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structure demonstrated enhanced leaflet opening and closing as a result of stent deformation and redirected loading. Crimping and subsequent release into the AR model as well as the stent adaption to the target region after expansion proved the suitability of the TAV design for percutaneous application. FEA represented a useful tool for numerical simulation of an entire minimally invasive heart valve prosthesis in relevant clinical scenarios. Keywords: Finite-element analysis, transcatheter aortic valve prosthesis, aortic root model.

printing and silicone cast molding for manufacturing of aortic root models with variable degree of stenosis. Design of aortic roots with normal, mild and severe stenosis was developed according to Reul et al. For manufacturing of tripartite cast- ing molds, a 3D printer was used. Both outer mold parts and the mold core were manufactured from polylactide filament and water soluble polyvinylalcohol filament, respectively. In vitro hydrodynamic performance testing of an exemplary commercially available TAVP implanted in different aortic root models was conducted

Commons Attribution- NonCommercial-NoDerivatives 4.0 License. Current Directions in Biomedical Engineering 2018; 4(1): 259 – 262 2 Materials and methods 2.1 Design parameter The geometric model used in this study consists of a generic aortic root model with three identical leaflets that are based on previously published literature [4-5]. The aortic root was created using computer-aided design (CAD) software Creo Parametric 3.0 (Parametric Technology Corp., Needham, MA, USA). The shape of the aortic root was defined by five geometric parameters