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DOI 10.1515/jpem-2012-0268       J Pediatr Endocr Met 2012; 25(11-12): 1217–1219 Short communication Betty S. van der Veen * , Maaike Appelhof and Tjalling W. de Vries Inhaled fluticasone propionate does not influence salivary cortisol when measured with tandem mass spectrometry Abstract: Long-term treatment with inhaled corticoster- oids (ICS) may potentially lead to adrenal insufficiency in children with asthma. A sufficient adrenal response can be tested using protocols involving salivary cortisol measurements. In this study, we investigated

References 1. Ducros V, Schmitt D, Pernod G, Faure H, Polack B, Favier A. Gas chromatographic-mass spectrometric determination of total homocysteine in human plasma by stable isotope dilution: method and clinical applications. J Chromatogr B Biomed Sci Appl 1999; 729:333–9. 2. Magera MJ, Lacey JM, Casetta B, Rinaldo P. Method for the determination of total homocysteine in plasma and urine by stable isotope dilution and electrospray tandem mass spectrometry. Clin Chem 1999; 45:1517–22. 3. Nelson BC, Pfeiffer CM, Sniegoski LT, Satterfield MB. Development and

Clin Chem Lab Med 2011;49(7):1213–1216 2011 by Walter de Gruyter • Berlin • Boston. DOI 10.1515/CCLM.2011.195 2010/661 Article in press - uncorrected proof Short Communication A simple liquid chromatography-tandem mass spectrometry method for measuring metanephrine and normetanephrine in urine Jessica Gabler, Abby Miller and Sihe Wang* Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA Abstract Background: Measuring urinary fractionated metanephrines is one of the initial tests in the diagnosis of pheochromocy- toma. Liquid chromatography-tandem

prevalence rate of a single disease is low, the overall incidence rate is about 1/2555 to 1/784 [ 1 ]. The clinical manifestations are not unique, and the diagnosis is difficult. Tandem mass spectrometry (TMS) is used in many screening programs to analyze amino acids and acylcarnitines in blood to detect disorders of amino acids, organic acids, and fatty-acid metabolism [ 2 ]. TMS newborn screening (NBS) has advanced to one comprehensive and complex screening system from simple blood [ 3 ], [ 4 ]. The technology has been introduced widely in the United States (50 states

Clin Chem Lab Med 2011;49(1):69–75 2011 by Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2011.005 2011/227 Article in press - uncorrected proof Determination of daptomycin in human plasma by liquid chromatography-tandem mass spectrometry. Clinical application Marie-Clémence Verdier1,2, Danièle Bentué- Ferrer1,2,*, Olivier Tribut1, Nicolas Collet1, Matthieu Revest3 and Eric Bellissant1,2 1 Biological Pharmacology and Toxicology, University Hospital, Rennes 1 University, Rennes, France 2 Inserm 0203 Clinical Investigation Center, University Hospital

, voriconazole, by multidimensional high-performance liquid chromatography with direct plasma injection onto a size-exclusion column. J Chromatogr B Biomed Sci Appl 1997; 691: 441–8. 12. Gage R, Stopher DA. A rapid HPLC assay for voriconazole in human plasma. J Pharm Biomed Anal 1998; 17: 1449–53. 13. Pennick GJ, Clark M, Sutton DA, Rinaldi MG. Development and validation of a high-performance liquid chromatography assay for voriconazole. Antimicrob Agents Chemother 2003; 47: 2348–50. 14. Dooley KC. Tandem mass spectrometry in the clinical chemistry laboratory. Clin Biochem

Rev Anal Chem 30 (2011): 5–9 © 2011 by Walter de Gruyter • Berlin • New York. DOI 10.1515/REVAC.2011.008 Analysis of clenbuterol residues in pig liver using liquid chromatography electrospray ionization tandem mass spectrometry Jelka Pleadin 1, *, Igor Brato š 2 , Ana Vuli ć 1 , Nina Per š i 1 and Jelena Ð ugum 3 1 Laboratory for Analytical Chemistry , Croatian Veterinary Institute, Savska 143, 10 000 Zagreb , Croatia , e-mail: 2 Pliva Research Institute , Prilaz Baruna Filipovi ć a 29, 10 000 Zagreb , Croatia

measurement) – gives the possibility to distinguish endogeneous hormones ( e.g . testosterone, boldenone, nortestosterone (nandrolone), and oestradiol) from their synthetic analogues that may have been administered to animals, and can do this in confirmatory urine tests ( 23 ). However, due to the high operating costs, GC–C-IRMS measuring instruments are only available in very few EU laboratories, and they are those performing national official residue surveillance tests. Steroid esters are non-volatile, therefore liquid chromatography with tandem mass spectrometry (LC

Clin Chem Lab Med 2010;48(12):1723–1731 2010 by Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2010.333 2010/222 Article in press - uncorrected proof Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry Ralf Krüger1,*, Michael Vogeser2, Stephan Burghardt3, Rita Vogelsberger1 and Karl J. Lackner1 1 Institute of Clinical Chemistry and Laboratory Medicine, Medical Center of the Johannes Gutenberg University, Mainz, Germany 2 Institute of Clinical Chemistry, Hospital of the University of Munich

References 1 Vogeser M, Fleischer C, Meiser B, Groetzner J, Spöhrer U, Seidel D. Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extraction. Clin Chem Lab Med 2002; 40: 40–5. 2 Volosov A, Napoli KL, Soldin SJ. Simultaneous simple and fast quantification of three major immunosuppressants by liquid chromatography-tandem mass-spectrometry. Clin Biochem 2001; 34: 285–90. 3 Keevil BG, Tierney DP, Cooper DP, Morris MR. Rapid liquid chromatography-tandem mass spectrometry method for routine analysis of