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peptides/proteins in a given biological sample, were an important focus over the past decade [1]. This is explained by the availability of extensive genomic data, by technological advances in the field of micro- and nanotechnologies, and in the development of robust mass spectrometry (MS) methods [2]. Indeed, recent improvements in MS technology have achieved better sensitivity, specificity, and throughput. However, as with any innovative technology, translation from research to clinical use is a significant challenge [3]. Not only are there analytical considerations to

1 Introduction At present, inorganic mass spectrometry (MS) [ 1 ] represents a group of well-established and well-known analytical techniques. The term can correspond to the definition by Koppenaal as “the mass spectrometric measurement of atomic (as opposed to molecular or polyatomic) ions, for the primary purpose of elemental and/or isotopic composition determinations” [ 2 ]. Then, the term of atomic MS is also used to refer these techniques. Inorganic MS is based on the different physical properties of the atom nuclei. A chemical element can have a fixed

Pyrolysis Mass Spectrometry of Protected Phosphotriester Oligodeoxyribonucleotides J. Ulrich M. J. Bobenrieth Laboratoire de Spectrometrie de Masse, DCh/DCA/CAG/EAPC, Centre d'Etudes Nucleaires de Grenoble, 85 X, 38041 Grenoble Cedex, France R. Derbyshire, F. Finas, A. Guy, F. Odin, M. Polverelli, and R. Téoule* Laboratoire de Radiobiochimie, Départment de Recherche Fondamentale, Centre d'Etudes Nucléaires de Grenoble, 85 X , 38041 Grenoble Cedex, France Z. Naturforsch. 35b, 212-216 (1980); received July 16, 1979 Phosphotriester Protected

Volume 7, Issue 2 2008 Article 1 Statistical Applications in Genetics and Molecular Biology COMPETITION ON CLINICAL MASS SPECTROMETRY BASED PROTEOMIC DIAGNOSIS International Competition on Mass Spectrometry Proteomic Diagnosis Bart Mertens, Leiden University Medical Centre Recommended Citation: Mertens, Bart (2008) "International Competition on Mass Spectrometry Proteomic Diagnosis," Statistical Applications in Genetics and Molecular Biology: Vol. 7: Iss. 2, Article 1. DOI: 10.2202/1544-6115.1348 International Competition on Mass Spectrometry Proteomic Diagnosis

conditions required to produce and purify membrane proteins and their complexes. In addition, membrane proteins represent challenging targets for classical structural techniques such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy which require a large amount of pure and homogeneous sample. Nonetheless, despite the challenges of protein production, most of the available structures of membrane proteins originate from these techniques. In the cases where sample amounts are low or the sample is not homogeneous, mass spectrometry (MS) contributes a

best use of antibiotics. In this way the recent (r)evolution in clinical microbiology approach could help to improve this problem. Different solutions have increased: first the molecular diagnostic methods (e.g., 16S ribosomal RNA sequencing, real-time PCR for detection of selected genes) which is classically used in parallel with routine bacteriological methods; and second mass spectrometry (MS) which is propelling us into a new era far beyond the classical bacteriology of Louis Pasteur. These promising new broad-based techniques have merit, since they can rapidly

Presparking Effect in Spark Source Mass Spectrometry A. Harfoush Atomic Energy Commission of Syria, Damascus, Syria S. Sh. Soulayman High Institute for Applied Sciences and Technology, Damascus, Syria Z. Naturforsch. 47a, 748-752 (1992); received September 12, 1989 The Relative Sensitivity Factor (RSF) in Spark Source Mass Spectrometry analysis was found to be dependent on the number and duration of previous sparking periods. This dependency becomes very strong when dealing with volatile elements. By statistical analysis of experimental RSF values it was

Josefina Pérez-Arantegui and Francisco Laborda 3 Inorganic mass spectrometry Abstract: Inorganic mass spectrometry has been used as a well-known analytical technique to determine elemental/isotopic composition of very diverse materials, based on the different mass-to-charge ratios of the ions produced in a specific source. In this case, two mass spectrometric techniques are explained and their analytical properties discussed: inductively coupled plasma mass spectrometry (ICP-MS) and thermal ionisation mass spectrometry (TIMS), since they are the most used in art

.1002/1522-2683(20000601)21:11<2105::AID-ELPS2105>3.0.CO;2-M [6] A. Pandey, M. Mann, Nature 405, 837 (2000) http://dx.doi.org/10.1038/35015709 [7] W.H. McDonald, J.R. Yates, Traffic 1, 747 (2000) http://dx.doi.org/10.1034/j.1600-0854.2000.011001.x [8] R. Aebersold, D.R. Goodlett, Chemical Reviews 101, 269 (2001) http://dx.doi.org/10.1021/cr990076h [9] J. Godovac-Zimmermann, L.R. Brown, Mass Spectrometry Reviews 20, 1 (2001) http://dx.doi.org/10.1002/1098-2787(2001)20:1<1::AID-MAS1001>3.0.CO;2-J [10] M. Stoeckli, P. Chaurand, D.E. Hallahan, R.M. Caprioli, Nature Medicine 7, 493 (2001) http

Physical Chemistry , 3rd ed. (the “Green Book”). Prepared for publication by E. R. Cohen, T. Cvitaš, J. G. Frey, B. Holmström, K. Kuchitsu, R. Marquardt, I. Mills, F. Pavese, M. Quack, J. Stohner, H. L. Strauss, M. Takami, A. J. Thor, RSC Publishing, Cambridge, UK (2007). 8 10.1016/1044-0305(91)80025-3 , P. Price. J. Am. Soc. Mass Spectrom. 2 , 336 (1991). 9 American Society for Mass Spectrometry: http://www.asms.org/. 10 O. D. Sparkman. Mass