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Clin Chem Lab Med 2010;48(11):1567–1575 2010 by Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2010.314 2010/502 Article in press - uncorrected proof Review Standardizing plasma protein measurements worldwide: a challenging enterprise Giampaolo Merlini1,*, Søren Blirup-Jensen2, A. Myron Johnson3, Joanna Sheldon4 and Ingrid Zegers5 on behalf of the IFCC Committee on Plasma Proteins (C-PP) 1 Biotechnology Research Laboratories, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Department of Biochemistry, University of

In vitro and in vivo Binding of Epirubicin to Red Blood Cells and Human Plasma Proteins Suzan B andak, M artin Czejka Institut für Pharmazeutische Chemie, Universität Wien, Währingerstraße 10, A-1090 Wien, Österreich Johann Schüller Hospital Rudolfstiftung, Juchgasse 25, A-1030 Wien, Österreich Z. Naturforsch. 49c, 483-488 (1994); received March 28, 1994 Epirubicin, in vivo and in vitro Interaction, Erythrocytes, Plasma Proteins In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely a-HSA, y

350 Notizen Effect of Glucocorticoids, Insulin and a Growth Promoting Tripeptide on the Biosynthesis of Plasma Proteins in Serum-Free Hepatocyte Cultures “Fouad M. Fouad, Mohamed Abd-El-Fattah, Reiner Scherer, and Gerhard Ruhenstroth-Bauer Max-Planck-Institut für Biochemie, D-8033 Martinsried bei München, Bundesrepublik Deutschland Z. Naturforsch. 36 c, 350-352 (1981); received September 19/December 15, 1980 Rat Hepatocytes, Cultures, Plasma Proteins, Glucocorti­ coids, Insulin The effect of cortisol, dexamethasone, insulin and a liver cell growth promoting

need, the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has created a working group on harmonization of the total testing process (WG-H) to promote the use of harmonized nomenclature for measurands, of amounts of substance units and the implementation of common RIs for the measurands where this approach is feasible at the European level [ 7 ]. The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays considering the clinical impact of plasma protein measurements and their relevance in

Review Low Levels of Plasma Proteins: Malnutrition or Inflammation? Clin Chem Lab Med 1999; 37(2):91–96 © 1999 by Walter de Gruyter · Berlin · New York Andrew Myron Johnson Departments of Pediatrics and Obstetrics-Gynecology, Uni- versity of North Carolina School of Medicine, Chapel Hill, North Carolina, USA Levels of several plasma proteins, including albumin, transferrin, and transthyretin (prealbumin), have been proposed as markers for protein energy malnutrition. However, many other factors, especially inflammatory disease and drug or hormone therapy, affect

., 1996, 43, 645–659 [21] Radi R., Peluffo G., Alvarez M.N., Naviliat M., Cayota A., Unraveling peroxynitrite formation in biological systems, Free Radic. Biol. Med., 2001, 5, 463–488 http://dx.doi.org/10.1016/S0891-5849(00)00373-7 [22] Olas B., Saluk-Juszczak J., Nowak P., Glowacki R., Bald E., Wachowicz B., Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteins, Nutrition, 2007, 23, 164–171 http://dx.doi.org/10.1016/j.nut.2006.11.003 [23] Jerlich A., Horakova L, Fabjan J.S., Giessauf A., Jiirgens G., Schaur R

References 1. Lin TM, Galbert SP, Kiefer D, Spellacy WN, Gall S. Characterization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol 1974 ; 118 : 223 –6. 2. Casals E, Aibar C, Martinez JM, Borrell A, Soler A, Ojuel J, et al. First trimester biochemical markers for Down's syndrome. Prenatal Diagn 1999 ; 19 : 8 –11. 3. Aitken DA, Ireland M, Berry E, Crossley JA, Macri JN, Burn J, et al. Second-trimester pregnancy associated plasma protein-A levels are reduced in Cornelia de Lange syndrome pregnancies. Prenatal Diagn 1999 ; 19 : 706 –10. 4

Clin Chem Lab Med 2012;50(7):1183–1190 © 2012 by Walter de Gruyter • Berlin • Boston. DOI 10.1515/cclm-2011-0640 Review Pregnancy-associated plasma protein A: spotlight on kidney diseases Marta Kalousov á 1, *, Vladim í r Tesa r̆ 2 , Alexandra Muravsk á 1 and Tom á š Zima 1 1 Institute of Medical Biochemistry and Laboratory Diagnostics , First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague , Czech Republic 2 Department of Nephrology , First Faculty of Medicine, Charles University in

References 1. Mc Grotty, Y. & Knottenbelt, C. (2002). Significance of plasma protein abnormalities in dogs and cats, Practice, 24, 512-517. DOI: 10.1136/inpract.24.9.512 2. Kaneko, J.J. (1995). Serum proteins and dysproteinemias. In: Clinical Biochemistry of Domestic Animals, Kaneko JJ., 4th edition, Copyright © by Academic Press, Inc., 144-163. 3. Hines, R. (2009). Normal feline and canine blood values. Blood, temperature, urine and other values for your dog and cat, www.2ndchance.info/normaldogandcatbloodvalues.htm. 3. Muthny, T., Kovarik, M., Tilser, I

"NORMAL" PLASMA PROTEINS DURING PREGNANCY B. Teisner Institute of Medical Microbiology, University of Odense, Denmark In a cross-sectional study the levels of circulating enzyme inhibitors (antithrombin III (AT III), c^-macroglobin (c^M), a^ antitrypsin), complement factors (C3, C4, factor B), and split products of C3 (C3c and C3d) were quantified during normal pregnancy. The concentrations of AT III were significantly lower, a^ antitrypsin significantly higher and c^M no different when compared with those of the non pregnant and puerpiral states