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Anti-ulcerogenic Lignans from Taxus baccata L. Ilhan Gurbuz, Nurgun Erdemoglu, Erdem Yesilada*, and Bilge Sener Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Hipodrom 6330, Ankara, Turkey. Fax: +90-312-2235018. E-mail: * Author for correspondence and reprint requests Z. Naturforsch. 59c, 233Ð236 (2004); received September 23/November 11, 2003 Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-iso- lariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in

Phytochemical and Antiulcerogenic Properties of Rhizomes from Simaba ferruginea St. Hill. (Simaroubaceae) Vânia Floriani Noldina, Domingos Tabajara de Oliveira Martinsb, César Marcos Marcellob, Joaquim Corsino da Silva Limab, Franco Delle Monachec, and Valdir Cechinel Filhoa,* a Programa de Mestrado em Ciências Farmacêuticas e Núcleo de Investigações Quı́mico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaı́ (UNIVALI), Itajaı́, 88302-202, Santa Catarina, Brazil. Fax +473417601. E-mail: b Área de Farmacologia, Departamento de

Antiulcerogenicity of the Flavonoid Fraction from Erica andevalensis Cabezudo-Rivera M. Reyesa, C. Martín3, C. Alarcón de la Lastra3, J. Trujillob, M. V. Toro3 and M. J. Ayuso3 a Laboratorio de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de Sevilla, C/Prof. Garcia Gonzalez s/n, 41012 Sevilla. Espana b Instituto de Productos Naturales y Agrobiologi'a de Canarias, CSIC, Avda. Astrofi'sico Francisco Sanchez, 2, 38206 La Laguna (Tenerife), Espana Z. Naturforsch. 51c, 563-569 (1996); received January 29/March 6 , 1996 Erica andevalensis

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae) Sérgio F. Andradea,c,*, Daiane Antoniollia, Eros Comunelloa, Luis G. V. Cardosob, José C. T. Carvalhob, and Jairo K. Bastosc a Grupo de Inovações Tecnológicas, Área de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Campus de Videira, 89560Ð900, SC, Brazil. Fax: +4935511444. E-mail: b Laboratório de Fitofármacos, Universidade de Alfenas, Campus de Alfenas, MG, Brazil c Faculdade de

negative for saponins, phlobatannins and anthraquinones. The presence of phenolic metabolites, such as condensed tannins [4] and flavonoids [5], and triterpenes [6, 7] could justify the usage of some species of Strophanthus as anti-inflammatory and antiulcerogenic remedies. This study was carried out to investigate the antinociceptive, anti-inflammatory and antiulcerogenic activities of ethanol root extract of S. hispidus using standard models. Materials and methods Plant material The roots of S. hispidus were collected from Onigambari forest reserve in Oyo State

mucosal surface and the luminal contents [ 22 ]. In conditions where the integrity of the wall of the gastrointestinal tract is threatened, gastric mucus production may be increased. In addition, the biochemical characteristics of the component mucin molecules may change [ 23 ]. Different models of ulcer induction have been employed by various workers, IND being among such models. The IND model has been utilized for screening new compounds for their anti-ulcerogenic effects, especially for those that support the mucosal defense [ 24 ], [ 25 ]. Gastric ulcer has been


Background: Oxidative free radicals and lipid peroxidation mediate gastric injury. α-Tocopherol is a redox agent with biological and antioxidant property, hence, may provide ulcer protection.

Methods: Pylorus-ligated Shay rats (n=6) were used as the experimental gastric ulcer animal model. The rats were divided into three groups. Group I received saline (5 mL/kg), Group II α-tocopherol (12.5 mg/kg), and Group III omeprazole (3.6 mg/kg), orally daily for 5 days prior to ulcerogenic challenge. Nineteen hours after the challenge, the rats were sacrificed and their stomachs isolated and studied for degree of gastric injury. Formed gastric juice was collected for measurement of volume, titrimetric estimation of free and total acidity, and total acid output by the conventional methods. The ulcer index and total acid outputs were calculated.

Results: α-Tocopherol exerted significant (p<0.05) antiulcer activity (the ulcer index was reduced to 7.4±1.0 from the control value of 19.8±4.1). α-Tocopherol also significantly reduced free and total acidity, gastric juice volume, and total acid output (p<0.01). The results were analyzed by ANOVA and Scheffe’s multiple comparison test.

Conclusions: The study demonstrates that α-tocopherol has significant antiulcer activity. It, perhaps, acts by decreasing hydrochloric acid output.

(2007); received January 12/March 2, 2007 In this study, the antiulcerogenic effect of essential oil from Baccharis dracunculifolia was evaluated using the model of acute gastric lesions induced by ethanol. The ulcerative lesion index (ULI) was significantly reduced by oral administration of the essential oil of B. dracun- culifolia at doses of 50, 250 and 500 mg/kg which reduced the lesions by 42.79, 45.70 and 61.61%, respectively. The analysis of the chemical composition of the essential oil from B. dracunculifolia by GC showed that this was composed mainly of mono

NMR, HMQC, HMBC and COSY). The resin extract showed antiulcerogenic activity against ethanol-induced stomach ulcers in Sprauge Dawely rats using ranitidine as standard. In addition, the resin and the isolated compounds showed variable cytotoxic activities against breast (MCF7) and colon (HCT116) cancer cell lines. Key words: Araucaria heterophylla, Labdane Diterpenes, Antiulcerogenic and Cytotoxic Activities NC_11_12_2009.indb 819 08.12.2009 15:51:12 820 E. Abdel-Sattar et al. · Chemical and Biological Investigation of Araucaria heterophylla Extraction

a synthetic route toward the antiulcerogenic compound cassiol (2) by an olefination reaction of 3 and an alternative sequence involving a Michael addition followed by an aldol condensation of an open sub- strate, are also reported. The trisporic acids (1a, 1b, 1c), a group of fungal pheromones [1], and cassioside (2a), a potent anti- ulcerogenic agent isolated from Cinnamomum cassia [2], constitute a small family of natural products derived from β-carotene. Several synthetic routes directed to specific members of the group of trisporic acids have been reported