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Introduction Mitomycin C (MMC) is widely used in treatment of non-muscle invasive bladder cancer (NMIBC). In the intravesical instillation indication, according to the Ametycine ® product information [ 1 ], the MMC concentration required is 1 mg/mL in water for parenteral administration or 0.9 % sodium chloride solution. This solution has to be prepared extemporaneously and an administration kit is delivered by the manufacturer. Its pharmacological activity is probably due to the quinone, carbamate and aziridine groups that composed the molecule [ 2 ]. After a

with mitomycin C at the G(0) phase. Cytogenet Cell Genet 1999; 85(2): 212-216. Leonard A, Rueff J, Gerber GB, Leonard ED. Usefulness and limits of biological dosimetry based on cytogenetic methods. Radiat Prot Dosimetry 2005; 115(1-4): 448-454.

chemotherapeutic treatment is to maximize the total drug concentration in the peritoneal tumor nodules with passive diffusion [ 7 ] while minimizing that delivered to the systemic circulation [ 7 ]. This treatment permits a median survival of more than 40 months [ 4 , 5 , 8 , 9 , 10 ]. However, the HIPEC protocol is not standardized. Several chemotherapeutic drugs have been used for CR PM treatment: oxaliplatin [ 11 ], mitomycin C (MMC) [ 11 ] or cisplatinium (CDDP). However, there is no consensus on the applied dose, temperature and duration, carrier solution, perfusate

Mitomycin C-Activity Effected by Vitamins B1, C, E and -Carotene under Irradiation with γ-Rays Edith Heinrich and Nikola Getoff* Institute for Theoretical Chemistry and Structural Biology as well as Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, The University of Vienna, Althanstr.14, A-1090 Vienna, Austria. Fax: ++43(1)-4277-52795. E-mail: nikola.getoff@univie.ac.at * Author for correspondence and reprint requests Z. Naturforsch. 58c, 244Ð248 (2003); received October 11/November 7, 2002 Vitamin B1 (thiamine) can essentially effect the

best results are reported for intraarterial radioembolization, with a disease control rate of 72–91% and an overall survival of 6.6–13.6 months. 7 , 10 , 11 , 12 For over 15 years, LMBC patients are treated by intra-arterial chemo infusion with mitomycin C (MMC) in our institute whereby disease control is obtained in 58% with low adverse events in a very heavily pre-treated cohort. 9 Since primary breast cancer is sensitive for both systemic chemotherapy and external beam radiation therapy, LMBC patients might also benefit from the combined treatment of chemo

VERMEHRUNG UND DNS-SYNTHESE DES HERPES-SIMPLEX-VIRUS 671 Vermehrung und DNS-Synthese des Herpes-simplex-Virus nach Mitomycin C - Behandlung K la u s M u n k u n d G e r h a r d S a u e r Institut für Virusforschung Heidelberg (Z. Naturforschg. 20 b, 671—677 [1965] ; eingegangen am 23. Februar 1965) In Herpes-Virus-infizierten HeLa-Kulturen findet sich während der ersten 6 Stdn. der Infektion, gemessen an 3H-Thymidineinbau, der gleiche Anteil an Zellen, die DNS synthetisieren (S-Phase), wie in nicht infizierten Kontrollkulturen. Nach 6 Stdn. p.i. steigt

Bd. 329 (1962) 31 Zur Wirkungsweise von Mitomycin C, I Einfluß von Mitomycin C auf den Desoxyribonucleinsäure-Abbau in ruhenden Bakterien Von H. Kersten Aus dem Physiologisch-Chemischen Institut der Universität Münster/Westfalen Direktor Professor Dr. E. Lehnar tz (Der Schriftleitung zugegangen am 22. Dezember 1961) Mitomycin C wurde in Japan aus einem neuen Actinomyceten- stamm, Streptomyces caespitosus, isoliert1»2. Das tiefviolette, kristalline Produkt hat ein Molekulargewicht von etwa 1120 und in methanolischer Lösung Absorptionsmaxima bei den Wellenlängen

ie - d e r und K ä t h y E g g l e r für ihre zuverlässige Mitarbeit. Uber die Abhängigkeit der bakteriziden Wirkung von M itomycin C auf E. coli B und B/M C von der Temperatur und dem N ährm edium Von U l r i c h W i n k l e r Aus dem Institut für Mikrobiologie der Universität Frankfurt/M. (Z. Naturforschg. 17 b, 670—675 [1962] ; eingegangen am 13. März 1962) The bactericidal effect of Mitomycin C on E. coli B and the partial reactivability of MC induced cell-inactivations depends on the genotype, the composition of the plating medium and the post

Bd. 334 (1963) 141 Zur Wirkungsweise von Mitomyciii C, II1 Einfluß von Mitomycin C, Chloramphenicol und Mg3® auf den RNA- und DNA-Stoffwechsel in Bakterien Von Helga Kersten und Walter Kersten Aus dem Physiologisch-Chemischen Institut der Universität Münster/Westfalen (Direktor: Prof. Dr. E. Lehnar t z ) (Der Schriftleitung zugegangen am 7. März 1963) Herrn Professor Dr. E. Lehnartz zum 65. Geburtstag gewidmet Mitomycin C ist der erste isolierte Naturstoff, der ein Aziridin- Ringsystem enthält. Die Aufklärung der chemischen Konstitution einer Reihe von

ON THE SYNERGISTIC EFFECT OF DOXORUBICIN AND MITOMYCIN C AGAINST BREAST CANCER CELLS Adam J. Shuhendler', Peter J. O'Brien1, Andrew M. Rauth2 and Xiao Yu Wu1* 'Leslie Dan Faculty of Pharmacy, University of Toronto, and2Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada S U M M A R Y The combination of doxorubicin and mitomycin C has been shown previously to result in supra-additive tumor cell killing in vitro in both murine and human breast cancer cells and in vivo against murine breast cancer cells. Median effect analysis