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Pyrrolizidine Alkaloids from Lithospermum canescens Lehm. Helmut Wiedenfelda*, Agnieszka Pietrosiukb, Miroslava Furmanowab, and Erhard Roedera a Pharmazeutisches Institut der Universität, An der Immenburg 4, D-53121 Bonn. F. R. G. Fax: +49-2287360317. E-mail: wiedenfeld@uni-bonn.de b Department of Biology and Pharmaceutical Botany, Medical University of Warsaw, Banacha Str. 1, 02-097 Warsaw, Poland * Author for correspondence and reprint requests Z. Naturforsch. 58c, 173Ð176 (2003); received October 15/November 12, 2002 Seven pyrrolizidine alkaloids (PAs) have

). Assessment report on Symphytum offi cinale L., radix (EMA/HMPC/572844/2009), 2011 5. ***Scientifi c Opinion on Pyrrolizidine alkaloids in food and feed. EFSA Journal. 2011;9:2406-2540. 6. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie. 1995;50:83-98. 7. Mattocks AR. Spectrophotometric determination of unsaturated pyrrolizidine alkaloids. Anal. Chem. 1967;39:443-447. 8. Mattocks AR. Spectrophotometric determination of pyrrolizidine alkaloidssome improvements. Anal. Chem. 1968;40:1749-1750. 9. Barko Bartkowski JP, Wiedenfeld H, Roeder E

Pyrrolizidine Alkaloid Profiles of Some Senecio Species from Egypt Assem El-Shazly Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Egypt Z. Naturforsch. 57c, 429Ð433 (2002); received January 4/February 1, 2002 Pyrrolizidine Alkaloids, Senecio aegyptius, Senecionine Alkaloid profiles of two Egyptian Senecio species (Senecio aegyptius var. discoideus and S. desfontainei) in addition to a cultivated species (S. cineraria) were studied using capillary GLC and GLC-mass spectrometry with respect to pyrrolizidine alkaloids (PAs). Four alka- loids

Pyrrolizidine Alkaloid Profiles of the Senecio cineraria Group (Asteraceae) Rosa Tundisa,*, Monica R. Loizzoa, Giancarlo A. Stattia, Nicodemo G. Passalacquab, Lorenzo Peruzzib, and Francesco Menichinia a Department of Pharmaceutical Sciences, University of Calabria, I-87036 Arcavacata di Rende, CS, Italy. Fax: +39984493298. E-mail: rosa.tundis@unical.it b Natural History Museum of Calabria and Botanic Garden, University of Calabria, I-87036 Arcavacata di Rende, CS, Italy * Author for correspondence and reprint requests Z. Naturforsch. 62c, 467Ð472 (2007

References Allen JR, Hsu IC, Carstens LA. (1975). Dehydroretronecine-induced rhabdomyosarcomas in rats. Cancer Res 35: 997-1002. Bildfell R. (2013). Overview of Pyrrolizidine Alkaloidosis, Merck Veterinary Mannual. http://www.merckmanuals.com Bull LB, Culvenor CC, Dick AJ. (1968). The Pyrrolizidine Alkaloids. Their Chemistry, Pathogenicity and Other Biological Properties. Amsterdam: North- Holland. Chan PC, Haseman JK, Prejean J D, Nyska A. (2003). Toxicity and carcinogenicity of riddelliine in rats and mice. Toxicol Lett 144: 295- 311. Chauvin P, Dillon JC

Organ Specific Storage of Dietary Pyrrolizidine Alkaloids in the Arctiid Moth Creatonotos transiens A. Egelhaaf, K. Cölln, B. Schmitz, M. Buck Zoologisches Institut der Universität, Im Weyertal 119, D-5000 Köln 41, Bundesrepublik Deutschland M. Wink* Pharmazeutisches Institut der Universität, Saarstraße 21, D-6500 Mainz, Bundesrepublik Deutschland D. Schneider Max-Planck-Institut für Verhaltensphysiologie, D-8130 Seewiesen/Starnberg, Bundesrepublik Deutschland Z. Naturforsch. 45c, 115-120(1990); received September 25, 1989 Creatonotos, Arctiidae, Pyrrolizidine

Sequestration, N-Oxidation and Transformation of Plant Pyrrolizidine Alkaloids by the Arctiid Moth Tyria jacobaeae L. Adelheid Ehmke, Ludger Witte, Andreas Biller, and Thomas Hartmann Institut für Pharmazeutische Biologie der Technischen Universität Braunschweig, Mendelssohnstraße 1, D-3300 Braunschweig, Bundesrepublik Deutschland Z. Naturforsch. 45c, 1185 - 1192 (1990); received July 31/August 29, 1990 Tyria, Arctiidae, Pyrrolizidine Alkaloids, Callimorphine, N-Oxidation Larvae o f the arctiid moth Tyria jacobaeae reared on Senecio jacobaea or 5. vulgaris

Pyrrolizidine Alkaloids from Echium rauwolfii and Echium horridum (Boraginaceae) Assem El-Shazlyab, M. Abdel-Alla, Andreas Teib, and Michael Winkb a Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Egypt b Institut für Pharmazeutische Biologie der Universität Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany Z. Naturforsch. 54c, 295-300; received December 17, 1998/February 12, 1999 Echium rauwolfii, Echium horridum, Boraginaceae, Pyrrolizidine Alkaloids, Capillary GLC Echimidine was isolated from Echium rauwolfii and Echium

Isolation of the Pyrrolizidine Alkaloid Intermedine-N-oxide from Cerinthe glabra and ab initio Calculation of its 13C NMR Shifts Markus Lubera, Arafa Musaa,b, Hazem A. Kadryb, and Franz Brachera a Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstr. 5–13, 81377 Munich, Germany b Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt Reprint requests to Prof. Dr. Franz Bracher. Fax: +49-89-218077802. E-mail: Franz.Bracher@cup.uni-muenchen.de Z. Naturforsch. 2012, 67b, 411 – 416 / DOI

Introduction Pyrrolizidine alkaloids (PAs) are synthesised by plants as their secondary metabolites and are considered to be one of the most widespread toxins of natural origin ( 1 , 23 ). PAs have gained attention in the recent years due to their hepatotoxic, carcinogenic, genotoxic, and pneumotoxic properties ( 17 ). More than 6,000 plant species produce alkaloids and more than 660 PAs have been identified so far ( 5 , 15 ). PA-producing plants are introduced or are native species which are considered invasive and noxious weeds. They often infest open ranges