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R eferences 1. Ghasemi R, Haeri A, Dargahi L, Mohamed Z, Ahmadiani A . Insulin in the brain: sources, localization and functions. Mol Neurobiol 47: 145-171, 2013. 2. Kleinridders A, Ferris HA, Cai W, Kahn CR . Insulin action in the brain regulates systemic metabolism and brain function. Diabetes 63: 2232-2243, 2014. 3. Yin F, Boveris A, Cadenas E . Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid, Redox Signal 20: 353-371, 2014. 4. Camandola S, Mattson MP . Brain metabolism in health, aging, and

Radiation Aggregates of Insulin Jiřina Kopoldová Isotope Laboratory of the Institutes for Biological Research, Czechoslovak Academy of Sciences, Prague Z. Naturforsch. 34 c, 1139 — 1143 (1979); received January 22/M ay 4, 1979 Gamma-Irradiation, Insulin, Aqueous Solution, Radiation Aggregates During the irradiation of aqueous solution of insulin (pH 1.8) the decrease of original insulin molecules and the formation of radiation aggregates of insulin was studied in dependence on the concentration of irradiation solution, on the doses and conditions of

References Kimball SR, Vary TC, Jefferson LS. Regulation of protein synthesis by insulin. Annu Rev Physiol. 1994;56:321-48. Randazzo PA, Morey VA, Polishook AK, Jarett L. Characterization of the growth of murine fibroblasts that express human insulin receptors. I. The effect of insulin in the absence of other growth factors. Exp Cell Res. 1990;190(1):25-30. Taub R, Roy A, Dieter R, Koontz J. Insulin as a growth factor in rat hepatoma cells. Stimulation of proto-oncogene expression. J Biol Chem. 1987;262(22):10893-7. Sell SM, Reese D, Ossowski VM. Insulin

References 1. Chevenne D, Trivin F, Porquet D. Insulin assays and reference values. Diabetes Metab 1999; 25:459–76. 2. Clark PM. Assays for insulin, proinsulin(s) and C-peptide. Ann Clin Biochem 1999; 36:541–64. 3. Crowther NJ, Gray IP. Immunometric assays of insulin and its precursors. J Clin Ligand Assay 1996; 19:112–20. 4. Bowsher RR, Lynch RA, Brown-Augsburger P, Santa PF, Legan WE, Woodworth JR, et al. Sensitive RIA for the specific determination of insulin lispro. Clin Chem 1999; 45:104–10. 5. Andersen L, Jørgensen PN, Jensen LB, Walsh D. A new insulin

© Freund Publ ishing House Ltd., London Journal of Pediatr ic Endocr inology & Metabol i sm, 15, 369-376 (2002) Comparative Trial Between Insulin Glargine and NPH Insulin in Children and Adolescents with Type 1 Diabetes Mellitus Edith Schober1, Eugen Schoenle2, Jacobus Van Dyk3, Karin Wernicke-Panten4 and the Pediatric Study Group of Insulin Glargine* 'University Children's Hospital, Vienna, Austria, 2University Children's Hospital, Zurich, Switzerland, 3 University of Pretoria, Pretoria Academic Hospital, South Africa and 4Clinical Development, Aventis