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knowledge, no reports on keratinase production from Gibberella genus have been presented to date. In order to explore a promising keratinase catalyst for its utilization in detergent formulations, the Gibberella intermedia CA3-1 keratinase was studied, which was previously isolated from soil by Wu et al. (2013) and preserved in our laboratory. It was deposited in the China General Microbiological Culture Collection Center (CGMCC 4903, Beijing, China). In this study, keratinase production by G. intermedia CA3-1 was improved and the keratinase has been characterized

Metabolism of the Phytoalexin Rishitin by Gibberella pulicaris Is Highly Reduced in Liquid Culture Klaus-M. Weltring and Martin Altenburger* Institut für Botanik, Westfälische Wilhelms-Universität, Schloßgarten 3, D-48149 Münster, Germany Z. Naturforsch. 53c, 806-810 (1998); received March 19/April 16, 1998 Fusarium , Degradation, Ascomycetes Gibberella pulicaris is a causal agent of potato dry rot. The fungus is able to metabolize the potato phytoalexin rishitin, a trait which is possibly associated with virulence against potato tubers. Metabolism of the

Microbial Transformation of a - and γ-Eudesmols Mixture Galal T. Maatooq University of Mansoura, Faculty of Pharmacy, Department of Pharmacognosy, Mansoura 35516, Egypt. E-mail: galaltm@mans.edu.eg Z. Naturforsch. 57c, 654Ð659 (2002); received January 2/February 21, 2002 Eudesmol, Gibberella suabinetti, Biotransformation Beta- and gamma-eudesmols mixture was microbiologically transformed by Gibberella sua- binetti ATCC 20193. Seven different eudesmanoidal metabolites (3Ð9) were isolated and their structures were elucidated by the different spectroscopic

338 Notizen Formation of Fusaric Acid by Fungi of the Genus Fusarium W.-U. Mutert, H. Lütfring, and W. Barz Lehrstuhl für Biochemie der Pflanzen der Universität Münster, Hindenburgplatz 55, D-4400 Münster D. Strack Botanisches Institut der Universität zu Köln Z. Naturforsch. 36 c, 338-339 (1981); received January 19, 1981 Fusaric Acid, Fusarium, Gibberella, Biosynthesis, High Performance Liquid Chromatography Among various Fusarium strains tested Gibberella fuji- kuroi (SAW) WR was shown to be a high producer of the phytotoxin fusaric acid. During studies

,4-diene-3,20-dione (10). The struc- tures of the metabolites 3 – 10 were deduced on the basis of spectroscopic methods. Compound 3 was identified as a new metabolite, which exhibited a promising inhibitory activity against the α-glucosidase enzyme. Key words: 11α-Hydroxyprogesterone, 17α-Hydroxyprogesterone, Microbial Transformation, Cunninghamella elegans, Candida albicans, Fusarium lini, Gibberella fujikuroi, α-Glucosidase Inhibition Introduction Microorganisms, particularly fungi, have been used successfully as in vitro models for the prediction of drug metabolism [1

Diseases are manifestations of complex biological processes in living systems. Through the applications of molecular biology and genetics, many diseases are now understood at the molecular level. This has provided researchers opportunities to develop lead molecules with the capacity of blocking a particular disease mechanism. Diabetes is a complex metabolic disorder, characterized by hyperglycemia. The first objective of antidiabetic chemotherapy is to achieve normal glycemic index. Recently, major discoveries have been made to understand how the disease progresses and manifests its complications. We have used this growing understanding to work toward discovery of effective α-glucosidase inhibitors and antiglycation agents of natural and synthetic origins. Reliable bench-top biochemical assays were employed, and several new molecular entities were studied with reference to their structure-activity relationships.

., 2007). In continuation of our stud- ies on basidiomycete-derived bioactive secondary metabolites employed as antifungal agents. The methanolic extract of the fruiting bodies of the mushroom A. tabescens was found to show anti- fungal activity against Gibberella zeae, Colletotri- chum ophiopogonis and Gloesporum fructigenum. The active compound against Gibberella zeae was isolated from the fruiting bodies of A. tabescens by bioassay-guided fractionation of the extract and identifi ed as armillarisin B. In this report, we describe the isolation, structural

Degradation of 3,9-Dimethoxypterocarpan and Medicarpin by Fusarium proliferatum Klaus-Michael Weltring and Wolfgang Barz Lehrstuhl für Biochemie der Pflanzen, Westfälische Wilhelms-Universität, Hindenburgplatz 55, D-4400 Münster Z. Naturforsch. 35 c, 399-405 (1980); received March 10, 1980 Phytoalexins, 3,9-Dimethoxypterocarpan, Medicarpin, Fusarium, Degradation, Demethylation The degradation of 3,9-dimethoxypterocarpan was investigated in selected strains of Fusarium. Fusarium proliferatum (/'. e. Gibberella fujikuroi (SAW)WR) degrades this substrate via 3

biotransformation of a mixture of argentatin A (20%) 1 and incanilin (80%) 2 by Gibberella suabinetti ATCC 20193 and Septomyxa affinis ATCC 6737 demonstrated the con- version of incanilin to 16-hydroxylanosta-2, 8, 23-triene, while argentatin A did not react. The acetate of this triterpenoid mixture was biotransformed by Septomyxa affinis ATCC 6737 to give five metabolites. Argentatin A acetate was transformed to 3, 16,30-trihydroxy- cycloart-20, 24-diene, 20R, 24R-epoxy-16, 25-dihydroxy-3, 4-seco-cycloart-4(28)-en-3-oic acid acetate and 20R, 24R-epoxy-16, 25-dihydroxy-3, 4-seco

production for assessment of resistance in cereals inoculated with Fusarium culmorum. Eur. J. Plant Pathol. 103: 589–595. http://dx.doi.org/10.1023/A:1008693213656 [16] McCallum B.D., Tekauz A. & Gilbert J. 2001. Vegetative compatibility among Fusarium graminearum (Gibberella zeae) isolates from barley spikes in southern Manitoba. Can. J. Plant Pathol. 23: 83–87. [17] Mesterházy A. 1997. Methodology of resistance testing and breeding against Fusarium head blight and results of the selection. Cereal Res. Commun. 25: 631–637. [18] Mesterházy A. 2002. Role of deoxynivalenol