enzyme-linked immunosorbent assay in a prevalidation sample set. Seventy-one differentially expressed salivary proteins were identified. Serotransferrin, haptoglobin, KRT9, and S100A9, which in previous studies were found to be most closely related to cancers, were selected as putative RCC biomarkers. Haptoglobin and S100A9 were significantly elevated in RCC compared with healthy control samples, although the expression of serotransferrin and KRT9 did not differ between the groups. Furthermore, receiver operating characteristic curves with a cut-off value of 75.49 ng/mL for S100A9 revealed a sensitivity of 87.10% and a specificity of 91.94% for discriminating RCC patients from healthy individuals. Salivary haptoglobin differentiated RCC patients from healthy controls with a sensitivity of 85.48% and specificity of 80.65% (cut-off value 43.02 µg/mL). These results provide experimental evidence to support S100A9 and haptoglobin as potential novel, noninvasive biomarkers for the diagnosis of RCC.
Antistatic fibers or conductive fibers can be obtained from formation of a metal conductive layer, for example silver, on the surface of polymeric fibers through a redox reaction. However, in the process of fabricating silver-polymer conductive fibers, the binding force between silver and the polymeric fiber matrix is too weak and the poor weather resistance greatly affects the performance of the conductive fibers. This work aims to synthesize composite conductive layers of polyaniline (PANi)-silver coated on polyester fibers to prepare conductive polymeric fibers, in order to improve the combining ability between the conductive layers and the fiber matrix. The morphology, thermostability, mechanical properties, washing resistance and corrosion resistance of the resultant fibers obtained from different synthesis conditions were characterized. Batch experimental results showed that the concentration of the reagent and the reaction time could affect the resistance of the PANi-silver coated conductive fibers. The results also demonstrated that the PANi-silver composite conductive fibers have better properties than those of the silver-polymer conductive fibers.
STGC3 is a novel candidate tumor suppressor gene that was found to be associated with nasopharyngeal carcinoma (NPC) via the cDNA cloning and RACE processes. The biological function of the STGC3 protein and its expression level in nasopharyngeal carcinoma remain unknown. This study aimed to evaluate the STGC3 protein expression level in NPC and to investigate the inhibitory function of STGC3 as a candidate tumor suppressor gene. We assessed the expression of the STGC3 protein in NPC biopsies and normal control specimens via Western blot and immunohistochemical analysis. The expression of STGC3 as induced by doxycycline (Dox) via a tetracycline (Tet)-regulated system in human nasopharyngeal carcinoma cell line CNE2 was also established, and the effect of STGC3 restoration on the biological behavior of CNE2 was observed. A reduced level of STGC3 expression (0.978 ± 0.213 versus 0.324 ± 0.185, P < 0.05) was detected in NPC versus normal nasopharyngeal tissue by Western blot assay. Immunohistochemical assays for STGC3 detected positive staining in the nuclei and cytoplasm of epithelial cells, and the positive expression rate in NPC, 8 of 21 (38%), was lower than that in normal nasopharynx samples, 16 of 22 (72%). After STGC3 expression was restored, the growth capacity and clone formation potential of CNE2 cells in soft agar were significantly suppressed, and the cell percentage in G0/G1 phase increased, while the percentage of cells entering the S and G2 phases decreased. This indicates that an abnormality in STGC3 expression is associated with nasopharyngeal carcinogenesis and that it may play an important role in controlling cell growth and regulating the cell cycle.