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Mechanisms of Adriamycin-Dependent Oxygen Activation Catalyzed by NADPH-Cytochrome c*-(Ferredoxin)-Oxidoreductase Eva Paur*, Richard J. Youngm an, Edm und L engfelder* , and Erich F. Elstner Institut für Botanik und M ikrobiologie, Technische Universität München, Arcisstrasse 21, D-8000 München 2, Bundesrepublik Deutschland * Institut für Strahlenbiologie, Universität München. Bavariaring 19, D-8000 München 2, Bundesrepublik Deutschland Z. Naturforsch. 39 c, 261 —267 (1984); received Decem ber 15, 1983 Adriamycin, Oxygen Activation, Oxygen Toxicity, Superoxide

Notizen 919 Bleomycin-Iron Complex and Oxygen Activate Algal Ribonucleotide Reductase Rüdiger Hofmann and Hartm ut Follmann Fachbereich Chemie (Biochemie) der Philipps-Universität, Hans-Meerwein-Straße, D-3550 Marburg, Bundesrepublik Deutschland Z. Naturforsch. 40c, 919—921 (1985); received August 22, 1985 Bleomycin, Deoxyribonucleotide Synthesis, Iron, Oxygen Dependence, Ribonucleotide Reduction, Scenedesmus obliquus Ribonucleotide reductase of green algae (Scenedesmus obliquus) is a radical-containing enzyme which rapidly loses activity under anaerobic

10 Toward understanding the mechanism of oxygen activation by fl avoprotein oxidases Marilyn Schuman Jorns Abstract Several common themes have emerged from our recent studies on the mechanism of oxygen activation by monomeric sarcosine oxidase (MSOX ), N-methyltryptophan oxidase (MTOX ), and heterotetrameric sarcosine oxidase (TSOX ). MSOX and MTOX are members of a family of monomeric amino acid oxidases that contain 1 mol of covalently bound FAD . TSOX is a bifunctional, multimeric (αβγδ) enzyme that contains 1 mol each of noncovalently bound FAD and

Biochemical Oxygen Activation as the Basis for the Physiological Action of Tetrachlorodecaoxide (TCDO) R. J. Youngman**, G. R. Wagner, F. W. Kühne*, and E. F. Elstner Institut für Botanik und Mikrobiologie, Biochemisches Labor, Technische Universität München, Arcisstraße 21, D-8000 München 2 * Fa. Oxochemie, D-6900 Heidelberg, Maaßstraße 24 Z. Naturforsch. 40c, 409—414 (1985); received March 18, 1985 Tetrachlorodecaoxide, OxoferinR, Activated Oxygen, Heme Catalysis, Wound Healing Oxidation of methionine, 4-(methylthio)-2-oxobutyric acid (KMB), or 1

PHOTODYNAMIC AND REDUCTIVE MECHANISMS OF OXYGEN ACTIVATION BY THE FUNGAL PHYTOTOXINS, CERCOSPORIN AND DOTHI STROMIΝ Richard J. Youngman and Erich F. Elstner Institut für Botanik und Mikrobiologie, Technische Universität München, Arcisstrasse 21, 8000 München 2, W. Germany. Introduction The fungi Cercospora beticola and Dothistroma pini are responsible for causing leaf spot disease in sugar beet and Dothistroma blight in pine, respectively (1,2). Both fungi produce red coloured pigments cercosporin and dothistromin and toxicity is manifested by a

OXYGEN ACTIVATION BY THE IRON (II)-2-MERCAPTOBENZOIC ACID COMPLEX 6 9 9 Oxygen Activation by the Iron(II)-2-Mercaptobenzoic Acid Complex. A Model for Microsomal Mixed Function Oxygenases V o l k e r U l l r i c h Physiologisch-chemisches Institut der Justus Liebig-Universität Gießen (Z. Naturforschg. 2 4 b , 699— 704 [1969] ; eingegangen am 17. Januar 1969) Es wird ein neues Hydroxylierungsm odell beschrieben, das molekularen Sauerstoff durch einen Eisen (II) -2-mercaptobenzoesäure-Komplex in wäßrigem Aceton reduziert. D ieses M odellsystem wurde aus den

ROLE OF OXYGEN ACTIVATION IN ADRIAMYCIN-MEDIATED DNA STRAND SCISSION AND THE EFFECT OF BINDING ON THE REDOX PROPERTIES OF THE DRUG Richard J. Youngman, Friedrich Götz, Erich F. Elstner, Institut für Botanik und Mikrobiologie, Technische Universität München, Arcisstrasse 21, 8000 München 2, W. Germany. Introduction The anthracyclin adriamycin (ADR) is one of the most promising drugs in the treatment of neoplasia, leukemia and solid tumours (1,2). The quinone moiety of the drug can participate in redox reactions and via subsequent autoxidation, gives rise

Negligible Ability of Oxygen and Peroxide Ion Activation by Al(III) Ion Is Essential for Al(III)-Induced Neurodegeneration Yuzo Nishida Department of Chemistry, Faculty of Science, Yamagata University, Yamagata 990-8560, Japan. FAX: +81-236284591. E-mail: yuzo@sci.kj.yamagata-u.ac.jp Z. Naturforsch. 56c, 865-871 (2001); received March 9/May 7, 2001 Al(III)-Induced Neurodegeneration, Oxygen Activation, Tyrosine Hydroxylase The electron densities of the atoms in Fe(II)- or Al(III)-tyrosine hydroxylase (THO) con­ taining oxygen and pterin were calculated by the DFT

Isolation and Identification of an Oxygen Reducing Factor (ORF) from Isolated Spinach Choloroplast Lamellae J. Firl*, D. Frommeyer, and E. F. Elstner** * Institut für Organische Chemie, ** Institut für Botanik und Mikrobiologie, Technische Universität München, D-8000 München 2 Z. Naturforsch. 36 c, 284-294 (1981); received November 28,1980 Oxygen Activation, Spinach Chloroplast Lamellae, Flavins, Photosynthetic Electron Transport From the water extracts of heat-treated spinach chloroplast lamellae, five compounds were isolated by column chromatography and

Biochemical Model Reactions on the Prooxidative Activity of Homocysteine Gudrun Preibisch, Christina Kiiffner, and Erich F. Elstner Institut für Botanik und Mikrobiologie; Biochemisches Labor, Technische Universität München, Arcisstraße 21, D-W -8000 München, Bundesrepublik Deutschland Z. Naturforsch. 48c, 5 8 -6 2 (1993); received December 1, 1992 Homocysteine, Oxygen Activation, Atherogenesis The sulfur amino acid homocysteine has recently been addressed as marker for vessel dam­ aging and atherosclerotic dispositions. The atherogenic index has been