. [Regulation of human hair growth by cosmetics - facts and myths]. Dermatol Estet 2007; 6(53):367-377. 5. Blume-Peytavi U, Blumeyer A, Tosti A Finner A, Marmol V, Trakatelli M. S1 guideline for diagnostic evaluation in androgeneticalopecia in men, women and adolescents. Br J Dermatol 2010; 164:5-15. 6. Aburjai T, Natsheh F. Plants used in cosmetics. Phytother Res 2003; 17(9):987-1000. 7. Messenger A. Male AndrogeneticAlopecia. In: Blume-Peytavi U, Tosti A, Whiting DA, Trűeb RM (eds). Hair Growth and Disorders. Berlin, Springer-Verlag, 2008:166-168. 8. Park WS, Lee CH, Lee
Horm Mol Biol Clin Invest 2010;1(2):95–102 2009 by Walter de Gruyter • Berlin • New York. DOI 10.1515/HMBCI.2010.010
Article in press - uncorrected proof
The influence of low dose finasteride, a type II 5a-reductase
inhibitor, on circulating neuroactive steroids
Michaela Dušková*, Martin Hill and
Institute of Endocrinology, CZ 11694 Prague 1,
Background: Finasteride is a 5a-reductase inhibitor that has
received clinical approval for the treatment of human benign
prostatic hyperplasia and androgeneticalopecia
Introduction. Capillaroscopy is a non-invasive imaging method that allows cutaneous microcirculation to be analyzed. During the last decades, a diagnostic and prognostic potential of nailfold capillaroscopy (NVC) has been gaining increasing appreciation. The main indications include Raynaud phenomenon and scleroderma spectrum diseases, however the usefulness of this technique is also suggested in a variety of non-rheumatic diseases.
Aim. To assess capillaroscopic patterns in systemic scleroderma (SSc), psoriasis (PV), psoriatic arthritis (PsA), alopecia areata (AA) and androgenetic alopecia. To evaluate serum levels of several endothelial and angiogenic markers, and their relation to capillaroscopic pattern.
Material and methods. There were evaluated 295 patients with systemic scleroderma (SSc), psoriasis (PV), psoriatic arthritis (PsA), alopecia areata (AA) and androgenetic alopecia, as well as age- and sex-matched controls, were examined. In each subject, NVC was performed and serum concentration levels of several angiogenic markers.
Results. In SSc three NVC patterns: early, active and late were distinguished. Angiopoietin-2 concentrations were higher and andothelial microparticles were lower in patients with late NVC pattern. We found several differences between the NVC pattern in PV and PsA. No correlations between NVC pattern and serum levels of angiogenic markers were revealed. In AA, we distinguished both normal and abnormal NVC patterns, although the normal patterns were more frequent. Branching capillaries and features of neoformation were often present in patients with the abnormal pattern. In androgenetic alopecia, the normal NVC pattern was most frequently present, however, we found several statistically significant capillarosopic alterations, like branching capillaries, features of neoformation and altered distribution of capillaries.
Discussion and Conclusions. Serum levels of Ang-2 and EMPs may reflect capillary damage in SSc. NVC pattern varies between PV and PsA patients. The presence of abnormal NVC patterns in alopecia patients might show the role of disturbances in microcirculation in the diseases. Further studies are required to confirm the hypothesis.
the treatment of androgeneticalopecia: a randomized comparative trial, Skinmed. 13 (2015) 15–21. 10. M. Y. Dhariwala and P. Ravikumar, An overview of herbal alternatives in androgeneticalopecia, J. Cosmet. Dermatol. (2019); https://doi.org/10.1111/jocd.12930 11. B. Y. Choi, Hair-growth potential of ginseng and its major metabolites: A review on its molecular mechanisms, Int. J. Mol. Sci. 19 (2018) E2703; https://doi.org/10.3390/ijms19092703 12. H. J. Ryu, M. G. Yoo and S. W. Son, The efficacy of 3% minoxidil vs. combined 3% minoxidil and Korean red ginseng
scher Einnahme immer wieder in der Einnahmepause anlaufende An-
drogensynthese im Ovar reduziert oder ganz vermieden.
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Introduction 5α-Reductase inhibitors (5α-RIs) finasteride and dutasteride and α-adrenergic receptor blockers (ARB), such as tamsulosin, are widely used treatments of lower urinary tract symptoms (LUTS), secondary to benign prostatic hyperplasia (BPH) [ 1 ], [ 2 ]. 5α-RIs therapy with finasteride is also widely used for treatment of male pattern hair loss (MPHL) commonly known as androgeneticalopecia (AGA) [ 3 ], [ 4 ]. However, among the main concerns of 5α-reductase inhibitors therapy is the potential serious adverse sexual side effects [ 1 ], [ 5 ], [ 6 ], [ 7
Introduction 5α-Reductase inhibitors (5α-RIs) therapy with finasteride or dutasteride and α1-adrenergic receptor blockers such as tamsulosin are widely used for treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) [1, 2]. 5α-RIs therapy with finasteride is also widely used for treatment of male pattern hair loss (MPHL), commonly known as androgeneticalopecia (AGA) [3, 4]. However, one of the main concerns with 5α-RIs therapy is the serious adverse effects on sexual function [1, 5–16]. Considerable controversy exists