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expression of their lipophilic character in structure-activity studies, J. Med. Chem . 18 (1975) 873–883; 14. E. Kłosińska-Szmurło, F. A. Pluciński, M. Grudzień, K. Betlejewska-Kielak, J. Biernacka and A. P. Mazurek, Experimental and theoretical studies on the molecular properties of ciprofloxacin, norfloxacin, pefloxacin, sparfloxacin, and gatifloxacin in determining bioavailability, J. Biol. Phys. 40 (2014) 335–345; 15. B. J. Bennion, N. A. Be, M. W. McNerney, V. Lao, E. M. Carlson, C. A

, D.R. Richardson, D. Kalinowski, B. Podeszwa, J. Finster, H. Niedbala, A. Palka, J. Polanski, Bioorg. Med. Chem. 15, 1280 (2007) [20] C.A. Lipinski, F. Lombardo, B.W. Dominy, P.J. Feeney, Adv. Drug. Delivery Rev. 23, 4 (1997) [21] A. Avdeef, Curr. Topics Med. Chem. 1, 277 (2001) [22] V. Pliska, In V. Pliska, B. Testa, H. van der Waterbeemd (Eds.), Lipophilicity in Drug Action and Toxicology (Wiley-VCH, New York, 1996) 1 http

expert group on (Quantitative) Structure–Activity Relationships ((Q)SARs) on the principles for the validation of (Q)SARs. 2004, pp. 11–198. 24. Palm K., Luthman K., Artursson P.: An alternative explanation for the low membrane permeability of highly lipophilic drugs. Eur J Pharm Sci 1996, 4, 195–195. 25. Peng Y.; Taylor J. M., Yu B. A marginal regression model for multivariate failure time data with a surviving fraction. Lifetime Data Anal 2007, 13, 351–369. 26. Piatkowska M., Jedziniak P., Zmudzki J.: Review: Residues of veterinary medicinal products and

.amjhyper.2005.06.002 [48] Sauer, W. H., Baer, J. T., Berlin, J. A., and Kimmel, S. E., Am. J. Cardiol. 94, 1171 (2004). [49] Tetko, I. V. and Poda, G. I., J. Med. Chem. 47, 5601 (2004). [50] Lombardo, F., Shalaeva, M. Y., Bissett, B. D., and Chistokhodova, N., in LogP2004, The 3rd Lipophilicity Symposium, ETH: Zurich, Switzerland, 2004, p. L–22. [51] Hou, T. J., Zhang, W., Xia, K., Qiao, X. B., and Xu, X. J., J. Chem. Inf. Comput. Sci. 44, 1585 (2004). [52

Determination of the Lipophilicity of Some New Derivatives of Semi- carbazide and 1,2,4-Triazol-5-one with Potential Antibacterial Activity Monika Pituchaa, Beata Polakb, Ryszard Świebodac, Urszula Kosikowskad, and Anna Malmd a Department of Organic Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland b Department of Physical Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland c Department of Inorganic Chemistry, Chair of Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland d Department of Pharmaceutical Microbiology, Medical

Lipophilic Exudate Constituents of Some Rosaceae from the Southwestern USA Eckhard Wollenweber. Birgit Henrich. Karin Manna and James N. Roitmanb Institut für B otanik der Technischen Hochschule. Schnittspahnstraße 3. D-64287 D arm stadt. B undesrepublik D eutschland Z. N aturforsch. 51c, 296-300 (1996); received January 9/February 12, 1996 Rosaceae, Epicuticular M aterial, Flavonoid Aglycones, Triterpene Acids The lipophilic epicuticular m aterial of four shrubby Rosaceae from the Southw estern U SA has been studied. They all exhibit triterpene acids as m

Lipophilic Phenolic Constituents from Helichrysum Species Endemic to Madagascar Michel R andriam inahya, Peter Proksch3, Ludger W itteb, and Victor W rayc a Institut für Botanik und Pharmazeutische Biologie, Universität Würzburg, Mittlerer Dallen- bergweg 64, D-8700 Würzburg, Bundesrepublik Deutschland b Institut für Pharmazeutische Biologie, TU Braunschweig, Mendelssohnstraße 1, D-3300 Braunschweig, Bundesrepublik Deutschland c Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-3300 Braunschweig, Bundesrepublik Deutschland Z. Naturforsch

discussed in the litera- ture (e.g. Freudenberg 1968; Ayres and Loike 1990; Lewis et al. 1998; Gang et al. 1999). In this paper we present results from analysis of the hydrophilic and lipophilic extractives of knots from 7 Norway spruce trees. The objective was to determine the amount and composition, as well as the variability within a tree and between trees, of the extractives in knotwood and stemwood. We were also interested in differences due to geographical location, therefore 2 of the 7 trees were sampled from northern Finland and the other 5 from southern Finland

Pure Appl. Chem., Vol. 73, No. 9, pp. 1465–1475, 2001. © 2001 IUPAC 1465 Gradient HPLC in the determination of drug lipophilicity and acidity* Roman Kaliszan†, Piotr Haber, Tomasz Bączek, and Danuta Siluk Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland Abstract: The linear-solvent strength (LSS) model of gradient elution in high-performance liquid chromatography (HPLC) has been demonstrated to provide parameters of lipophilici- ty and acidity of analytes. pKa and log kw values are

, are referred to as pitch and they contain considerable amounts of wood lipophilic com- pounds (Mutton 1962). Lipophilic wood extractives are comprised mainly of fatty acids, resin acids, waxes, alco- hols, terpenes, sterols, sterol esters and glycerides (Sjö- ström 1993) and the different classes of extractives have dif- ferent chemical behavior during and after pulping. In neu- tral to acidic processing of the wood, the lipophilic extrac- tives are difficult to remove, and resinous woods, are more of a problem in pitch control. However, in alkaline process- ing