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Introduction Mitochondria are central in cellular energy production, metabolism and signaling. Mitochondria have two membranes, the outer membrane (OM) and inner membrane (IM), and two aqueous compartments, the intermembrane space (IMS) between the OM and IM and the innermost matrix, and consist of ~1000 different proteins and >400 different lipids, including fatty acids, glycerophospholipids, glycerolipids, sphingolipids and prenols ( Bird et al., 2013 ). Since mitochondria cannot be made de novo , synthesis and transport of proteins and lipids are a

was found in 80% and 90% of patients with vascular injury and coronary heart diseases, respectively, [ 4 ] besides, the presence of calcification usually predicted poor clinical outcomes especially in coronary atherosclerotic diseases. [ 5 ] Mitochondria were the most crucial energy metabolism factories of cells. Mitochondria could produce adenosine triphosphate (ATP) and a variety of biosynthetic intermediates, participate in oxidative stress, and affect autophagy and apoptosis. Therefore, the quality and activity of mitochondria were closely related to the state

pathophysiological consequences. EMBO J. 2012;31(14):3038-62; DOI:10.1038emboj.2012.170. 16. Pickles S, Vigié P, Youle R. Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance. Curr Biol. 2018;28(4):R170-R185; DOI:10.1016/j.cub.2018.01.004. 17. Yao Z, Wood N. Cell Death Pathways in Parkinson’s Disease: Role of Mitochondria. Antioxid Redox Signal. 2009;11(9):2135-49; DOI: 10.1089/ARS.2009.2624. 18. Franco-Iborra S, Vila M, Perier C. The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? Neuroscientist. 2016;22(3):266-77; DOI:10.1177/1073858415574600. 19

Isolation and Respiratory Assay of Earthworm Body Wall Mitochondria T. V. Rao and U. C. Biswal Biophysics and Biochemistry Lab., School o f Life Sciences, Sambalpur University, Burla-768017, India Z. Naturforsch. 39 c, 853-855 (1984); received January 23, 1984 Earthworm Mitochondria, Isolation, Respiratory Assay, Metabolism, Oxidative Phosphorylation Out o f several media tested, KC1 medium contain­ ing BSA was found to be most suitable for isolation o f functionally efficient mitochondria from earthworms. Respiration and oxidative phosphorylation in

Introduction: mitochondria and oxidative phosphorylation Mitochondria play a key role in multiple cellular processes such as energy generation, biosynthesis, reactive oxygen species (ROS) production as well as cell death. Similar to other essential cellular functions like cytoskeleton remodeling or DNA replication, mitochondrial respiration can be targeted to induce cell death in specific situations, such as in cancer. Respiration is driven by the oxidative phosphorylation (OXPHOS) system, which resides in the mitochondrial inner membrane (MIM) and consists of

1288 Notizen Adenine Phosphoribosyltransferase Activity in Mitochondria o f Catharanthus roseus Cells Fumiko Hirose and Hiroshi Ashihara Department of Biology, Faculty of Science, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, 112 Japan Z. Naturforsch. 37 c, 1288 - 1289 (1982); received June 29, 1982 Catharanthus roseus (= Vinca rosea), Adenine Phosphori­ bosyltransferase, Subcellular D istribution, Mitochondria, Purine Salvage Subcellular localization of adenine phosphoribosyltrans­ ferase was examined in Catharanthus roseus cells. At least 13% of the

Introduction – mitochondria contain two distinct redox networks Mitochondria are essential organelles of eukaryotic cells. They produce not only the bulk of cellular energy in the form of ATP, but they also generate numerous important metabolites and cofactors, and they serve as critical signaling stations that, for example, integrate cellular signals to initiate apoptosis. In turn, mitochondria also communicate their metabolic and fitness state to the remainder of the cell to trigger cellular adaptation processes. Mitochondria contain two distinct aqueous

cAMP-Dependent Protein Kinase Activity in Yeast Mitochondria G ünter Müller* and Wolfhard Bandlow Institut für Genetik und Mikrobiologie der Universität München, Maria-Ward-Straße la , D-8000 München 19, Bundesrepublik Deutschland Z. Naturforsch. 42c, 1291 — 1302 (1987); received May 29/August 3. 1987 cAMP-Dependent Protein Kinase, Protein Phosphatase, Yeast, Mitochondria, Sub-Mitochon- drial Location Two different cAMP-binding proteins have been identified in yeast mitochondria by photo­ affinity labelling and based on the occurrence of cAMP-binding activity